胡晓丽

发布者:杨光发布时间:2020-01-10浏览次数:3740




胡晓丽博士,教授,博士生导师

联系方式

电子邮箱:HXL707@ouc.edu.cn

工作电话:0532-82031970

联系地址:青岛市鱼山路5号中国海洋大学化学馆224


学习工作经历

1989.91993.7 青岛海洋大学水产学院食品工程专业学士

2000.92005.6 中国海洋大学海洋生命学院海洋生物学专业博士

1993.92000.8青岛市农业科学研究所科研管理

2005.7-至今中国海洋大学海洋生命学院教师

2009.82010.8 美国斯坦福大学生物系访问学者

研究方向

主要从事贝类遗传学与育种研究。运用遗传学、分子生物学、细胞生物学、生物化学等技术手段,揭示贝类经济性状形成的遗传基础和调控机理,发掘性状关键基因和调控元件,研发贝类育种技术,培育优质高产扇贝良种。

主要科研项目

在研项目

1. 国家重点研发计划蓝色粮仓科技创新重点专项:水产养殖生物生长和品质性状的遗传基础与调控机理研究,2018-2022,项目主持

2. 国家自然科学基金主任基金:我国水产种业2035发展战略研究,2019-2020,第2

3. 国家自然科学基金重点项目:虾夷扇贝积累与代谢类胡萝卜素的遗传基础解析与调控机理研究,2017-2021,第2

4. 山东省自然科学基金:海洋贝类模式动物平台创建,2018-2020,第3

完成项目

1. 国家重点基础研究发展规划项目计划(973计划):贝类分子设计育种的关键技术研究2010-2014,课题主持

2. 国家自然科学基金面上项目:虾夷扇贝Prop1基因功能及表达调控研究,2015-2018,项目主持

3. 国家自然科学基金面上项目:引种日本皱纹盘鲍对我国本土种质资源遗传结构影响的研究,2012-2015,项目主持

4. 国家自然科学基金面上项目:栉孔扇贝抑肌素myostatin及其信号途径基因的表达调控,2010-2012,项目主持

5. 国家高技术研究发展计划(863计划)重大项目课题:海洋生物分子细胞育种关键技术,2012-2015,子课题主持

6. 国家科技支撑计划项目课题:黄渤海区典型海湾复合养殖技术集成与示范,2011-2015,子课题主持

7. 国家重点基础研究发展规划项目计划(973计划):贝类SNP规模发掘及高密度遗传连锁图谱的构建,2010-2014,子课题主持

8. 国家高技术研究发展计划(863计划)重大项目课题:重要生产性状关键基因的发掘与应用技术,2006-2010,子课题主持

  

近五年主要论文*通讯作者,#共同第一作者)

lXiaogang Xun#, Jie Cheng#, Jing Wang, Yangping Li, Xu Li, Moli Li, Jiarun Lou, Yifan Kong, Zhenmin Bao, Xiaoli Hu*. Solute carriers in scallop genome: Gene expansion and expression regulation after exposure to toxic dinoflagellate. Chemosphere. 2020. 241:124968.

lXue Li#, Shuyue Wang#, Xiaogang Xun, Mengran Zhang, Shi Wang, Hengde Li, Liang Zhao, Qiang Fu, Huizhen Wang, Tingting Li, Shanshan Lian, Qiang Xing, Xu Li, Wei Wu, Lingling Zhang, Xiaoli Hu*, Zhenmin Bao*. A carotenoid oxygenase is responsible for muscle coloration in scallop. Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids. 2019. 1864:966-975.

lBoyang Hu, Moli Li, Xiaohan Yu, Xiaogang Xun, Wei Lu, Xu Li , Yajuan Li , Jiarun Lou , Shi Wang, Lingling Zhang, Jie Cheng*, Xiaoli Hu*, Zhenmin Bao. Diverse expression regulation of Hsp70 genes in scallops after exposure to toxic Alexandrium dinoflagellates. Chemosphere. 2019. 234:62-69.

lXianhui Ning, Xue Li, Jing Wang, Xiangchao Zhang, Lingling Kong, Deting Meng, Huizhen Wang, Yajuan Li, Lingling Zhang, Shi Wang, Xiaoli Hu*, Zhenmin Bao. Genome-wide association study reveals E2F3 as the candidate gene for scallop growth. Aquaculture. 2019. 511:734216.

lShanshan Lian#, Liang Zhao#, Xiaogang Xun, Jiarun Lou, Moli Li, Xu Li, Shi Wang, Lingling Zhang, Xiaoli Hu*, Zhenmin Bao. Genome-wide identification and characterization of SODs in Zhikong scallop reveals gene expansion and regulation divergence after Toxic dinoflagellate exposure. Marine Drugs. 2019. 17: 700.

lShuyue Wang, Xu Li, Tingting Li, Huizhen Wang, Xiangchao Zhang, Jiarun Lou, Qiang Xing, Xiaoli Hu*, Zhenmin Bao. The GRP94 gene of Yesso scallop (Patinopecten yessoensis): Characterization and expression regulation in response to thermal and bacterial stresses.Fish & Shellfish Immunology. 2018.80:443-451.

lXianhui Ning, Liying Feng, Xue Li, Shuyue Wang, Mengran Zhang, Shi Wang, Lingling Zhang, Xiaoli Hu*, Zhenmin Bao. The scallop IGF2 mRNA-binding protein gene PyIMP and association of a synonymous mutation with growth traits. Genes & Genetic Systems. 2018. 1-13.

lYuli Li#, Xiaoqing Sun#, Xiaoli Hu#, Xiaogang Xun, Jinbo Zhang, Ximing Guo, Wenqian Jiao, Lingling Zhang, Weizhi Liu, Jing Wang, Ji Li, Yan Sun, Yan Miao, Xiaokang Zhang, Taoran Cheng, Guoliang Xu, Xiaoteng Fu, Yangfan Wang, Xinran Yu, Xiaoting Huang, Wei Lu, Jia Lv, Chuang Mu, Dawei Wang, Xu Li, Yu Xia, Yajuan Li, Zhihui Yang, Fengliang Wang, Lu Zhang, Qiang Xing, Huaiqian Dou, Xianhui Ning, Jinzhuang Dou, Yangping Li, Dexu Kong, Yaran Liu, Zhi Jiang, Ruiqiang Li*, Shi Wang*, Zhenmin Bao*. Scallop genome reveals molecular adaptations to semi-sessile life and neurotoxins. Nature Communications. 2017. 8:1721.

lShi Wang, Jinbo Zhang, Wenqian Jiao, Ji Li, Xiaogang Xun, Yan Sun, Ximing Guo, Pin Huan, Bo Dong, Lingling Zhang, Xiaoli Hu, Xiaoqing Sun, Jing Wang, Chengtian Zhao, Yangfan Wang, Dawei Wang, Xiaoting Huang, Ruijia Wang, Jia Lv, Yuli Li, Zhifeng Zhang, Baozhong Liu, Wei Lu, Yuanyuan Hui, Jun Liang, Zunchun Zhou, Rui Hou, Xue Li, Yunchao Liu, Hengde Li, Xianhui Ning, Yu Lin, Liang Zhao, Qiang Xing, Jinzhuang Dou, Yangping Li, Junxia Mao, Haobing Guo, Huaiqian Dou, Tianqi Li, Chuang Mu, Wenkai Jiang, Qiang Fu, Xiaoteng Fu, Yan Miao, Jian Liu, Qian Yu, Ruojiao Li, Huan Liao, Xuan Li, Yifan Kong, Zhi Jiang, Daniel Chourrout*, Ruiqiang Li* and Zhenmin Bao*. Scallop genome provides insights into evolution of bilaterian karyotype and development. Nature Ecology & Evolution. 2017. 1: 0120.

lJie Cheng, Xiaogang Xun, Yifan Kong, Shuyue Wang, Zhihui Yang, Yajuan Li, Dexu Kong, Shi Wang, Lingling Zhang, Xiaoli Hu*, Zhenmin Bao. Hsp70 gene expansions in the scallop Patinopecten yessoensis and their expression regulation after exposure to the toxic dinoflagellate Alexandrium catenella. Fish & Shellfish Immunology. 2016. 58:266-273.

lJie Cheng, Jing Wang, Shuyue Wang, Ruojiao Li, Xianhui Ning, Qiang Xing, Xiaoli Ma, Lingling Zhang, Shi Wang, Xiaoli Hu*, Zhenmin Bao. Characterization of TRAF3IP1 gene in Yesso scallop (Patinopecten yessoensis) and its expression responses to bacterial challenge. Genes & Genetic Systems. 2016. 91(5):267-276.

lQiang Fu, Huihui Guo, Liying Feng, Xue Li, Lingling Zhang, Shi Wang, Xiaoli Hu*, Zhenmin Bao*. Association of myostatin variants with growth traits of Zhikong scallop (Chlamys farreri). Journal of Ocean University of China. 2016. 15(1): 145-151.

lXue Li, Xianhui Ning, Jinzhuang Dou, Qian Yu, Shuyue Wang, Lingling Zhang, Shi Wang, Xiaoli Hu*, Zhenmin Bao. An SCD gene from the Mollusca and its upregulation in carotenoid-enriched scallops. Gene. 2015. 564: 101-108.

lJiajun Zou, Ruijia Wang*, Rujiao Li, Yifan Kong, Jing Wang, Xianhui Ning, Lingling Zhang, Shi Wang, Xiaoli Hu*, Zhenmin Bao.The genome-wide identification of mitogen-activated protein kinase kinase (MKK) genes in Yesso scallop Patinopecten yessoensis and their expression responses to bacteria challenges. Fish & Shellfish Immunology. 2015. 45(2): 901-911.

lXianhui Ning, Ruijia Wang*, Xue Li, Shuyue Wang, Mengran Zhang, Qiang Xing, Yan Sun, Shi Wang, Lingling Zhang, Xiaoli Hu*, Zhenmin Bao. Genome-wide identification and characterization of five MyD88 duplication genes in Yesso scallop (Patinopecten yessoensis) and expression changes in response to bacterial challenge. Fish & Shellfish Immunology. 2015. 46(2):181-191.

lQian Yu, Yangping Li, Qiang Xing, Xue Li, Liang Zhao, Yangfan Wang, Xiaoli Hu*, Zhenmin Bao. Forty-nine SNP markers developed from the genome dataset of Pacific abalone (Haliotis discus hannai) and their application in population genetic analysis. Conservation Genetics Resources. 2015. 7(4):781-787.

lXue Li, Ruijia Wang*, Xiaogang Xun, Wenqian Jiao, Mengran Zhang, Shuyue Wang, Shi Wang, Lingling Zhang, Xiaoting Huang, Xiaoli Hu*, Zhenmin Bao. The Rho GTPase Family Genes in Bivalvia Genomes: Sequence, Evolution and Expression Analysis. PLoS ONE. 2015.10(12): e0143932.

lQian Yu, Yangping Li, Qiang Xing, Linhua Hao, Xue Li, Meiwei Zhang, Yangfan Wang, Xiaoli Hu*, Zhenmin Bao. Identification of SNPs with different allele frequencies in China and Japan population of Pacific abalone (Haliotis discus hannai). Conservation Genetics Resources. 2015. 7:837-840.

  

主要专利

l胡晓丽,包振民,郭慧慧,宁先会,李雪,于茜,王师,张玲玲,陆维. 一种栉孔扇贝生长性状相关的SNP位点及其应用ZL201510638440.4

l胡晓丽,包振民,于茜,李仰平,王师,张玲玲,陆维. 一种皱纹盘鲍中国和日本群体鉴别用SNP标记(ZL201510719444.5

l胡晓丽,包振民,黄晓婷,王师,张玲玲,陆维,王扬帆. 一种饵料藻自动培养与投加装置(ZL 201310278454.0

l包振民,胡晓丽,封利颖,于茜,李雪,张玲玲,王师,邹佳君. 一种虾夷扇贝生长性状相关的SNP位点及其检测和应用(ZL201410035028.9

l包振民,胡晓丽,张玲玲,王师,郭慧慧,张月月. 栉孔扇贝TGF-ß I型受体基因及其SNP位点(ZL201210439861.0

l包振民,胡晓丽,张玲玲,王师,黄晓婷,王扬帆,陆维.一种饵料藻自动培养与投加方法(申请号:ZL201310277425.2

  

荣誉奖励

l教育部新世纪人才(2009

l山东省泰山产业领军人才(2018

l国家技术发明二等奖(第3位,2018

l国家科技进步二等奖(第6位,2008

l教育部技术发明一等奖(第3位,2016

l山东省技术发明一等奖(第3位,2016

l教育部科技进步一等奖(第3位,2007

l青岛市科技进步一等奖(第3位,2007