付慧慧，博士，副教授，博士生导师
电话：0532-85905739
学习工作经历:
2007-2011，烟台大学，生物科学，学士
2011-2016，浙江大学，微生物学，博士
2016-2018，中国科学院海洋研究所实验海洋生物学重点实验室，博士后（助理研究员）
2019-2025，中国海洋大学海洋生命学院，“青年英才工程”第三层次副教授
2025至今，中国海洋大学海洋生命学院，副教授
主要科研领域：
利用生理遗传学、分子生物学、生物化学等技术开展海洋微生物驱动碳、氮、硫等元素循环的过程和机制研究，阐明海洋微生物代谢重要有机物的过程及调控机制。代表性成果以第一/通讯作者在The EMBO Journal、mBio、Applied and Environmental Microbiology等领域权威刊物期刊上。主持国家自然科学基金面上项目1项、国家重点研发计划子课题1项、山东省自然科学基金面上项目1项。获国家首批“博士后创新人才支持计划”支持。
代表性研究成果：(#共同第一；*通讯作者)
1. Hui-Hui Fu#; Ming-Chen Wang#; Zhi-Qing Wang; Yu-Han Sang; Zhen-Kun Li; Fei-Fei Li; Jia-Rong Liu; Qi-Long Qin; Xiao-Yu Zhu; Na Wang; Jin-Jian Wan; Zhao-Jie Teng; Wei-Peng Zhang; Andrew J Gates; Chun-Yang Li; Jonathan D Todd*; Yu-Zhong Zhang*. Regulation of DMSP organosulfur cycling in ubiquitous Roseobacter marine bacteria, The EMBO Journal, 2026, 45(6): 1980-1996.
2. Na Wang; Yu-Han Sang; Zhen-Kun Li; Ming-Chen Wang; Jia-Rong Liu; Fan Wang; Yu-Zhong Zhang; Hui-Hui Fu*. Coordinated regulation of trimethylamine catabolism in abundant marine bacteria. Applied and Environmental Microbiology, 2026, 92(7): e0105826.
3. Jia-Rong Liu; Zhen-Kun Li; Ming-Chen Wang; Na Wang; Zhi-Qing Wang; Fei-Fei Li; Yin Chen; Yu-Zhong Zhang; Hui-Hui Fu*. Novel regulatory mechanism of choline-O-sulfate and choline catabolism by two BetIs in Alphaproteobacteria, Applied and Environmental Microbiology, 2025, 91(9): e0033325.
4. Chao Gao; Hai-Tao Ding; Kang Li; Hai-Yan Cao; Ning Wang; Zeng-Tian Gu; Qing Wang; Mei-Ling Sun; Xiu-Lan Chen; Yin Chen; Yu-Zhong Zhang; Hui-Hui Fu*; Chun-Yang Li*. Structural basis of a microbial trimethylamine transporter, mBio, 2025, 16(1): e0191424.
5. Jia-Rong Liu#; Zhi-Qing Wang#; Fei-Fei Li; Zhen-Kun Li; Ming-Chen Wang; Na Wang; Yu An; Xiu-Lan Chen; Yu-Zhong Zhang; Hui-Hui Fu*. Crp and Arc system directly regulate the transcription of NADH dehydrogenase genes in Shewanella oneidensis nitrate and nitrite respiration, Microbiology Spectrum, 2025, 13(7): e0332424.
6. Yan Wang; Zhen Wang; Wen-Xiao Zhao; Xiao-Jie Yuan; Yang Yu; Peng Wang; Min Wang; *************; Yu-Zhong Zhang; Ming Peng*; Hui-Hui Fu*; Xiu-Lan Chen*. Trans-4-hydroxy-L-proline catabolism by Pseudomonadota in the ocean, Marine Life Science & Technology, 2025, 7(1): 187-202.
7. Na Wang#; Jia-Rong Liu#; Xi-Ying Zhang; Shen Fan; Yu-Zhong Zhang; Hui-Hui Fu*. Mesonia profundi sp. nov., isolated from deep-sea sediment of the Mariana Trench. International Journal of Systematic and Evolutionary Microbiology, 2024. 74:006211.
8. Yu An; Ming-Chen Wang, Xiao-Yan Su, Shen-Fan, Jie Lu, Jin-Jian Wan, Yu Xin, Yu-Zhong Zhang, Xi-Ying Zhang*, Hui-Hui Fu*. Salinimicrobium profundisediminis sp. nov., isolated from deep-sea sediment of the Mariana Trench. International Journal of Systematic and Evolutionary Microbiology, 2023. 73:005877.
9. Fan Wang#; Jin-Jian Wan#; Xi-Ying Zhang; Yu Xin; Mei-Ling Sun; Peng Wang; Wei-Peng Zhang; Ji-Wei Tian; Yu-Zhong Zhang; Chun-Yang Li*; Hui-Hui Fu*.Halomonas profundi sp. nov., isolated from deep-sea sediment of the Mariana Trench. International Journal of Systematic and Evolutionary Microbiology, 2022. 72(1):005210.
10. Hui-Hui Fu; Lu-Lu Liu; Zi-Yang Dong; Shu-Pan Guo; Hai-Chun Gao*. Dissociation between iron and heme biosynthesis is largely accountable for respiration defects of Shewanella oneidensis fur mutants. Applied and Environmental Microbiology, 2018. 84:e00039-18.
11. Hui-Hui Fu; Miao Jin; Fen Wan; Hai-Chun Gao*. Shewanella oneidensis cytochrome c maturation component CcmI is essential for heme attachment at the non-canonical motif of nitrite reductase NrfA. Molecular Microbiology, 2015. 95(3):410-425.
12. Hui-Hui Fu#; Miao Jin#; Li-Li Ju; Yin-Ting Mao; Hai-Chun Gao*. Evidence for function overlapping of CymA and the cytochrome bc1 complex in the Shewanella oneidensis nitrate and nitrite respiration. Environmetnal Microbiology, 2014. 16(10):3181-3195.
13. Hui-Hui Fu; Hai-Jiang Chen; Ji-Xuan Wang; Guang-Qi Zhou; Hai-Yan Zhang; Li-Li Zhang; Hai-Chun Gao*. Crp-dependent cytochrome bd oxidase confers nitrite resistance to Shewanella oneidensis. Environmental Microbiology, 2013. 15(8):2198-2212.
