张晓华

发布者:杨光发布时间:2018-09-19浏览次数:707

张晓华博士、教授/博士生导师

 

个人简历

姓名:张晓华

学历/职称/职务:博士/教授/博士生导师

联系方式:

邮箱:xhzhang@ouc.edu.cn              电话:0532-82032767 (办公室)

地址:青岛市鱼山路5号 青岛266003 中国海洋大学海洋生命学院

工作照:

 

学习工作简历:

1983.091987.07山东大学生物系动物学专业,获学士学位

1987.091990.07山东大学生物系动物生理专业,获硕士学位

1990.081994.10山东省海洋药物研究所,助理研究员

1994.101998.04青岛海洋大学海洋生命学院讲师、副教授(1997.12)

1998.042000.11英国赫里奥特-瓦特大学生物系微生物学专业,获博士学位

2000.122003.11英国牛津大学动物学系博士后

2003.112004.06英国剑桥大学遗传系博士后

2004.07至今:中国海洋大学海洋生命学院副教授、教授(2004.12)、博士生导师(2005.12)

科研领域描述:

主要研究方向为海洋微生物学,主要包括海洋微生物的生物地球化学作用、海洋细菌的密度感应及密度感应淬灭、海洋微生物的分离鉴定及资源开发等。

1.       海洋微生物的生物地球化学作用:包括海洋微生物在在海洋环境中的时空分布、环境响应以及在海洋碳循环、氮循环、硫循环中的作用等;

2.       海洋细菌的密度感应及密度感应淬灭:包括细菌密度感应对海洋颗粒有机碳降解的调控作用等;

3.海洋微生物多样性及资源开发:包括海洋微生物分离培养新技术的建立、海洋新菌的分类鉴定、海洋微生物菌种库的建立以及酶资源及有益菌的开发等。

主要研究课题:

2004.012006.12主持国家自然科学基金项目海洋弧菌中溶血素的研究30371119),经费20万元。

2005.012007.12入选2004年教育部新世纪优秀人才支持计划(NCET-04-0645),经费50万元。

2007.122010.12主持国家863计划项目中国黄海微生物资源采集、保存和信息化技术2007AA09Z434),经费100万元。

2008.012010.12主持国家自然科学基金项目哈维氏弧菌VHH溶血素作用机理的研究30771656),经费32万元。

2008.012009.12主持教育部科学技术研究重点项目致病性哈维氏弧菌毒性相关质粒的研究108082),经费10万元。

2009.012011.12主持国家自然科学基金项目海洋拮抗菌假交替单胞菌JG1作用机理的研究40876067),经费44万元。

2009.012011.12主持国家自然科学基金委与香港研究资助局(NSFC-RGC)联合科研基金项目弧菌毒力因子对鱼类细胞保护和细胞调亡的作用研究”   (30831160512),内地经费31.5万元。

2008.122012.12国家 863计划重点项目迟钝爱德华氏菌毒力相关功能基因研究及疫苗开发2008AA092501),参与,个人经费84万元。

2012.012015.12国家 863计划重点项目深海微生物分离培养与基因资源获取技术研究2012AA092103)子课题深海微生物高通量分离培养技术及装置研发,主持,经费190万元。

2012.072014.06主持科技部国际科技合作重点项目利用密度感应抑制技术控制水产养殖细菌性病害的合作研究2012DFG31990),经费100万元。

2013.012016.12主持国家自然科学基金项目南太平洋环流区洋底沉积物及海水的微生物群落演化及功能活性研究41276141),经费87万元。

2013.012018.12国家自然科学基金创新群体项目“海洋有机生物地球化学”(41221004 &延续41521064),参加,个人经费34万元。

2013.012015.09中国大洋协会国际海域资源调查与开发“十二五”项目“深海结核、结壳区微生物多样性与资源潜力评价”(DY125-15-R-03),参加,个人经费104万元。

2015.012018.12主持国家自然科学基金项目我国边缘海颗粒有机碳中细菌密度感应及其对有机碳降解的调控作用41476112),经费100万元。

2016.062021.05国家重点研发计划“全球变化及应对”重点专项“中国东部陆架海域生源活性气体的生物地球化学过程及气候效应”项目课题3“微生物在海洋生源活性气体循环中的作用与机制”(2016YFA0601303)。个人经费120万。

2018.012022.12主持国家自然科学基金重点项目“弧菌在我国边缘海的生态分布及在碳循环中的作用研究”(41730530)。经费376.4万元(直接经费315万元)。

2018.012021.12主持国家自然科学基金委“水圈微生物驱动地球元素循环的机制”重大研究计划重点支持项目“海洋异养细菌对DMSP/DMS产生的贡献及驱动硫循环的机制:以马里亚纳海沟为例”(91751202)。经费382.3万元(直接经费320万元)。

获奖情况及荣誉称号:

1. 入选2004年教育部新世纪优秀人才支持计划

2. 2010年国家海洋局海洋创新成果二等奖(第1位),获奖题目:哈维氏弧菌溶血素的发现与致病机理。

3. 2014年国家海洋局海洋科学技术二等奖(第1位),获奖题目:海洋微生物培养新技术的建立及菌种库建设。

4. 2014年青岛市自然科学二等奖(第1位),获奖题目:海水鱼类主要病原菌的致病性及其环境适应机制。

5.获201420162017年山东省优秀硕士学位论文指导教师。

代表性论文

1.         Lin H, Yu M, Wang X, and Zhang   X-H*. Comparative genomic analysis reveals the evolution and   environmental adaptation strategies of vibrios. BMC Genomics, 2018, 19:135.   (SCI, IF2017:3.730)

2.         Wang L, Yu M, Liu Y, Liu J, Wu Y, Li L, Liu J, Wang M and Zhang X-H*.  Comparative analyses of the bacterial   community of hydrothermal deposits and seafloor sediments across Okinawa   Trough. J Mar Sys, 2018, 180: 162-172. (SCI, IF2017: 2.506)

3.         Curson A, Liu J, Martinez AB, Green R, Chan Y, Carrion O, Williams B,   Zhang S-H, Yang G-P, Page PB, Zhang   X-H* & Todd J*. 2017. Dimethylsulphoniopropionate biosynthesis in   marine bacteria and identification of the key gene in this process. Nat Microbiol, 2017, 2: e17009. (SCI,   IF2017: 14.174)

4.         Gao M, Liu J, Qiao Y, Zhao M, Zhang   X-H*. 2017. Diversity and abundance of the denitrifying-microbiota in the   sediment of eastern China marginal seas and the impact of environmental   factors. Microb Ecol, 73, 602–615. (SCI, IF2015: 3.232)

5.         Yu S, Yao P, Liu J, Zhao B, Zhang G, Zhao M, Yu Z and Zhang X-H*. 2016. Diversity,   abundance, and niche differentiation of ammonia-oxidizing prokaryotes in mud   deposits of the eastern China marginal seas. Front Microbiol, 7:137. (SCI,   IF2015: 4.165;被引用1)

6.         Wang Y, Song Q, Zhang X-H*.   Marine microbiological enzymes: studies with multiple strategies and   prospects. Mar Drugs, 14(10), 171. (SCI, IF2015: 3.345)

7.         D'Hondt S, Inagaki F, Zarikian C, Abrams L, Dubois N, Engelhardt T,   Evans H, Ferdelman T, Gribsholt B, Harris R, Hoppie B, Hyun J-H, Kallmeyer J,   Kim J, Lynch J, McKinley C, Mitsunobu S, Morono Y, Murray R, Pockalny R,   Sauvage J, Shimono T, Shiraishi F, Smith D, Smith-Duque C, Spivack A,   Steinsbu B, Suzuki Y, Szpak M, Toffin L, Uramoto G, Yamaguchi Y, Zhang G-L, Zhang X-H, and Ziebis W. 2015.   Presence of oxygen and aerobic communities from seafloor to basement in   deep-sea sediment. Nature Geoscience, 8(4), 299-304. (SCI, IF2015: 12.508)

8.         Tang K, Su Y, Brackman G, Cui F, Zhang Y, Shi X, Coenye T, Zhang X-H*. 2015. MomL, a novel   marine-derived N-acyl homoserine lactonase from Muricauda olearia. Appl   Environ Microbiol, 81:774 –782. (SCI, IF2015: 3.823)

9.         Zhang Y, Liu J, Tang K, Yu M, Coenye T, Zhang X-H*. 2015. Genome analysis of Flaviramulus ichthyoenteri   Th78T in the family Flavobacteriaceae: insights into its quorum quenching   property and potential roles in fish intestine. BMC Genomics, 16:38. (SCI,   IF2015: 3.867)

10.     Liu J, Fu B, Yang H, Zhao M, He B, Zhang X-H*. 2015. Phylogenetic shifts of bacterioplankton   community composition along the Pearl Estuary: the potential impact of   hypoxia and nutrients. Front Microbiol, 6, 64. (SCI, IF2015: 4.165)

11.     Fu B, Liu J, Yang H, Hsu TC, He B, Dai M, Kao SJ, Zhao M, Zhang X-H*. 2015. Shift of anammox   bacterial community structure along the Pearl Estuary and the impact of   environmental factors. J Geophys Res – Oceans, 120, 2869–2883. (SCI, IF2015:   3.318)

12.     Liu J, Liu X, Wang M, Qiao Y, Zheng Y, Zhang X-H*. 2015. Bacterial and archaeal communities in sediments   of the north Chinese marginal seas. Microb Ecol, 70, 105-117. (SCI, IF2015:   3.232)

13.     Jatt AN, Tang K, Liu J, Zhang Z, Zhang   X-H*. 2015. Quorum sensing in marine snow and its possible influence on   production of extracellular hydrolytic enzymes in marine snow bacterium   Pantoea ananatis B9. FEMS Microbiol Ecol, 91, 1-13. (SCI, IF2015: 3.53)

14.     Xu T, Yu  M, Lin  H, Zhang    Z, Liu  J, Zhang  X-H*. 2015. Genomic   insight into Aquimarina longa SW024T: its ultra-oligotrophic adapting   mechanisms and biogeochemical functions. BMC Genomics, 16:772. (SCI, IF2015:   3.867)

15.     Zhang L, Wang X, Yu M, Qiao Y, Zhang   X-H*. 2015. Genomic analysis of Luteimonas abyssi XH031T: insights into   its adaption to the subseafloor environment of South Pacific Gyre and   ecological role in biogeochemical cycle. BMC Genomics, 16:1092. (SCI, IF2015:   3.867)

16.     Fu B, Liu J, Yang H, Hsu TC, He B, Dai M, Kao SJ, Zhao M, Zhang X-H*. 2014. Shift of anammox   bacterial community structure along Pearl Estuary and the impact of environmental factors. J Geophys Res –   Oceans (in printing) (SCI, IF2013:   3.44)

17.     Liu J, Yu S, Zhao M, He B, Zhang   X-H*. 2014. Shifts in archaeaplankton   community structure along ecological gradients of Pearl   Estuary. FEMS Microbiol Ecol, 90, 424-435. (SCI, IF2013: 3.875)

18.     Tang K, Zhang X-H*. 2014. Quorum quenching   agents: resources for antivirulence therapy. Mar Drugs, 12,   3245-3282. (SCI, IF2013: 3.512)

19.     Liu J, Yang H, Zhao M, Zhang X-H*.   2014. Spatial distribution patterns of benthicmicrobial   communities along Pearl Estuary. Syst Appl Microbiol. 37, 578-589. (SCI,   IF2013: 3.366)

20.   Cui F, Dong S, Shi X*, Zhao X, Zhang X-H. 2014. Overexpression and characterization of a   novel thermostable β-agarase YM01-3, from marine bacterium Catenovulum   agarivorans YM01T. Mar Drugs, 12, 2731-2747. (SCI,   IF2013: 3.512)

21.   Yuan M, Yu   Y, Li H-R, Dong N, Zhang X-H.   2014. Phylogenetic diversity and biological activity of actinobacteria   isolated from marine sediments of the Chukchi Shelf, arctic ocean. Marine   Drugs, 12, 1281-1297. (SCI, IF2013:   3.512)

22.     Yu M, Tang K, Liu J, Shi X, Gulder TAM, Zhang X-H*. 2013. Genome analysis of Pseudoalteromonas flavipulchra JG1 reveals various survival   advantages in marine environment. BMC Genomics 14:707. (SCI, IF2012: 4.397)

23.     Yin Q, Fu B, Li B, Shi X, Inagaki F and Zhang X-H*. 2013. Spatial variations in microbial community   composition in surface seawater from the ultra-oligotrophic center to rim of   the South Pacific Gyre. PLOS ONE 8(2), e55148. (SCI, IF2012: 3.73)

24.     Wang B, Yu T, Dong X, Zhang Z, Song L, Xu Y, Zhang X-H*. 2013. Edwardsiella   tarda invasion of fish cell lines and the activation of divergent cell   death pathways. Vet Microbiol, 163, 282-289 (SCI, IF2011: 3.127)

25.     Tang K, Zhang Y, Yu M, Shi X, Coenye T, Bossier P, Zhang X-H*. 2013. Evaluation of a new   high-throughput method for identifying quorum quenching bacteria. Sci Rep, 3,   2935. (SCI, IF2013: 5.078)

26.     He Y, Xu T, Fossheim LE, Zhang   X-H*. 2012. FliC, a flagellin protein, is essential for the growth and   virulence of fish pathogen Edwardsiella   tarda.  PLoS One, 7(9): e45070.   (SCI, IF2011: 4.092)

27.     Yu M, Wang J, Tang K, Shi X, Wang S, Zhu W-M* and Zhang X-H*. 2012. Purification and   characterization of antibacterial compounds of Pseudoalteromonas flavipulchra JG1. Microbiology   (SGM), 158, 835 – 842. (SCI, IF2011: 3.061)

28.     Shi X, Yu M, Yan S, Dong S,   Zhang X-H*. 2012. Genome sequence of the thermostable-agarase producting   marine bacterium Catenovulum   agarivorans YM01T, reveals the presence of a series of agarase   encoding genes. J Bacteriol, 194(19),   5484.  (SCI, IF2011: 3.825)

29.     Han Y, Yang C-L, Yang Q, Qi Z, Liu W, Xu Z-H, Zhu W-M*, Bossier P & Zhang X-H*. 2011. Mutation   of tryptophanase gene tnaA in Edwardsiella tarda reduces   lipopolysaccharide production, antibiotic resistance and virulence.   Environ Microbiol Rep, 3, 603-612. (SCI,   IF2010: 3.076)

30.     Liu R, Chen J, Li K, Zhang X-H.   2011. Identification and evaluation as a DNA vaccine candidate of a   virulence-associated serine protease from a pathogenic Vibrio parahaemolyticus isolate. Fish Shellfish Immunol, 30,   1241-1248. (SCI, IF2010: 3.044)

31.     Jia A & Zhang X-H*. 2009. Molecular cloning,   characterization and expression analysis of cathepsin D gene from turbot Scophthalmus   maximus. Fish Shellfish Immunol, 26, 606-613. (SCI,   IF2008: 3.16)

32.     Yang H, Chen J, Yang G, Zhang X-H.   2009. Protection of Japanese flounder (Paralichthys   olivaceus) against Vibrio   anguillarum with a DNA vaccine containing the mutated   zinc-metalloprotease gene. Vaccine, 27, 2150–2155. (SCI, IF2008: 3.298)

33.     Sun F, Chen J, Zhong L, Zhang   X-H, Wang R, Guo Q & Dong Y. 2008.   Characterization and virulence retention of viable but nonculturable Vibrio harveyi.  FEMS Microbiol Ecol, 64, 37-44. (SCI,   IF2007: 3.039)

34.     Sun B, Zhang X-H*, Tang X, Wang S, Zhong   Y, Chen J & Austin B. 2007.  A particular single residue   change in Vibrio harveyi hemolysin (VHH) results in the loss of   phospholipase and hemolytic activities and pathogenicity to turbot (Scophthalmus maximus).  J Bacteriol, 189, 2575-2579. (SCI, IF2007: 4.013)   

35.     Du M, Chen J, Zhang X-H, Li A, Li Y &   Wang Y. 2007. Retention   of virulence in a viable-but-nonculturable Edwardsiella tarda isolate.   Appl Environ Microbiol, 73,   1349-1354. (SCI, IF2007: 4.004)

36.     Zhong Y, Zhang X-H*, Chen J, Chi Z, Sun B, Li Y & Austin   B. 2006. Overexpression, purification, characterization and pathogenicitiy of   Vibrio harveyi hemolysin VHH.    Infect Immun, 74,   6001-6005. (SCI, IF2006: 4.004)

37.     Zhang X-H,   Axton JM, Drinjákovic J, Lorenz L, White-Cooper H & Renault AD.   2004.  Spatial and temporal control of   mitotic cyclins by the Gnuregulator of embryonic mitosis in Drosophila.   J Cell Sci, 117,   3571-3578. (SCI, IF2004: 7.250)

38.     Renault AD, Zhang X-H, Alphey LS, Frenz LM, Glover DM,   Saunders RDC & Axton JM. 2003.  giant   nuclei is essential in the cell cycle transition from meiosis to   mitosis.   Development, 130, 2997-3005. (SCI, IF2004: 7.149)

39.   Zhang X-H, Meaden PG. & Austin   B. 2001.  Duplication of hemolysin genes in a   virulent isolate of Vibrio harveyi.    Appl Environ Microbiol, 67,   3161-3167. (SCI, IF2004: 3.810)

 

Curriculum Vitae

Name:Xiao-Hua Zhang

Title: professor in Marine Microbiology

Contact

Emailxhzhang@ouc.edu.cn              Tel0086-532-82032767   (office)

Address

Colleage of Marine Life Sciences

OceanUniversity   of China

Yushan 5 Road, Qingdao 266003, China

Photo

 

Experiences:

Education

4/1998-7/2001

PhD in Microbiology,     Department of Biological Sciences, Heriot-Watt University, U.K.

9/1987-7/1990

MSc in Physiology,     Biological Department, Shandong University, China

9/1983-7/1987

BSc. in Zoology,     Biological Department, Shandong University, China

Employment and   experience

07/2004-present

Professor in Marine     Microbiology, Colleage of Marine Life Sciences, Ocean University of China,     China

11/2003-06/2004

 

Postdoctoral Researcher in Department of Genetics, Cambridge     University, U.K.

12/2000-10/2003

Postdoctoral Researcher in Department of Zoology, Oxford University,     U.K.

8/1994-4/1998

Lecturer and Associate     Professor in Marine Microbiology, Colleage of Marine Life Sciences, Ocean     University of  China, P.R. China

7/1990-8/1994

Research associate in     Shandong Institute of Marine Materia Media, China

Teaching

Teaching Microbiology, Marine   Microbiology and Modern Microbiological Methods

 

Research Interests

Marine   microbiology (including roles of marine microorganisms in driving biogeochemical   cycles; bacterial quorum sensing and quorum quenching; marine bacterial   taxonomy and  applications)