冯超

发布者:杨光发布时间:2022-01-24浏览次数:10176

冯超,博士,副教授,硕士生导师

一、联系方式:

邮箱:fengchao@ouc.edu.cn

地址:山东青岛鱼山路5号中国海洋大学海洋生命学院科学馆210

科研领域:生物医用材料、组织修复与再生、纳米技术、生物传感器、战创止血材料

二、学习与工作经历:

2020/01-至今     中国海洋大学海洋生命学院副教授

2014/09-2019.12  中国海洋大学海洋生命学院讲师

2014/09-2017/09  中国海洋大学海洋科学博士后

2012/09-2014/06  中国海洋大学海洋生命学院生物化学与分子生物学博士

2009/09-2012/06  中国海洋大学海洋生命学院生物工程硕士

2005/09-2009/06  中国海洋大学海洋生命学院生物技术学士

三、研究方向:

从事海洋生物医用材料研究,研究方向包括:医用材料的生物制造与功能化制备、组织引导再生与修复、战创止血材料、生物传感器与柔性可穿戴器件、纳米载药与递药技术。近5年主持国家自然科学基金、中国博士后基金、山东省自然科学基金、青岛市自主创新应用专项、青年教师专项基金课题共计 8项;发表学术论文60余篇,其中以第一或通讯作者发表SCI学术论文28篇,总被引1678次,h-index 25;以第一发明人授权国家发明专利6项,其中2项专利技术完成产业转化;曾获山东省海洋与渔业科学技术奖(2020)、山东省优秀博士论文(2015)、山东省研究生优秀科技创新成果奖(20142011)和教育部博士研究生学术新人奖(2012)。

四、教学工作

参与本科生课程《海洋生物功能材料》,《动物生理学实验》,研究生《生物材料与组织工程》课程讲授;作为主要完成人获中国海洋大学首届研究生教育成果二等奖(2019)。

五、社会兼职

担任中国生物材料学会会员、青岛市甲壳质研究会理事、担任Advanced Functional Materials, Advanced Healthcare Materials, ACS Nano, ACS Applied materials and interfaces, Journal of Materials Chemistry B, Carbohydrate Polymers等十余种国际学术期刊审稿人。

六、主持的科研项目情况:

1. 国家自然科学基金面上项目,金属矿化硅藻生物硅的光热-拟酶活性及其对皮肤慢性创面修复微环境的精准调控, 2022.01-2025.12,70万,在研,主持

2. 国家自然科学基金青年项目,圆筛藻生物矿化硅的促凝血机理及构效关系研究, 2019.01-2021.1224万,在研,主持

3. 山东省自然科学基金青年项目,硅藻生物矿化硅的促凝血活性及应用基础研究, 2019.07-2022.0615万,在研,主持

4. 中国博士后基金,环境响应型口服多层微分散体系的构建及抗结直肠癌作用, 2015.01-2016.125万,结题,主持

5. 山东省自然科学基金博士基金,程序化控释纳米凝胶固定化多层微分散体系的构建及抗乳腺癌作用,BS2015SW0108万,结题,主持

6. 青岛市科技发展计划,具有“表面电荷翻转”和P-gp抑制双重作用智能纳米胶束的构建及其用于抗肿瘤药物口服递送的应用基础研究, 2016.09-2018.0810万,结题,主持

7. 青岛市博士后资助,纳米凝胶固定化多层控释载体在乳腺癌口服化疗中的应用, 2015.10-2017.095万,结题,主持

8. 青年教师科研专项基金,细菌仿生硅藻基口服胰岛素递药体系的构建及其透粘膜机理的研究, 2015.01-2016.1210万,结题,主持

9. 技术转化项目,硅藻基止血粉成果相关的2项国内专利权转让, 2020.0140万,结题,主持

10. 科技服务项目,硅藻基止血粉材料专项技术服务, 2019.08-2022.0851万,在研,主持

七、代表性成果:

文章情况(第一作者及通讯作者*):

1. Chang Su, Xiaojie Sun, Yuzhi Mu, Piwu Li, Jing Li, Pengsheng Fan, Mengxue Zhang, Mengyang Wang, Xiguang Chen, Chao Feng*, Multilayer calcium alginate beads containing Diatom Biosilica and Bacillus subtilis as microecologics for sewage treatment. Carbohydrate Polymers, 2021, 256: 0-117603. IF= 9.381

2. Xiaojie Sun, Jing Li, Kai Shao, Chang Su, Shichao Bi, Yuzhi Mu, Kaichao Zhang, Zheng Cao, Xiaoye Wang, Xiguang Chen, Chao Feng*, A composite sponge based on alkylated chitosan and diatom-biosilica for rapid hemostasis. International Journal of Biological Macromolecules, 2021, 182: 2097-2107. IF= 6.953

3. Yuzhi Mu, Yangmu Fu, Jing Li, Kai Shao, Jianhui Pang, Chang Su, Yibo Cai, Xiaojie Sun, Xin Cong, Xiguang Chen, Chao Feng*, Thrombin immobilized polydopamine-diatom biosilica for effective hemorrhage control. Biomaterial Science, 2021, 9(14): 4952-4967. IF= 6.834

4. Jing Li, Xiaojie Sun, Kaichao Zhang, Guoning Yang, Yuzhi Mu, Chang Su, Jianhui Pang, Tongtong Chen, Xiguang Chen, Chao Feng*, Chitosan/Diatom-Biosilica Aerogel with Controlled Porous Structure for Rapid Hemostasis. Advanced Healthcare Materials, 2020, 9(21): e2000951. IF= 9.933Wiley旗下Materials View-China网站报道:https://www.materialsviewschina.com/2020/10/50031/

5. Kaichao Zhang, Jing Li, Yanan Wang, Yuzhi Mu, Xiaojie Sun, Chang Su, Yao Dong, Jianhui Pang, Liang Huang, Xiguang Chen, Chao Feng*, Hydroxybutyl chitosan/diatom-biosilica composite sponge for hemorrhage control. Carbohydrate Polymers, 2020, 236: 0-116051. IF= 9.381

6. Yuzhi Mu, Guangsheng Wu, ChangSu, Yao Dong, Kaichao Zhang, Jing Li, Xiaojie Sun, YangLi, Xiguang Chen, Chao Feng*, pH-sensitive amphiphilic chitosan-quercetin conjugate for intracellular delivery of doxorubicin enhancement. Carbohydrate Polymers, 2019, 223, 115072. IF= 7.182

7. Congcong Qu, Zixian Bao, Xin Zhang, Zhiguo Wang, Jizhen Ren, Zhongzheng Zhou, Meiping Tian, Xiaojie Cheng, Xiguang Chen, Chao Feng*, A thermosensitive RGD-modified hydroxybutyl chitosan hydrogel as a 3D scaffold for BMSCs culture on keloid treatment. International Journal of Biological Macromolecules, 2019, 125, 78-86.IF= 4.784

8. Changqing Jiang1, Guohui Sun1, Zhongzheng Zhou, Zixian Bao, Xuqian Lang, Jianhui Pang, Qingjie Sun, Yang Li, XinZhang, Chao Feng*, Xiguang Chen, Optimization of the preparation conditions of thermo-sensitive chitosan hydrogel in heterogeneous reaction using response surface methodology. International Journal of Biological Macromolecules, 2019, 121, 293-300.IF= 4.784

9. Lulu Wang, Kehou Pan, Jing Li, Yun Li, Baohua Zhu, Yanan Wang, Chao Feng*, Jichang Han*, Influence of the physicochemical characteristics of diatom frustules on hemorrhage control. Biomaterials science, 2019, 7, 1833-1841. IF= 5.251)(Back Cover

10. Yuzhi Mu1, Yangmu Fu1, Jing Li, Xiaoping Yu, YangLi, Yanan Wang, Xuanjin Wu, Kaichao Zhang, Ming Kong, Chao Feng*, Xiguang Chen*, Multifunctional quercetin conjugated chitosan nano-micelles with P-gp inhibition and permeation enhancement of anticancer drug. Carbohydrate Polymers, 2019, 203, 10-18. IF= 7.182

11. Guangsheng Wua1, Chao Feng1, Jingjing Quan, Zhongshan Wang, Wei Wei, Shengqi Zang, Shuai Kang, Guangyan Hui, Xiguang Chen*, Qintao Wang*, In situ controlled release of stromal cell-derived factor-1alpha and antimiR-138 for on-demand cranial bone regeneration. Carbohydrate Polymers 2018, 182, 215-224. IF= 6.044

12. Yanan Wang1, Yangmu Fu1, JingLi, Yuzhi Mu, Xin Zhang, Kaichao Zhang, Mengqi Liang, Chao Feng*, Xiguang Chen*, Multifunctional chitosan/dopamine/diatom-biosilica composite beads for rapid blood coagulation. Carbohydrate Polymers 2018, 200, 6-14. IF= 6.044

13. Guohui Sun, Xin Zhang, Zixian Bao, Xuqian Lang, Zhongzheng Zhou, Yang Li, Chao Feng*, Xiguang Chen*, Reinforcement of thermoplastic chitosan hydrogel using chitin whiskers optimized with response surface methodology. Carbohydrate Polymers, 2018, 189, 280-288. IF= 6.044

14. Jing Li1, Jichang Han1, Qingjie Sun, Yanan Wang, Yuzhi Mu, Kaichao Zhang, Xiaoyu Dou, Ming Kong, Xiguang Chen, Chao Feng*, Biosynthetic calcium-doped biosilica with multiple hemostatic properties for hemorrhage control. Journal of Materials Chemistry B, 2018, 6, 7834-7841.IF= 5.047)(Back Cover

15. Chao Feng*, Jing Li, Yuzhi Mu, Polysaccharide based multilayer micro-dispersing system as oral carriers for co-delivery of doxorubicin hydrochloride and P-gp inhibitor. Journal of Controlled Release, 2017, 259, E16-E17. (会议论文,IF= 7.877

16. Chao Feng*, Jing Li, Yuzhi Mu, Ming Kong, Yang Li, Mazhar AliRaja, Xiao Jie Cheng, Ya Liu, Xi Guang Chena*, Multilayer micro-dispersing system as oral carriers for co-delivery of doxorubicin hydrochloride and P-gp inhibitor. International Journal of Biological Macromolecules, 2017, 94, 170-180. IF= 3.909

17. Guohui Suna1, ChaoFeng1, Changqing Jiang, Tingting Zhang, Zixian Bao, Yajun Zuo, Ming Kong, Xiaojie Cheng*, Ya Liu, Xiguang Chen*, Thermo-responsive hydroxybutyl chitosan hydrogel as artery intervention embolic agent for hemorrhage control. International Journal of Biological Macromolecules, 2017, 105, 566-574. IF= 3.909

18. Yang Li1, Chao Feng1, Jing Li, Yuzhi Mu, Ya Liu, Ming Kong, Xiaojie Cheng*, XiguangChen*, Construction of multilayer alginate hydrogel beads for oral delivery of probiotics cells. International Journal of Biological Macromolecules, 2017, 105, 924-930. IF= 3.909

19. Mengxue Xu1, Chao Feng1, Juan Wang, Xuqian Lang, Guixue Xia, Xiaoping Yu, Qiuxia Ji, Xiaojie Cheng, Ming Kong, Ya Liu, Xiguang Chen*, In vitro heterogeneous degradation of alginate and its validation of different molecular weight on blood biocompatibility, Journal of Biomaterials Science, Polymer Edition, 2017, 28: 380–393.IF= 1.911

20. Chao Feng*, Jing Li, Guang Sheng Wu, Yu Zhi Mu, Ming Kong, Chang Qing Jiang, Xiao Jie Cheng, Ya Liu, Xi Guang Chen*, Chitosan-Coated Diatom Silica as Hemostatic Agent for Hemorrhage Control. ACS Applied Materials & Interfaces, 2016, 8, 34234-34243. IF= 7.504

21. Guangsheng Wu1, Chao Feng1, Guangyan Hui, Zhongshan Wang, Jun Tan, Lankun Luo, Peng Xue, Qintao Wang*, XiguangChen*, Improving the osteogenesis of rat mesenchymal stem cells by chitosan-based-microRNA nanoparticles. Carbohydrate Polymers, 2016, 138, 49-58. IF= 4.811

22. Juan Wang, Mengxue Xu, Xiaojie Cheng, Ming Kong, Ya Liu, Chao Feng*, Xiguang Chen*, Positive/negative surface charge of chitosan based nanogels and its potential influence on oral insulin delivery. Carbohydrate Polymers, 2016, 136, 867-874. IF= 4.811

23. Jing Li, Changqing Jiang, Xuqian Lang, Ming Kong, Xiaojie Cheng, Ya Liu, Chao Feng*, Xiguang Chen*, Multilayer sodium alginate beads with porous core containing chitosan based nanoparticles for oral delivery of anticancer drug. International Journal of Biological Macromolecules, 2016, 85, 1-8. IF= 3.671

24. Chao Feng*, Jing Li, Ming Kong, Ya Liu, Xiao Jie Cheng, Yang Li, Hyun JinPark, Xi Guang Chen*, Surface charge effect on mucoadhesion of chitosan based nanogels for local anti-colorectal cancer drug delivery. Colloids and surfaces. B, Biointerfaces, 2015, 128, 439-447. IF= 3.902

25. Chao Feng, Guohui Sun, Zhiguo Wang, Xiaojie Cheng, Hyunjin Park, Dongsu Cha, Ming Kong*, Xiguang Chen*. Transport mechanism of doxorubicin loaded chitosan based nanogels across intestinal epithelium, European Journal of Pharmaceutics and Biopharmaceutics, 2014, 87, 197-20. IF= 3.383

26. Guohui Sun1, Chao Feng1, Ming Kong, Xiaojie Cheng, Jiaojiao Bing, Guixue Xia, Zixian Bao, Hyunjin Park*, and Xiguang Chen*, Development of part-dissolvable chitosan fibers with surface N-succinylation for wound care dressing, Frontiers of Materials Science, 2015, 9: 272-281. IF= 1.354

27. Chao Feng, Ruixi Song, Guohui Sun, Ming Kong, Yang Li, Zixian Bao, Xiaojie Cheng, Dongsu Cha, Hyunjin Park*, Xiguang Chen*. Immobilization of coacervate microcapsules in multilayer sodium alginate beads for efficient oral anticancer drug delivery, Biomacromolecules, 2014, 15, 985-996. IF= 5.750

28. Chao Feng, Zhiguo Wang, Changqing Jiang, Ming Kong, Xuan Zhou, Yang Li, Xiaojie Cheng*, Xiguang Chen*, Chitosan/o-carboxymethyl chitosan nanoparticles for efficient and safe oral anticancer drug delivery: in vitro and in vivo evaluation, International Journal of Pharmaceutics, 2013, 457, 158-167. IF= 3.785

国家发明专利:

1. 冯超、王雅楠、陈西广、孔明、程晓杰、刘雅,一种氨基聚糖/多巴胺/硅藻生物矿化硅复合多孔止血胶球的制备方法,国家发明专利、ZL201810658576.5

2. 冯超、李静、陈西广、孔明、程晓杰、刘雅, 一种氨基聚糖修饰硅藻基止血粉的制备方法,国家发明专利、ZL201610494583.7(已转化)

3. 冯超、李静、陈西广、孔明、程晓杰、刘雅,一种金属阳离子修饰天然硅藻细胞膜止血粉的制备方法,国家发明专利、ZL201610732723.X(已转化)

4. 冯超、穆愈之、陈西广、孔明 、程晓杰、刘雅,一种具有黏液层渗透和P-gp抑制双重作用纳米胶束的制备方法,国家发明专利、ZL2016104945818

5. 冯超、穆愈之、孔明、陈西广、程晓杰、刘雅,一种酶触响应性控释盐酸阿霉素的壳聚糖基复合纳米微粒的制备方法,国家发明专利、ZL201610646912.

6. 冯超、李静、陈西广、孔明,一种羧甲基壳聚糖纳米微粒固定化多孔多层海藻酸钠胶球的制备方法,国家发明专利、ZL2016104555380