王孟强

王孟强

博士/副教授/硕士研究生导师

研究领域：水产生物安保与病害防治技术

研究方向：

（1）胞外囊泡在水产动物与病原相互作用中的功能

（2）水产养殖生物病原实用化检测与抗病育种技术

（3）新型免疫增强剂在水产动物健康养殖中的应用

招生专业：

（1）海洋生命学院：071000、071300、086001

（2）三亚海洋研究院：071000、086001

邮箱：wangmengqiang@ouc.edu.cn

工作及教育经历：

2019年10月-今 中国海洋大学海洋生命学院 副教授（“青年英才工程”第二层次）

2019年10月-今 中国海洋大学三亚海洋研究院 副教授（柔性引进）

2017年12月-今 海洋试点国家实验室分子生物平台 副主任（双聘）

2013年12月-2019年09月 中国科学院海洋研究所 副研究员

2012年11月-2013年12月 中国科学院海洋研究所 助理研究员

2012年08月-2012年11月 中国科学院海洋研究所 研究实习员

2010年07月-2012年08月 中国科学院海洋研究所 博士后

2007年09月-2010年06月 中国科学院海洋研究所 海洋生物学 博士

2004年09月-2007年06月 中国海洋大学海洋生命学院 海洋生物学 硕士

2001年09月-2004年06月 中国海洋大学海洋生命学院 生物科学 学士

主要科研项目：

1. 国家自然科学基金青年基金，LRR-only蛋白对栉孔扇贝免疫应答的调控作用，主持

2. 国家自然科学基金面上项目，外泌体对长牡蛎抗灿烂弧菌免疫应答的调控机制，主持

3. 国家自然科学基金面上项目，脂多糖刺激下栉孔扇贝外泌体对自噬的调控作用及其分子机制，主持

4.国家重点研发计划课题，海水南美白对虾、扇贝优异种质资源鉴定，主持

5. 海南省科技计划三亚崖州湾科技城联合项目，CpG ODNs介导的凡纳滨对虾肠道菌群结构免疫调节机制，主持

6. 中国海洋大学“青年英才工程”科研启动经费项目，对虾外泌体在宿主与病原相互作用中的功能研究，主持

7. 国家重点研发计划课题，水产品质量安全保障技术应用示范，参与

8. 山东省重大科技创新工程项目（驻鲁部属高校“十四五”服务山东重点建设项目），虾、贝分子育种技术体系构建与新品种培育，参与

9. 海南省三亚崖州湾科技城管理局重大科技项目，海南重要水产养殖动物全基因组育种技术平台研发，参与

10. 海南省三亚崖州湾科技城管理局重大科研项目，热带水产养殖生物育种材料创制与新品种选育，参与

11.海南省崖州湾种子实验室科技计划项目，高抗速生南美白对虾新品种选育，参与

12. 中央高校基本科研业务费项目，热带海洋生物种质资源库建设，参与

主要学术论文：

到目前为止（2021年12月31日），在相关领域累计发表学术论文近130篇，包括第一作者论文25篇，（共同）通讯作者论文12篇，主要论文如下：

第一作者论文：

1. Wang Mengqiang, Hu Jingjie, Zhuang Yunyun, Zhang Lei, Liu Wei, Mao Yunxiang*. 2007. In silico screening for microsatellite markers from expressed sequence tags of Porphyra yezoensis (Bangiales, Rhodophyta). Journal of Ocean University of China. 6: 161-166.

2. 王孟强, 茅云翔*, 李杰, 张蕾, 刘玮, 庄昀筠. 2007. 甘紫菜细胞色素c₆基因petJ克隆与序列分析. 中国海洋大学学报. 37s: 156-166.

3. Wang Mengqiang, Mao Yunxiang*, Zhuang Yunyun, Kong Fanna, Sui Zhenghong. 2009. Cloning and analysis of calmodulin gene from Porphyra yezoensis Ueda (Bangiales, Rhodophyta). Journal of Ocean University of China. 8: 247-253.

4. Wang Mengqiang, Yang Jialong, Zhou Zhi, Qiu Limei, Wang Lingling, Zhang Huan, Gao Yang, Wang Xingqiang, Zhang Li, Zhao Jianmin, Song Linsheng*. 2011. A primitive Toll-like receptor signaling pathway in mollusk Zhikong scallop Chlamys farreri. Developmental & Comparative Immunology. 35: 511-520.

5. Wang Mengqiang, Zhang Daoxiang, Wang Lingling, Gai Yunchao, Zhou Zhi, Zhang Huan, Song Linsheng*. 2013. The molecular characterization of a cyclophilin A from Chinese mitten crab Eriocheir sinensis and the antifungal activity of its recombinant protein. Electronic Journal of Biotechnology. 16: 5.

6. Wang Mengqiang, Wang Lingling*, Zhou Zhi, Gao Yang, Wang Leilei, Shi Xiaowei, Gai Yunchao, Mu Changkao, Song Linsheng*. 2013. The molecular characterization of a catalase from Chinese mitten crab Eriocheir sinensis. International Journal of Immunogenetics. 40: 230-240.

7. Wang Mengqiang, Wang Lingling, Guo Ying, Zhou Zhi, Yi Qilin, Zhang Daoxiang, Zhang Huan, Liu Rui, Song Linsheng*. 2014. A high mobility group box 1 (HMGB1) gene from Chlamys farreri and the DNA-binding ability and pro-inflammatory activity of its recombinant protein. Fish & Shellfish Immunology. 36: 393-400.

8. Wang Mengqiang, Wang Lingling, Guo Ying, Sun Rui, Yue Feng, Yi Qilin, Song Linsheng*. 2015. The broad pattern recognition spectrum of the Toll-like receptor in mollusk Zhikong scallop Chlamys farreri. Developmental & Comparative Immunology. 52: 192-201.

9. Wang Mengqiang, Wang Lingling, Yi Qilin, Gai Yunchao, Song Linsheng*. 2015. Molecular cloning and characterization of a cytoplasmic manganese superoxide dismutase and a mitochondrial manganese superoxide dismutase from Chinese mitten crab Eriocheir sinensis. Fish & Shellfish Immunology. 47: 407-417.

10. Wang Mengqiang, Wang Lingling*, Guo Ying, Yi Qilin, Song Linsheng. 2016. An LRR-only protein representing a new type of pattern recognition receptor in Chlamys farreri. Developmental & Comparative Immunology. 54: 145-155.

11. Wang Mengqiang, Wang Lingling*, Xin Lusheng, Wang Xiudan, Wang Lin, Xu Jianchao, Jia Zhihao, Yue Feng, Wang Hao, Song Linsheng. 2016. Two novel LRR-only proteins in Chlamys farreri: similar in structure, yet different in expression profile and pattern recognition. Developmental & Comparative Immunology. 59: 99-109.

12. Wang Mengqiang, Wang Lingling, Huang Mengmeng, Yi Qilin, Guo Ying, Gai Yunchao, Wang Hao, Zhang Huan, Song Linsheng*. 2016. A galectin from Eriocheir sinensis functions as pattern recognition receptor enhancing microbe agglutination and haemocytes encapsulation. Fish & Shellfish Immunology. 55: 10-20.

13. Wang Mengqiang,Wang Baojie, Jiang Keyong, Liu Mei, Han Siyin, Wang Lei*. 2017. Molecular characterization and transcriptional analysis of a crustacean heat shock protein 10 gene in shrimp Litopenaeus vannamei. ISJ-Invertebrate Survival Journal. 14: 404-413.

14. Wang Mengqiang, Wang Baojie, Liu Mei, Jiang Keyong, Wang Lei*. 2017. A novel macrophage migration inhibitory factor gene from the Pacific white shrimp Litopenaeus vannamei (LvMIF2): comparative sequence and transcription analysis with LvMIF1. ISJ-Invertebrate Survival Journal. 14: 453-463.

15. Wang Mengqiang, Wang Lingling, Jia Zhihao, Wang Xiudan, Yi Qilin, Lv Zhao, Song Linsheng*. 2017. The versatile functions of LRR-only proteins in mollusk Chlamys farreri. Developmental & Comparative Immunology. 77: 188-199.

16. Wang Mengqiang, Wang Baojie, Liu Mei, Jiang Keyong, Wang Lei*. 2018. Sequence features, expression profiles and biochemical characteristics of a sigma class glutathione S-transferase gene (AiGSTσ) from bay scallop Argopecten irradians. ISJ-Invertebrate Survival Journal. 15: 19-30.

17. Wang Mengqiang, Wang Baojie, Jiang Keyong, Liu Mei, Shi Xiaowei, Wang Lei*. 2018. A mitochondrial manganese superoxide dismutase involved in innate immunity is essential for the survival of Chlamys farreri. Fish & Shellfish Immunology. 72: 282-290.

18. Wang Mengqiang, Wang Lingling, Jia Zhihao, Yi Qilin, Song Linsheng*. 2018. The various components implied the diversified Toll-like receptor (TLR) signaling pathway in mollusk Chlamys farreri. Fish & Shellfish Immunology. 74: 205-212.

19. Wang Mengqiang, Liu Mei, Wang Baojie, Jiang Keyong, Jia Zhihao, Wang Lingling*, Wang Lei*. 2018. Transcriptomic analysis of exosomal shuttle mRNA in Pacific oyster Crassostrea gigas during bacterial stimulation. Fish & Shellfish Immunology. 74: 540-550.

20. Wang Mengqiang, Wang Baojie, Liu Mei, Jiang Keyong, Wang Lei*. 2018. An i-type lysozyme (CfLyzI) involved in innate immunity is essential for the survival of Chlamys farreri during Vibrio stimulation. ISJ-Invertebrate Survival Journal. 15: 285-293.

21. Wang Mengqiang, Wang Baojie, Liu Mei, Jiang Keyong, Wang Lei*. 2018. Molecular characterization of a defender against apoptotic cell death 1 gene (CfDAD1) from the mollusk Chlamys farreri. ISJ-Invertebrate Survival Journal. 15: 294-301.

22. Wang Mengqiang, Wang Lingling, Ni Duojiao, Yi Qilin, Wang Xiudan, Jia Zhihao, Song Linsheng*. 2018. The mRNA expression profiles demonstrating versatile roles of glutathione S-transferase genes in the mollusk Chlamys farreri. ISJ-Invertebrate Survival Journal. 15: 302-315.

23. Wang Mengqiang, Wang Baojie, Liu Mei, Jiang Keyong, Wang Lei*. 2019. Comparative study of β-thymosin in two scallop species Argopecten irradians and Chlamys farreri. Fish & Shellfish Immunology. 86: 516-524.

24. Wang Mengqiang, Wang Baojie, Liu Mei, Jiang Keyong, Wang Lei*. 2019. A novel LRR-only protein mediates the proliferation of hemolymph microbiota via regulating the expression of antimicrobial peptides in mollusk Chlamys farreri. Developmental & Comparative Immunology. 92: 223-229.

25. Wang Mengqiang, Wang Baojie, Liu Mei, Jiang Keyong, Wang Lei*. 2019. The first identification of a malectin gene (CfMal) in scallop Chlamys farreri: sequence features and expression profiles. ISJ-Invertebrate Survival Journal. 16: 25-33.

（共同）通讯作者论文：

1. Wang Yilong, Wang Baojie, Liu, Mei, Jiang Keyong, Wang Mengqiang*, Wang Lei*. 2018. Aflatoxin B1 (AFB1) induced dysregulation of intestinal microbiota and damage of antioxidant system in pacific white shrimp (Litopenaeus vannamei). Aquaculture. 495: 940-947.

2. Shao Jianchun, Wang Baojie, Liu Mei, Jiang Keyong, Wang Lei*, Wang Mengqiang*. 2019. Replacement of fishmeal by fermented soybean meal could enhance the growth performance but not significantly influence the intestinal microbiota of white shrimp Litopenaeus vannamei. Aquaculture. 504: 354-360.

3. Wang Xiudan, Zhao Xiaoli, Yan Chunyu, Jia Zhihao, Lv Zhao, Ma Cuiping, Wang Mengqiang*. 2019. A novel LRR and Ig domain-containing protein could function as an immune effector in Crassostrea gigas. Fish & Shellfish Immunology.88: 318-327.

4. Wang Yilong, Wang Baojie, Liu, Mei, Jiang Keyong, Wang Mengqiang*, Wang Lei*. 2019. Comparative transcriptome analysis reveals the different roles between hepatopancreas and intestine of Litopenaeus vannamei in immune response to aflatoxin B1 (AFB1) challenge. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology. 222:1-10.

5. Wang Yilong, Wang Baojie, Shao Xuqing, Shao Jianchun, Liu Mei, Wang Mengqiang*, Wang Lei*. 2019. The effect of rearing density on immune responses of hepatopancreas and intestine in Litopenaeus vananmei against Vibrio paraheamolyticus E1 challenge. Fish & Shellfish Immunology. 93: 517-530.

6. Wang Yilong, Liu Mei, Wang Baojie, Jiang Keyong, Wang Mengqiang*, Wang Lei*. 2019. A global view of hepatopancreas and intestinal reveals the potential influencing mechanism of aflatoxin B1 on nutrition and metabolism in Litopenaeus vannamei. Aquaculture Nutrition, 25: 1354-1366. 

7. Wang Yilong, Liu Mei, Wang Baojie, Jiang Keyong, Wang Mengqiang*, Wang Lei*. 2020. Response of the Litopenaeus vananmei intestinal bacteria and antioxidant system to rearing density and exposure to Vibrio paraheamolyticus E1. Journal of Invertebrate Pathology, 170: 107326. 

8. Wang Yan, Wang Baojie, Shao Xuqing, Liu Mei, Jiang Keyong, Wang Mengqiang*, Wang Lei*. 2020. A comparative transcriptomic analysis in late embryogenesis of the red claw crayfish Cherax quadricarinatus. Molecular Genetics and Genomics, 295: 299-311. 

9. Han Siyi, Wang Lei, Wang Yilong, Chen Yang, Wang Baojie*, Wang Mengqiang*, Lin Jiang*. 2020. Effects of the glutathione administration via dietary on intestinal microbiota of white shrimp, Penaeus vannamei, under cyclic hypoxia conditions. ISJ-Invertebrate Survival Journal. 17: 36-50.

10. Wang Yan, Wang Baojie, Liu Mei, Jiang Keyong, Wang Mengqiang*, Wang Lei*. 2020. The first identification of a C-type lectin gene (CqCTL) in Cherax quadricarinatus: sequence features and expression profiles. ISJ-Invertebrate Survival Journal. 17: 108-116.

11. Wang Yan, Wang Baojie, Shao Xuqing, Liu Mei, Jiang Keyong, Wang Mengqiang*, Wang Lei*. 2020. Identification and profiling of microRNAs during embryogenesis in the red claw crayfish Cherax quadricarinatus. Frontiers in Physiology. 11: 878.

12. Wang Yan, Wang Baojie, Liu Mei, Jiang Keyong, Wang Mengqiang*, Wang Lei*. 2021. Characterization and function analysis of a Kazal-type serine proteinase inhibitor in the red claw crayfish Cherax quadricarinatus. Developmental & Comparative Immunology. 114: 103871.

论文清单：

https://scholar.google.com/citations?user=s_GIjigAAAAJ&hl=zh-CN