胡晓丽 博士，教授，博士生导师
研究方向：贝类分子遗传学
一、学习及工作经历
1989.9－1993.7 青岛海洋大学水产学院食品工程专业，获学士学位
1993.9－2000.8 青岛市农业科学研究所工作
2000.9－2005.6 中国海洋大学海洋生命学院海洋生物学专业，获博士学位
2005.7－至今 中国海洋大学海洋生命学院工作
2009.8－2010.8 美国斯坦福大学生物系访问学者
二、近三年主要科研项目
1. 国家重点基础研究发展规划项目计划（973计划）：贝类分子设计育种的关键技术研究（2010CB126406），2012-2014，主持
2. 国家自然科学基金：引种日本皱纹盘鲍对我国本土种质资源遗传结构影响的研究（41176118），2012-2015，主持
3. 国家自然科学基金：栉孔扇贝抑肌素myostatin及其信号途径基因的表达调控（30972239），2010-2012，主持
4. 国家高技术研究发展计划（863计划）重大项目：海洋生物分子细胞育种关键技术（2012AA10A402），2012-2015，第二位
5. 国家重点基础研究发展规划项目计划（973计划）：贝类SNP规模发掘及高密度遗传连锁图谱的构建（2010CB126402），2010-2011，第三位
三、近五年发表论文（*通讯作者）
1. Liying Feng, Xue Li, Qian Yu, Xianhui Ning, Jinzhuang Dou, Jiajun Zou, Lingling Zhang, Shi Wang, Xiaoli Hu*, Zhenmin Bao*. A Scallop IGF Binding Protein Gene: Molecular Characterization and Association of Variants with Growth Traits. PLoS ONE. 2014; 9(2): e89039.
2. Wenqian Jiao, Xiaoteng Fu, Jinqin Li, Ling Li, Liying Feng, Jia Lv, Lu Zhang, Xiaojian Wang, Yangping Li, Rui Hou, Lingling Zhang, Xiaoli Hu, Shi Wang*, Zhenmin Bao*. Large-scale development of gene-associated single-nucleotide polymorphism markers for molluscan population genomic, comparative genomic, and genome-wide association studies. DNA Research. 2014. 21(2):183-193.
3. Xiaoteng Fu, Yan Sun, Jing Wang, Qiang Xing, Jiajun Zou, R Li, Z Wang, Shi Wang, Xiaoli Hu, Lingling Zhang*, Zhenmin Bao*. Sequencing-based gene network analysis provides a core set of gene resource for understanding thermal adaptation in Zhikong scallop Chlamys farreri. Molecular Ecology Resources. 2014. 14(1): 184–198.
4. Yueyue Zhang, Lingling Zhang, Jin Sun, Jianwen Qiu, Xiaoli Hu, Jingjie Hu, Zhenmin Bao*. Proteomic analysis identifies proteins related to carotenoid accumulation in Yesso scallop (Patinopecten yessoensis). Food Chemistry. 2014. 147: 111-116.
5. Jessica Chang, Yiqi Zhou, Xiaoli Hu, Lucia Lam, Cameron Henry, Erin M. Green, Ryosuke Kita, Michael S. Kobor, Hunter B. Fraser*. The molecular mechanism of a cis-regulatory adaptation in yeast. PLoS Genetics. 2013. 9(9):e1003813.
6. Jia Lv, Liying Feng, Zhenmin Bao, Huihui Guo, Yueyue Zhang, Wenqian Jiao, Lingling Zhang, Shi Wang, Yan He*, Xiaoli Hu*. Molecular characterization of RXR (Retinoid X Receptor) gene isoforms from the bivalve species Chlamys farreri. PLoS ONE. 2013. 8(9): e74290.
7. Liying Feng, Qian Yu, Xue Li, Xianhui Ning, Jing Wang, Jiajun Zou, Lingling Zhang, Shi Wang, Jingjie Hu, Xiaoli Hu*, Zhenmin Bao. Identification of reference genes for qRT-PCR analysis in Yesso scallop Patinopecten yessoensis. PLoS ONE. 2013. 8(9): e75609.
8. Yan He, Zhenmin Bao, Huihui Guo, Yueyue Zhang, Lingling Zhang, Shi Wang, Jingjie Hu, Xiaoli Hu*. Molecular cloning and characterization of SoxB2 gene from Zhikong scallop Chlamys farreri. Chinese Journal of Oceanology and Limnology. 2013. 31(6):1216-1225.
9. Shan Wang, Rui Hou, Zhenmin Bao, Huixia Du, Yan He, Hailin Su, Yueyue Zhang, Xiaoteng Fu, Wenqian Jiao, Yan Li, Lingling Zhang, Shi Wang*, Xiaoli Hu*. Transcriptome sequencing of Zhikong Scallop (Chlamys farreri) and comparative transcriptomic analysis with Yesso Scallop (Patinopecten yessoensis). PLoS ONE. 2013. 8(5): e63927.
10. Jiqin Li, Zhenmin Bao, Ling Li, Xiaojian Wang, Shi Wang, Xiaoli Hu*. Development of 101 novel EST-derived single nucleotide polymorphism markers for Zhikong scallop, Chlamys farreri. Journal of Ocean University of China. 2013. 12 (3): 403-412.
11. Huihui Guo, Zhenmin Bao, Huixia Du, Lingling Zhang, Shi Wang, Luyang Sun, Xiaoyu Mou, Xiaoli Hu*. Identification of Cytochrome P450 (CYP) Genes in Zhikong Scallop (Chlamys farreri). Journal of Ocean University of China. 2013. 12(1): 97-102.
12. Junxia Mao, Jia Lv, Yan Miao, Changsen Sun, Liping Hu, Ru Zhang, Xiaoteng Fu, Lingling Zhang, Xiaoli Hu, Shi Wang*, Zhenmin Bao*. Development of a rapid and efficient method for non-lethal DNA sampling and genotyping in scallops. PLoS ONE. 2013. 8(7): e68096.
13. Xiaoteng Fu, Jinzhuang Dou, Junxia Mao, Hailin Su, Wenqian Jiao, Lingling Zhang, Xiaoli Hu, Xiaoting Huang, Shi Wang*, Zhenmin Bao*. RADtyping: An Integrated Package for Accurate De Novo Codominant and Dominant RAD Genotying in Mapping Populations. PLoS One. 2013. 8(11): e79960.
14. Wenqian Jiao, Xiaoteng Fu, Jinzhuang Dou, Hengde Li, Hailin Su, Junxia Mao, Qian Yu, Lingling Zhang, Xiaoli Hu, Xiaoting Huang, Yangfan Wang, Shi Wang*, Zhenmin Bao*. High-resolution linkage and quantitative trait locus mapping aided by genome survey sequencing: Building up an integrative genomic framework for a bivalve mollusc. DNA Research. 2013. Doi: 10.1091/dnares/dst043.
15. Yueyue Zhang, Ru Zhang, Jiajun Zou, Xiaoli Hu, Shi Wang, Lingling Zhang*, Zhenmin Bao*. Identification and characterization of four ferritin subunits involved in immune defense of the Yesso scallop (Patinopecten yessoensis). Fish and Shellfish Immunology. 2013. 34: 1178-1187.
16. 李纪勤, 包振民*, 李玲, 胡晓丽. 栉孔扇贝EST-SNP标记开发及多态性分析. 中国海洋大学学报. 2013. 43(1): 56-63.
17. 窦锦壮, 赵熙强, 付晓腾, 焦文倩, 王南南, 张玲玲, 胡晓丽, 王师*, 包振民. 测序错误和重复序列对无参照基因组单核苷酸多态性分型的影响. 中国海洋大学学报. 2013. 43(5):120-124.
18. 郭慧慧, 包振民, 连珊珊, 贺艳, 胡晓丽*. 栉孔扇贝骨形态发生蛋白I型受体基因的克隆及表达分析. 中国海洋大学学报. 2013. 43(5): 37-43.
19. 吕佳，侯睿，李宁，王宸，张玲玲，胡晓丽，王师，包振民*. 应用MSAP技术研究扇贝全基因组DNA甲基化水平. 中国海洋大学学报. 2013. 43(8): 48-53.
20. 封利颖, 郭慧慧, 李雪, 于茜, 胡晓丽, 张玲玲, 王师, 包振民*. 栉孔扇贝骨形态发生蛋白2基因的克隆及表达分析. 中国海洋大学学报. 2013. 43(12): 48-55.
21. Huihui Guo, Zhenmin Bao, Jiqin Li, Shanshan Lian, Shi Wang, Yan He, Xiaoteng Fu, Lingling Zhang, Xiaoli Hu*. Molecular characterization of TGF-β Type I receptor gene (Tgfbr1) in Chlamys farreri, and the association of allelic variants with growth traits. PLoS ONE. 2012. 7(11): e51005.
22. Xiaojian Wang, Xiaoli Hu, Jiqin Li, Ling Li, Rui Hou, Shi Wang, Lingling Zhang*, Zhenmin Bao. Characterization of 38 EST-derived SNP markers in Zhikong scallop (Chlamys farreri) and their cross-species utility in Yesso scallop (Patinopecten yessoensis). Conservation Genetics Resources. 2012. 4:747–753.
23. Lingling Zhang, Rui Hou, Hailin Su, Xiaoli Hu, Shi Wang*, Zhenmin Bao*. Network analysis of Oyster transcriptome revealed a cascade of cellular responses during recovery after heat shock. PLoS ONE. 2012. 7(4): e35484.
24. Qinglei Meng, Zhenmin Bao, Zhaoping Wang, Shi Wang, Jingjie Hu, Xiaoli Hu,Xiaoting Huang*. Growth and reproductive performance of triploid Yesso scallops (Patinopecten yessoensis) induced by hypotonic shock. Journal of Shellfish Research. 2012. 31 (4): 1-10.
25. Jinzhuang Dou, Xiqiang Zhao, Xiaoteng Fu, Wenqian Jiao, Nannan Wang, Lingling Zhang, Xiaoli Hu, Shi Wang, Zhenmin Bao*. Reference-free SNP calling: Improved accuracy by preventing incorrect calls from repetitive genomic regions. Biology Direct. 2012. 7: 17.
26. Huixia Du, Zhenmin Bao, Rui Hou, Shan Wang, Hailin Su, Jingjing Yan, Meilin Tian, Yan Li, Wen Wei, Wei Lu, Xiaoli Hu, Shi Wang*, Jingjie Hu*. Transcriptome sequencing and characterization for the sea cucumber Apostichopus japonicas (Selenka, 1867). PLoS ONE. 2012. 7(3): e33311.
27. Rui Hou, Zhenmin Bao, Shan Wang, Hailin Su, Yan Li, Huixia Du, Jingjie Hu, Shi Wang*, Xiaoli Hu*. Transcriptome sequencing and De Novo analysis for Yesso Scallop (Patinopecten yessoensis) using 454 GS FLX. PLoS ONE. 2011. 6(6): e21560.
28. 包振民*，王明玲，李艳，张玲玲，胡晓丽，黄晓婷，胡景杰，王师. 基于核基因组标记的群体遗传学研究中的数学分析方法. 中国海洋大学学报. 2011. 41(11): 48-56.
29. Xiaoli Hu, Huihui Guo, Yan He, Shan Wang, Lingling Zhang, Shi Wang, Xiaoting Huang, Scott William Roy, Wei Lu, Jingjie Hu*, Zhenmin Bao. Molecular characterization of myostatin gene from Zhikong scallop Chlamys farreri (Jones et Preston 1904). Genes & Genetic Systems. 2010. 85(3): 207-218.
30. Ning Li, Jingjie Hu, Shan Wang, Jie Cheng, Xiaoli Hu, Zhenyu Lu, Zhenjian Lin, Weiming Zhu, Zhenmin Bao*. Isolation and identification of the main carotenoid pigment from the rare orange muscle of the Yesso scallop. Food Chemistry. 2010. 118: 616-619.
31. Aibin Zhan, Jingjie Hu, Xiaoli Hu, Min Hui, Mingling Wang, Wei Peng, Xiaoting Huang , Shi Wang, Wei Lu, Changsen Sun and Zhenmin Bao*. Construction of microsatellite-based linkage maps and identification of size-related quantitative trait loci for Zhikong scallop (Chlamys farreri). Animal Genetics. 2009. 40: 821-831.
32. Aibin Zhan, Jingjie Hu, Xiaoli Hu, Zunchun Zhou, Min Hui, Shi Wang，Wei Peng， Mingling Wang，Zhenmin Bao*. Fine-scale population genetic structure of zhikong scallop (Chlamys farreri): Do local marine currents drive geographical differentiation? Marine Biotechnology. 2009. 11: 223-235.
33. Aibin Zhan, Zhenmin Bao, Xiaoli Hu, Wei Lu, Jingjie Hu. Methods comparison for microsatellite marker development: different isolation methods, different yield efficiency. Journal of Ocean University of China. 2009. 8(2):161-165.
34. 孟庆磊, 黄晓婷, 赵海波, 赵婷, 李宁, 王昭平, 胡晓丽*, 胡景杰, 包振民. 扇贝异源三倍体诱导.中国水产科学. 2009. 16(5): 718-727.
35. 胡景杰, 战爱斌, 胡晓丽, 陆维, 黄晓婷, 包振民*. 几种养殖扇贝微卫星标记的研究进展.水产学报. 2009. 33(2): 348-356.
四、专利
1. 胡晓丽, 包振民, 黄晓婷, 王师, 张玲玲, 陆维, 王扬帆. 一种饵料藻自动培养与投加装置（专利号：201320395073.6）
2. 黄晓婷, 胡晓丽, 王师, 张玲玲, 孟庆磊, 王珊, 包振民, 胡景杰. 一种栉孔扇贝基因的染色体定位方法（专利号：ZL 200810138645.6）
3. Zhenmin Bao, Shan Wang, Ning Li, Jingjie Hu, Rui Hou, Xiaoliang Ren, Xiaoli Hu, Wei Lu. Breeding Method for Orange-Adductor-Muscle Scallop. (美国专利号：US8544415B2)
4. 包振民, 王珊, 胡景杰, 胡晓丽, 李纪勤, 侯睿, 付晓腾, 陆维. 一种大规模筛查扇贝SNP的方法（专利号：ZL 200910231573.4）
5. 包振民, 王珊, 吴厚刚, 胡景杰, 李宁, 侯睿, 任晓亮, 胡晓丽, 陆维. 一种橘红色闭壳肌扇贝的培育方法（专利号：ZL 200910231570.0）
6. 包振民, 胡晓丽, 张玲玲, 王师, 郭慧慧, 张月月. 栉孔扇贝TGF-ß I型受体基因及其SNP位点（申请号：201210439861.0）
7. 包振民, 胡晓丽, 张玲玲, 王师, 黄晓婷, 王扬帆, 陆维.一种饵料藻自动培养与投加方法（申请号：201310097183.9）
8. 包振民, 张月月, 张玲玲, 胡晓丽, 陆维. 虾夷扇贝铁蛋白基因及其应用（申请号：201210385015.5）
五、奖励及称号
1. 教育部新世纪人才（2009）
2. 国家科技进步二等奖（第6受奖人，2008）
3. 教育部科技进步一等奖（第3受奖人，2007）
4. 青岛市科技进步一等奖（第3受奖人，2007）
5. 中国海洋大学“五四”青年奖（2008）
联系方式
电话：0532-82031970
邮箱：hxl707@ouc.edu.cn
地址：青岛市鱼山路5号中国海洋大学化学馆224室
