一、张士璀教授简介
男，江苏泗阳人。中国海洋大学教授、博士生导师、国务院特殊津贴获得者、全国模范教师、山东省泰山学者、山东省有突出贡献专家和山东省优秀科技工作者并记二等功，海洋生物多样性与进化研究所副所长。国外学习和工作经历包括：加拿大多伦多大学博士后，美国Scripps海洋研究所高级访问学者，日本鹿儿岛大学JSPS Fellow和英国Essex大学高级访问学者。曾任海洋生命学院副院长、院长、教育部生物科学教学指导委员会成员、国际生物学联合会委员、山东省第十一届人大常委；现任《Mar. Biotech.》、《Acta Oceanol. Sin.》和《Chin. J. Oceanol. Limnol.》等期刊编委、山东省政协常委、山东省细胞生物学学会副理事长和山东省动物学学会副理事长。
二、主要学术成就
主编《海洋生物技术和原理》和《海洋生物技术新进展》专著2部；编写《发育生物学》和《细胞工程学》教材2本；参编英文专著《Reproductive Biology and Phylogenyof Fishes》1本。已发表SCI收录论文200余篇。证明文昌鱼肝盲囊与脊椎动物肝脏具有同源性，发现文昌鱼存在脊椎动物样垂体-肝脏轴；首次报道卵黄蛋白原和高磷蛋白具有免疫功能，被国外同行认为是“新发现”（new findings）和“新观察”（novel observations）。已获国家科技发明二等奖1项、山东省自然科学一等奖1项、教育部自然科学一等奖1项和国家海洋局海洋创新成果一等奖1项。
三、研究方向
1文昌鱼进化与发育生物学
2鱼类发育与衰老
四、主持的在研课题
国家联合基金项目“免疫增强剂促进石斑鱼免疫分子和免疫力亲子传递之基础研究”，260万；2015-2018
国家基金面上项目“鱼类新母源性免疫因子的分离、鉴定与作用机理”，77万；2014-2017
国家重大基础研究计划（973）课题“鱼类应对虹彩病毒感染的免疫反应与调控网络”，558万；2012-2016
五、代表性论著目录
（一）主要论文（*通讯作者）
1. Li M, Gao Z, Ji D, *Zhang S. Functional Characterization of GH-Like Homolog in AmphioxusReveals an Ancient Origin of GH/GH Receptor System. Endocrinology.2014 Dec;155(12): 4818-30.
2. Liu S, Liu Y, Yang S, HuangY, Qin Q, *Zhang S. Evolutionaryconservation of molecular structure and antiviral function of a viral receptor,LGP2, in amphioxus Branchiostomajaponicum. Eur J Immunol. 2015Dec;45(12):3404-16.
3.Gao Z, Li M, Ma J, *Zhang S. An amphioxus gC1q proteinbinds human IgG and initiates the classical pathway: Implications for aC1q-mediated complement system in the basal chordate. Eur JImmunol. 2014 Dec;44(12):3680-95.
4. Liu M, *Zhang S. AmphioxusIGF-like peptide induces mouse muscle cell development via binding to IGFreceptors and activating MAPK and PI3K/Akt signaling pathways. Mol CellEndocrinol. 2011 Aug 22;343(1-2):45-54.
5. Wang Y, *Zhang S. Identification and expression of liver-specific genesafter LPS challenge in amphioxus: the hepatic cecum as liver-like organ and pre-hepatic acute phase response. FunctIntegr Genomics. 2011 Mar;11(1):111-8.
6. Wang S, *Zhang S, ZhaoB, Lun L. Up-regulation of C/EBP by thyroid hormones: a casedemonstrating the vertebrate-like thyroid hormone signaling pathway inamphioxus. Mol Cell Endocrinol. 2009 Dec10;313(1-2):57-63.
7. Fan C, *Zhang S, Liu Z,Li L, Luan J, Saren G. Identification and expression of a novel class ofglutathione-S-transferase from amphioxus Branchiostomabelcheri with implications to the origin of vertebrate liver. Int JBiochem Cell Biol. 2007;39(2):450-61.
8. Li G, *ZhangS, Xiang J. Phenoloxidase, a marker enzyme for differentiation of theneural ectoderm and the epidermal ectoderm during embryonic development of amphioxus Branchiostoma belcheri tsingtaunese. MechDev. 2000 Aug;96(1):107-9.
9.Liu H, Lei M, Du X, Cui P, *Zhang S. Identification of a novelantimicrobial peptide from amphioxus Branchiostomajaponicum by in silico andfunctional analyses. Sci Rep. 2015 Dec 18;5:18355.
10.Wang L, Wang Y, Li Z, Gao Z, *Zhang S. Functionalcharacterization of protein 4.1 homolog in amphioxus: defining a crypticspectrin-actin-binding site. Sci Rep. 2013 Oct 7;3:2873.
11.Wang X, Du X, Li H, *Zhang S. Identification of the ZincFinger Protein ZRANB2 as a Novel Maternal Lipopolysaccharide-binding ProteinThat Protects Embryos of Zebrafish against Gram-negative Bacterial Infections. J Biol Chem. 2016 Feb 19;291(8):4019-34.
12.Wang S, Wang Y, Ma J, Ding Y, *Zhang S. Phosvitin Plays a Critical Role in the Immunity ofZebrafish Embryos via Acting as a Pattern Recognition Receptor and anAntimicrobial Effector. J Biol Chem. 2011 Jun 24;286 (25):22653-64.
13.*Zhang S, Wang S, Li H, Li L. Vitellogenin,a multivalent sensor and an antimicrobial effector. Int J Biochem Cell Biol. 2011 Mar;43(3):303-5.
14.Hu L, Sun C, Wang S, Su F, *ZhangS. Lipopolysaccharide neutralization by a novel peptidederived from phosvitin. Int J Biochem Cell Biol. 2013Nov;45(11):2622-31.
15.*Zhang S, Wang Z, Wang H. Maternalimmunity in fish. Dev Comp Immunol. 2013Jan-Feb;39(1-2):72-8
16.*Zhang S, Cui P. Complement systemin zebrafish. Dev Comp Immunol. 2014Sep;46(1):3-10.
17.Lu L, Yuan J, *Zhang S. Rejuvenating activity of salidroside (SDS): dietary intakeof SDS enhances the immune response of aged rats. Age (Dordr). 2013 Jun;35(3):637-46.
18.Wang X, Chang Q, Wang Y, SuF, *Zhang S. Late-onset temperaturereduction can retard the aging process in aged fish via a combined action of ananti-oxidant system and the insulin/insulin-like growth factor 1 signalingpathway. Rejuvenation Res. 2014Dec;17(6):507-17.
19.Yuan J, Lu L, Zhang Z, *Zhang S. Dietary intake of resveratrolenhances the adaptive immunity of aged rats. RejuvenationRes. 2012 Oct;15(5):507-15.
20.Liu C, Wang X, Feng W, Li G,Su F, *Zhang S. Differentialexpression of aging biomarkers at different life stages of the annual fishNothobranchius guentheri. Biogerontology. 2012Oct;13(5):501-10.
（二）英文专著
1.Shicui Zhang, HaimantiBhattacharya and Hongyan Li. Chapter 12Embryogenesis and Development. In “Reproductive Biology and Phylogeny ofFishes (Agnathans and Bony fishes)” (Ed. by Barrie G.M. Jamieson), 2009.Science Publishers,Plymouth.Pages 485-517.
（三）教材
张红卫（主编）、王子仁和张士璀（副主编），《发育生物学》；2001年第一版，2006年第二版，2013年第三版；高等教育出版社，北京。
六、联系方式
Email: sczhang@ouc.edu.cn
电话：0532-82032787
