张玲玲

姓名：张玲玲

学历/职称/职务：教授

联系方式：

邮箱：lingling80@ouc.edu.cn

电话：0532-82031969

地址：青岛市鱼山路5号中国海洋大学海洋生命学院

科研领域描述：

研究方向主要集中在海洋贝类功能基因组学领域，通过基因组学、转录组学、基因网络等技术，鉴别和验证扇贝性别决定、繁殖调控、免疫抗逆等相关的关键调控基因，阐明这些基因的表达调控机制。

代表性成果：（*表示通讯作者，^#表示共同第一）

Li Y, Zhang L*, Sun Y, Ma X, Wang J, Li R, Zhang M, Wang S, Hu X, Bao Z. (2016) Transcriptome sequencing and comparative analysis of ovary and testis identifies potential key sex-related genes and pathways in scallop Patinopecten yessoensis. Marine Biotechnology. 18:453-465.

Xing Q, Li Y, Guo H, Yu Q, Huang X, Wang S, Hu X, Zhang L*, Bao Z. (2016) Cardiac performance: a thermal tolerance indicator in scallops. Marine Biology. 163:244.

Sun Y, Zhang L*, Zhang M, Li R, Li Y, Hu X, Wang S, Bao Z. (2016) Characterization of three mitogen-activated protein kinases (MAPK) genes reveals involvement of ERK and JNK, not p38 in defense against bacterial infection in Yesso scallop Patinopecten yessoensis. Fish & Shellfish Immunology. 54: 507-515.

Xing Q, Yu Q, Dou H, Wang J, Li R, Ning X, Wang R*, Wang S, Zhang L*, Hu X, Bao Z. (2016) Genome-wide identification, characterization and expression analyses of two TNFRs in Yesso scallop (Patinopecten yessoensis) provide insight into the disparity of responses to bacterial infections and heat stress in bivalves. Fish & Shellfish Immunology. 52: 44-56.

Wang S^#, Lv J^#, Zhang L^#, Dou J, Sun Y, Li X, Fu X, Dou H, Mao J, Hu X & Bao Z*. (2015) MethylRAD: a simple and scalable method for genome-wide DNA methylation profiling using methylation-dependent restriction enzymes. Open Biology. 5: 150130.

Li R, Zhang R, Zhang L, Zou J, Xing Q, Dou H, Hu X, Zhang L*, Wang R*, Bao Z. (2015) Characterizations and expression analyses of NF-κB and Rel genes in the Yesso scallop (Patinopecten yessoensis) suggest specific response patterns against Gram-negative infection in bivalves. Fish & Shellfish Immunology. 44:611-21.

Fu X^#, Sun Y^#, Wang J, Xing Q, Zou J, Li R, Wang Z, Wang S, Hu X, Zhang L*, Bao Z*. (2014) Sequencing-based gene network analysis provides a core set of gene resource for understanding thermal adaptation in Zhikong scallop Chlamys farreri. Molecular Ecology Resources. 14: 184-198.

Sun Y, Zhang Y, Fu X, Zhang R, Zou J, Wang S, Hu X, Zhang L* & Bao Z. (2014) Identification of two secreted ferritin subunits involved in immune defense of Yesso scallop Patinopecten yessoensis. Fish & Shellfish Immunology. 37: 53-59.

Sun Y, Hou R, Fu X, Changsen Sun, Wang S, Wang C, Li N, Zhang L* & Bao Z. (2014) Genome-wide analysis of DNA methylation in five tissues of Zhikong scallop, Chlamys farreri. PLoS ONE. 9: e86232.

Zhang Y, Zhang R, Zou J, Hu X, Wang S, Zhang L*, Bao Z*. (2013) Identification and characterization of four ferritin subunits involved in immune defense of the Yesso scallop (Patinopecten yessoensis). Fish & Shellfish Immunology. 34: 1178-1187.

Zhang L, Hou R, Su H, Hu X, Wang S* & Bao Z*. (2012) Network analysis of oyster transcriptome revealed a cascade of cellular responses during recovery after heat shock. PLoS ONE. 7(4): e35484.

Ponomarev I*, Wang S, Zhang L, Harris RA & Mayfield RD*. (2012) Gene co-expression networks in human brain identify epigenetic modifications in alcohol dependence. Journal of Neuroscience. 32: 1884-1897.

Zhang L, Bao Z, Wang S, Hu X & Hu J*. (2008) FISH mapping and identification of Zhikong scallop (Chlamys farreri) chromosomes. Marine Biotechnology. 10: 151-157.

Zhang L, Bao Z*, Cheng J, Li H, Huang X, Wang S, Zhang C & Hu J. (2007) Fosmid library construction and initial analysis of end sequences in Zhikong scallop (Chlamys farreri). Marine Biotechnology. 9: 606-612.

Zhang L, Bao Z*, Wang S, Huang X & Hu J. (2007) Chromosome rearrangements in Pectinidae (Bivalvia: Pteriomorphia) implied based on chromosomal localization of histone H3 gene in four scallops. Genetica. 130: 193-198.