张晓华

姓名：张晓华

学历/职称/职务：博士/二级教授/博士生导师

联系方式：

邮箱：xhzhang@ouc.edu.cn电话：0532-82032767 (办公室)

地址：青岛市鱼山路5号 青岛266003 中国海洋大学海洋生命学院

工作照：

学习工作简历：

1983.09－1987.07：山东大学生物系动物学专业，获学士学位

1987.09－1990.07：山东大学生物系动物生理专业，获硕士学位

1990.08－1994.10：山东省海洋药物研究所，助理研究员

1994.10－1998.04：青岛海洋大学海洋生命学院讲师、副教授(1997.12)

1998.04－2000.11：英国赫里奥特-瓦特大学生物系微生物学专业，获博士学位

2000.12－2003.11：英国牛津大学动物学系博士后

2003.11－2004.06：英国剑桥大学遗传系博士后

2004.07－至今：中国海洋大学海洋生命学院副教授、教授(2004.12)、博士生导师(2005.12)、

三级教授（2013.1）、二级教授（2018.1）

科研领域描述：

主要研究方向为微生物海洋学，主要包括海洋微生物的生物地球化学作用、海洋细菌的密度感应及密度感应淬灭、海洋微生物的分离鉴定及资源开发等。

1. 海洋微生物的生物地球化学作用：包括海洋微生物在在海洋环境中的时空分布、环境响应以及在海洋碳循环、氮循环、硫循环中的作用等；

2. 海洋细菌的密度感应及密度感应淬灭：包括细菌密度感应对海洋颗粒有机碳降解的调控作用等；

3．海洋微生物多样性及资源开发：包括海洋微生物分离培养新技术的建立、海洋新菌的分类鉴定、海洋微生物菌种库的建立以及酶资源及有益菌的开发等。

主要研究课题：

2004.01－2006.12：主持国家自然科学基金项目“海洋弧菌中溶血素的研究”（30371119），经费20万元。

2005.01－2007.12：入选2004年教育部新世纪优秀人才支持计划（NCET-04-0645），经费50万元。

2007.12－2010.12：主持国家863计划项目“中国黄海微生物资源采集、保存和信息化技术”（2007AA09Z434），经费100万元。

2008.01－2010.12：主持国家自然科学基金项目“哈维氏弧菌VHH溶血素作用机理的研究”（30771656），经费32万元。

2008.01－2009.12：主持教育部科学技术研究重点项目“致病性哈维氏弧菌毒性相关质粒的研究”（108082），经费10万元。

2009.01－2011.12：主持国家自然科学基金项目“海洋拮抗菌假交替单胞菌JG1作用机理的研究”（40876067），经费44万元。

2009.01－2011.12：主持国家自然科学基金委与香港研究资助局（NSFC-RGC）联合科研基金项目“弧菌毒力因子对鱼类细胞保护和细胞调亡的作用研究” (30831160512)，内地经费31.5万元。

2008.12－2012.12：国家 863计划重点项目“迟钝爱德华氏菌毒力相关功能基因研究及疫苗开发”（2008AA092501），参与，个人经费84万元。

2012.01－2015.12：国家 863计划重点项目“深海微生物分离培养与基因资源获取技术研究”（2012AA092103）子课题“深海微生物高通量分离培养技术及装置研发”，主持，经费190万元。

2012.07－2014.06：主持科技部国际科技合作重点项目“利用密度感应抑制技术控制水产养殖细菌性病害的合作研究”（2012DFG31990），经费100万元。

2013.01－2016.12：主持国家自然科学基金项目“南太平洋环流区洋底沉积物及海水的微生物群落演化及功能活性研究”（41276141），经费87万元。

2013.01－2018.12：国家自然科学基金创新群体项目“海洋有机生物地球化学”（41221004 &延续41521064），参加，个人经费34万元。

2013.01－2015.09：中国大洋协会国际海域资源调查与开发“十二五”项目“深海结核、结壳区微生物多样性与资源潜力评价”（DY125-15-R-03），参加，个人经费104万元。

2015.01－2018.12：主持国家自然科学基金项目“我国边缘海颗粒有机碳中细菌密度感应及其对有机碳降解的调控作用”（41476112），经费100万元。

2016.06－2021.05：国家重点研发计划“全球变化及应对”重点专项“中国东部陆架海域生源活性气体的生物地球化学过程及气候效应”项目课题3“微生物在海洋生源活性气体循环中的作用与机制”（2016YFA0601303）。个人经费120万。

2018.01－2022.12：主持国家自然科学基金重点项目“弧菌在我国边缘海的生态分布及在碳循环中的作用研究”（41730530）。经费376.4万元（直接经费315万元）。

2018.01－2021.12：主持国家自然科学基金委“水圈微生物驱动地球元素循环的机制”重大研究计划重点支持项目“海洋异养细菌对DMSP/DMS产生的贡献及驱动硫循环的机制：以马里亚纳海沟为例”（91751202）。经费382.3万元（直接经费320万元）。

2018.01－2020.12：青岛海洋科学与技术试点国家实验室山东省海洋科技资金重大科技专项“蓝色药库”技术创新工程项目“海洋药源生物基础研究”课题 6-4海洋细菌多样性、分子生态学及功能解析 (2018SDKJ0406-4)，参加。经费60万元。

2018.05－2018.11：广州海洋地质调查局地质调查项目“试采海底孔隙压力监测与海洋物理环境研究”(2018C-03-186)，参加。经费32.2万元。

2019.07-2019.08：科技部国际合作司发展中国家技术培训班“海洋微生物学技术国际培训班”（20190176）。经费：30.5648万元。

2020.01－2022.12：主持国家重点研发计划政府间国际科技创新合作重点专项“以弧菌作为生物感应器指示全球/区域变化的研究”(2018YFE0124100)。经费288万元。

获奖情况及荣誉称号：

1. 入选2004年教育部“新世纪优秀人才支持计划”。

2. 获2010年国家海洋局海洋创新成果二等奖（第1位），获奖题目：哈维氏弧菌溶血素的发现与致病机理。

3. 获2014年国家海洋局海洋科学技术二等奖（第1位），获奖题目：海洋微生物培养新技术的建立及菌种库建设。

4. 获2014年青岛市自然科学二等奖（第1位），获奖题目：海水鱼类主要病原菌的致病性及其环境适应机制。

5．获 2014、2016、2017和2019年山东省优秀硕士/博士学位论文指导教师。

代表性论文

1. Liu J, Zheng Y, Lin H, Wang X, Li M, Liu Y, Yu M, Zhao M, Pedentchouk N, Lea-Smith DJ, Todd JD, Magill CR, Zhang W-J, Zhou S, Song D, Zhong H, Xin Y, Yu M, Tian J*, Zhang X-H*. Proliferation of hydrocarbon degrading microbes at the bottom of the Mariana Trench. Microbiome, 2019, 7: 47.（SCI, IF2018: 10.465；被引用6次）

2. Williams BT, Cowles K, Martínez AB, Curson ARJ, Zheng Y, Liu J, Newton-Payne S, Hind A, Li C-Y, Rivera PPL, Carrión O, Liu J, Spurgin LG, Brearley CA, Mackenzie BW, Pinchbeck BJ, Pratscher J, Zhang X-H, Zhang Y-Z, Murrell JC, Todd JD. Bacteria are important dimethylsulfoniopropionate producers in coastal sediments. Nat Microbiol, 2019, 4:1815–1825. (SCI, IF2017: 14.174；被引用1次)

3. Liang J, Liu J, Wang X, Lin H, Liu J, Zhou S, Sun H, and Zhang X-H*. Spatiotemporal dynamics of free-living and particle-associated Vibrio communities in the northern Chinese marginal seas. Appl Environ Microbiol,  2019, 85:e00217-19.（SCI, IF2018: 4.077；被引用3次）

4. Wang X, Liu J, Li B, Liang J, Sun H, Zhou S, and Zhang X-H*. Spatial heterogeneity of Vibrio spp. in sediments of Chinese marginal seas. Appl Environ Microbiol, 2019, 85:e03064-18.（SCI, IF2018: 4.077；被引用2次）

5. Xu T, Yu M, Liu J, Lin H, Liang J, and Zhang X-H*. Role of RpoN from Labrenzia aggregate LZB033 (Rhodobacteraceae) in formation of flagella and biofilms, motility, and environmental adaptation. Appl Environ Microbiol, 2019, 85:e02844-18.（SCI, IF2018: 4.077）

6. Zhang X-H*, Liu J, Liu J, Yang G-P, Xue C, Curson ARJ, Todd JD. Biogenic production of DMSP and its degradation to DMS– their roles in global sulfur cycle. Sci China Life Sci, 2019, 62, 1296–1319.（SCI, IF2018: 3.583；被引用1次）

7. Su Y, Tang K, Liu J, Wang Y, Zheng Y, and Zhang X-H*. Quorum sensing system of Ruegeria mobilis Rm01 controls lipase and biofilm formation. Front Microbiol, 2019, 9:3304. (SCI, IF2018: 4.259)

8. Liu J, Xue C-X, Sun H, Zheng Y, Meng Z, Zhang X-H*. Carbohydrate catabolic capability of a Flavobacteriia bacterium isolated from hadal water. Syst Appl Microbiol, 2019, 42, 263-274.（SCI, IF2018: 2.808；被引用1次）

9. Zhang X-H*, Lin H, Wang X, Austin B. Significance of Vibrio species in the marine organic carbon cycle – a review. Sci China Earth Sci, 2018, 61(10): 1357-1368. (SCI, IF2018: 2.258；封面文章；被引用10次)

10. Liu J, Liu J, Zhang S-H, Liang J, Lin H, Song D, Yang G-P, Todd JD*, Zhang X-H*. Novel insights into bacterial dimethylsulfoniopropionate catabolism in the East China Sea. Front Microbiol, 2018, 9: 3206. (SCI, IF2018: 4.259；被引用2次)

11. Lin H, Yu M, Wang X, and Zhang X-H*. Comparative genomic analysis reveals the evolution and environmental adaptation strategies of vibrios. BMC Genomics, 2018, 19:135. (SCI, IF2017:3.730；被引用8次)

12. Wang L, Yu M, Liu Y, Liu J, Wu Y, Li L, Liu J, Wang M and Zhang X-H*.  Comparative analyses of the bacterial community of hydrothermal deposits and seafloor sediments across Okinawa Trough. J Mar Sys, 2018, 180: 162-172. (SCI, IF2017: 2.506；被引用2次)

13. Curson A, Liu J, Martinez AB, Green R, Chan Y, Carrion O, Williams B, Zhang S-H, Yang G-P, Page PB, Zhang X-H* & Todd J*. 2017. Dimethylsulphoniopropionate biosynthesis in marine bacteria and identification of the key gene in this process. Nat Microbiol, 2017, 2: e17009. (SCI, IF2017: 14.174；被引用65次)

14. Zheng Y, Yu Min, Liu J, Qiao Y, Wang L, Li Z, Zhang X-H* and Yu M*. Bacterial community associated with healthy and diseased Pacific white shrimp (Litopenaeus vannamei) larvae and rearing water across different growth stages. Front Microbiol, 2017, 8:1362. (SCI, IF2017: 4.019，被引用17次)

15. Gao M, Liu J, Qiao Y, Zhao M, Zhang X-H*. 2017. Diversity and abundance of the denitrifying-microbiota in the sediment of eastern China marginal seas and the impact of environmental factors. Microb Ecol, 73, 602–615. (SCI, IF2017: 3.614；被引用8次)

16. Yu S, Yao P, Liu J, Zhao B, Zhang G, Zhao M, Yu Z and Zhang X-H*. 2016. Diversity, abundance, and niche differentiation of ammonia-oxidizing prokaryotes in mud deposits of the eastern China marginal seas. Front Microbiol, 7:137. (SCI, IF2016: 4.165；被引用17次)

17. Wang Y, Song Q, Zhang X-H*. Marine microbiological enzymes: studies with multiple strategies and prospects. Mar Drugs, 14(10), 171. (SCI, IF2015: 3.345；被引用4次)

18. D'Hondt S, Inagaki F, Zarikian C, Abrams L, Dubois N, Engelhardt T, Evans H, Ferdelman T, Gribsholt B, Harris R, Hoppie B, Hyun J-H, Kallmeyer J, Kim J, Lynch J, McKinley C, Mitsunobu S, Morono Y, Murray R, Pockalny R, Sauvage J, Shimono T, Shiraishi F, Smith D, Smith-Duque C, Spivack A, Steinsbu B, Suzuki Y, Szpak M, Toffin L, Uramoto G, Yamaguchi Y, Zhang G-L, Zhang X-H, and Ziebis W. 2015. Presence of oxygen and aerobic communities from seafloor to basement in deep-sea sediment. Nature Geoscience, 8(4), 299-304. (SCI, IF2015: 12.508；被引用105次)

19. Tang K, Su Y, Brackman G, Cui F, Zhang Y, Shi X, Coenye T, Zhang X-H*. 2015. MomL, a novel marine-derived N-acyl homoserine lactonase from Muricauda olearia. Appl Environ Microbiol, 81:774 –782. (SCI, IF2015: 3.823；被引用49次)

20. Zhang Y, Liu J, Tang K, Yu M, Coenye T, Zhang X-H*. 2015. Genome analysis of Flaviramulus ichthyoenteri Th78T in the family Flavobacteriaceae: insights into its quorum quenching property and potential roles in fish intestine. BMC Genomics, 16:38. (SCI, IF2015: 3.867；被引用14次)

21. Liu J, Fu B, Yang H, Zhao M, He B, Zhang X-H*. 2015. Phylogenetic shifts of bacterioplankton community composition along the Pearl Estuary: the potential impact of hypoxia and nutrients. Front Microbiol, 6, 64. (SCI, IF2015: 4.165；被引用58次)

22. Fu B, Liu J, Yang H, Hsu TC, He B, Dai M, Kao SJ, Zhao M, Zhang X-H*. 2015. Shift of anammox bacterial community structure along the Pearl Estuary and the impact of environmental factors. J Geophys Res – Oceans, 120, 2869–2883. (SCI, IF2015: 3.318；被引用23次)

23. Liu J, Liu X, Wang M, Qiao Y, Zheng Y, Zhang X-H*. 2015. Bacterial and archaeal communities in sediments of the north Chinese marginal seas. Microb Ecol, 70, 105-117. (SCI, IF2015: 3.232；被引用53次)

24. Jatt AN, Tang K, Liu J, Zhang Z, Zhang X-H*. 2015. Quorum sensing in marine snow and its possible influence on production of extracellular hydrolytic enzymes in marine snow bacterium Pantoea ananatis B9. FEMS Microbiol Ecol, 91, 1-13. (SCI, IF2015: 3.53；被引用31次)

25. Xu T, Yu  M, Lin  H, Zhang  Z, Liu  J, Zhang  X-H*. 2015. Genomic insight into Aquimarina longa SW024T: its ultra-oligotrophic adapting mechanisms and biogeochemical functions. BMC Genomics, 16:772. (SCI, IF2015: 3.867；被引用4次)

26. Zhang L, Wang X, Yu M, Qiao Y, Zhang X-H*. 2015. Genomic analysis of Luteimonas abyssi XH031T: insights into its adaption to the subseafloor environment of South Pacific Gyre and ecological role in biogeochemical cycle. BMC Genomics, 16:1092. (SCI, IF2015: 3.867；被引用10次)

27. Liu J, Yu S, Zhao M, He B, Zhang X-H*. 2014. Shifts in archaeaplankton community structure along ecological gradients of Pearl Estuary. FEMS Microbiol Ecol, 90, 424-435. (SCI, IF2013: 3.875；被引用20次)

28. Tang K, Zhang X-H*. 2014. Quorum quenching agents: resources for antivirulence therapy. Mar Drugs, 12, 3245-3282. (SCI, IF2013: 3.512；被引用84次)

29. Liu J, Yang H, Zhao M, Zhang X-H*. 2014. Spatial distribution patterns of benthic microbial communities along Pearl Estuary. Syst Appl Microbiol. 37, 578-589. (SCI, IF2013: 3.366；被引用40次)

30. Cui F, Dong S, Shi X*, Zhao X, Zhang X-H. 2014. Overexpression and characterization of a novel thermostable β-agarase YM01-3, from marine bacterium Catenovulum agarivorans YM01^T. Mar Drugs, 12, 2731-2747. (SCI, IF2013: 3.512；被引用36次)

31. Yuan M, Yu Y, Li H-R, Dong N, Zhang X-H. 2014. Phylogenetic diversity and biological activity of actinobacteria isolated from marine sediments of the Chukchi Shelf, arctic ocean. Marine Drugs, 12, 1281-1297. (SCI, IF2013: 3.512；被引用61次)

32. Tang K, Zhang Y, Yu M, Shi X, Coenye T, Bossier P, Zhang X-H*. 2013. Evaluation of a new high-throughput method for identifying quorum quenching bacteria. Sci Rep, 3, 2935. (SCI, IF2013: 5.078；被引用40次)

33. Yu M, Tang K, Liu J, Shi X, Gulder TAM, Zhang X-H*. 2013. Genome analysis of Pseudoalteromonas flavipulchra JG1 reveals various survival advantages in marine environment. BMC Genomics 14:707. (SCI, IF2012: 4.397；被引用19次)

34. Yin Q, Fu B, Li B, Shi X, Inagaki F and Zhang X-H*. 2013. Spatial variations in microbial community composition in surface seawater from the ultra-oligotrophic center to rim of the South Pacific Gyre. PLOS ONE 8(2), e55148. (SCI, IF2012: 3.73；被引用54次)

35. Wang B, Yu T, Dong X, Zhang Z, Song L, Xu Y, Zhang X-H*. 2013. Edwardsiella tarda invasion of fish cell lines and the activation of divergent cell death pathways. Vet Microbiol, 163, 282-289 (SCI, IF2011: 3.127；被引用17次)

36. He Y, Xu T, Fossheim LE, Zhang X-H*. 2012. FliC, a flagellin protein, is essential for the growth and virulence of fish pathogen Edwardsiella tarda.  PLoS One, 7(9): e45070. (SCI, IF2011: 4.092；被引用41次)

37. Yu M, Wang J, Tang K, Shi X, Wang S, Zhu W-M* and Zhang X-H*. 2012. Purification and characterization of antibacterial compounds of Pseudoalteromonas flavipulchra JG1. Microbiology (SGM), 158, 835 – 842. (SCI, IF2011: 3.061；被引用35次)

38. Han Y, Yang C-L, Yang Q, Qi Z, Liu W, Xu Z-H, Zhu W-M*, Bossier P & Zhang X-H*. 2011. Mutation of tryptophanase gene tnaA in Edwardsiella tarda reduces lipopolysaccharide production, antibiotic resistance and virulence. Environ Microbiol Rep, 3, 603-612. (SCI, IF2011: 3.232；被引用13次)

39. Bai F, Sun B, Woo NYS & Zhang X-H*. 2010. Vibrio harveyi hemolysin induces ultrastructural changes and apoptosis in flounder (Paralichthys olivaceus) cells. Biochem Biophys Res Commun, 395, 70-75. (SCI, IF2010: 2.595；被引用13次)

40. Jia A & Zhang X-H*. 2009. Molecular cloning, characterization and expression analysis of cathepsin D gene from turbot Scophthalmus maximus. Fish Shellfish Immunol, 26, 606-613. (SCI, IF2008: 3.16；被引用48次)

41. Yang H, Chen J, Yang G, Zhang X-H. 2009. Protection of Japanese flounder (Paralichthys olivaceus) against Vibrio anguillarum with a DNA vaccine containing the mutated zinc-metalloprotease gene. Vaccine, 27, 2150–2155. (SCI, IF2008: 3.298；被引用25次)

42. Sun F, Chen J, Zhong L, Zhang X-H, Wang R, Guo Q & Dong Y. 2008. Characterization and virulence retention of viable but nonculturable Vibrio harveyi.  FEMS Microbiol Ecol, 64, 37-44. (SCI, IF2007: 3.039；被引用54次)

43. Sun B, Zhang X-H*, Tang X, Wang S, Zhong Y, Chen J & Austin B. 2007.  A particular single residue change in Vibrio harveyi hemolysin (VHH) results in the loss of phospholipase and hemolytic activities and pathogenicity to turbot (Scophthalmus maximus).  J Bacteriol, 189, 2575-2579. (SCI, IF2007: 4.013；被引用38次)

44. Du M, Chen J, Zhang X-H, Li A, Li Y & Wang Y. 2007. Retention of virulence in a viable-but-nonculturable Edwardsiella tarda isolate. Appl Environ Microbiol, 73, 1349-1354. (SCI, IF2007: 4.004；被引用96次)

45. Zhong Y, Zhang X-H*, Chen J, Chi Z, Sun B, Li Y & Austin B. 2006. Overexpression, purification, characterization and pathogenicitiy of Vibrio harveyi hemolysin VHH.  Infect Immun, 74, 6001-6005. (SCI, IF2006: 4.004；被引用53次)

46. Zhang X-H, Axton JM, Drinjákovic J, Lorenz L, White-Cooper H & Renault AD. 2004.  Spatial and temporal control of mitotic cyclins by the Gnuregulator of embryonic mitosis in Drosophila. J Cell Sci, 117, 3571-3578. (SCI, IF2004: 7.250)

47. Renault AD, Zhang X-H, Alphey LS, Frenz LM, Glover DM, Saunders RDC & Axton JM. 2003.  giant nuclei is essential in the cell cycle transition from meiosis to mitosis.   Development, 130, 2997-3005. (SCI, IF2004: 7.149)

48. Zhang X-H, Meaden PG. & Austin B. 2001.  Duplication of hemolysin genes in a virulent isolate of Vibrio harveyi.  Appl Environ Microbiol, 67, 3161-3167. (SCI, IF2004: 3.810；被引用122次)

Name:Xiao-Hua Zhang

Title: professor in Marine Microbiology

Contact

Email：xhzhang@ouc.edu.cn              Tel：0086-532-82032767 (office)

Address：

Colleage of Marine Life Sciences

Ocean University of China

Yushan 5 Road, Qingdao 266003, China

Photo

Experiences:

Education

Employment and experience

Teaching

Teaching Microbiology, Marine Microbiology and Modern Microbiological Methods

Research Interests

Microbial oceanography (including roles of marine microorganisms in driving biogeochemical cycles; bacterial quorum sensing and quorum quenching; marine bacterial taxonomy and  applications)