董波

发布者:杨光发布时间:2022-06-29浏览次数:19691

董波,博士,教授

海洋生物遗传学与育种教育部重点实验室副主任

山东省泰山学者特聘专家

中国海洋大学筑峰工程特聘教授

E-mail: bodong@ouc.edu.cn

Tel: 0532-82032732

https://www.researchgate.net/profile/Bo_Dong4


教育及工作背景:1997年毕业于青岛海洋大学,2005年在中国科学院海洋研究所获博士学位,2006-2010年在挪威卑尔根大学萨斯国际海洋分子生物学中心做博士后, 2010-2014年受聘任日本理化学研究所神户发育生物学中心国际特别研究员。2014年至今任中国海洋大学“筑峰计划”特聘教授、青岛市创新创业领军人才、山东省“泰山学者”特聘教授、山东省有突出贡献中青年专家。现任中国海洋湖沼学会理事,《Marine Life Science & Technology》和《中国海洋大学学报》(自然科学版)等期刊编委。主持科技部重点研发计划政府间重点专项、国家基金和山东省重大研发等多个项目。


主要研究方向及成果:

 主要从事动物遗传发育生物学研究,以进化节点动物海鞘和模式动物果蝇为实验材料,通过遗传学、细胞发育生物学和生物物理学等多学科交叉途径,研究囊泡极性运输、细胞骨架动态、胞外基质物理特性及其对细胞行为的影响等。在器官发育和稳态维持机制等方面取得重要进展,发现了脊索管腔形成的细胞学过程,揭示了调控细胞及器官形态发育变化的重要信号通路,建立了决定生物管腔几何形状的数学物理模型。研究成果发表在PNAS, PLoS Biology, eLife, Nature CommunicationsCell ReportsDevelopmentFASEB J等领域主流刊物。


主持项目:


  • 国家重点研发计划政府间国际科技创新合作重点专项:细胞外基质在管腔器官形态发生与稳态维持中的角色和功能研究 (2020-2022)  

  • 国家基金面上项目:真海鞘肠道微生物组学解析及活性成分功能鉴定 (2020-2023)

  • 国家基金面上项目:软骨调节素在海鞘脊索腔液形成中的分子调控机制 (2018-2021)

  • 国家基金面上项目:小窝蛋白在海洋模式动物海鞘脊索发育中的角色 (2016-2019)

  • 山东省重大科技创新工程专项课题:海洋动物个体发育与系统演化遗传基础 (2018-2020)



 实验室目前有硕士、博士及博士后位置开放,并欢迎客座研究科学家交流合作。如果您对实验室研究领域和方向感兴趣,并具有发育生物学、细胞生物学或生物物理学等背景,欢迎来信询问。


Prof. Dr. Bo DONG:

2014.9-: Professor, Ocean University of China, Qingdao, China;

2013.11- 2014. 9: Research Scientist, RIKEN Center for Developmental Biology (CDB), Kobe, Japan;

2010.11- 2013.10: Foreign Postdoctoral Researcher, RIKEN CDB;

2006.10- 2010.10: Postdoctoral fellow, Sars International Centre for Marine Molecular Biology, Bergen, Norway;

2001.7- 2005.7: Ph.D., Institute of Oceanology, Chinese Academy of Sciences (IOCAS), Qingdao, China.

Research Interests: Our group is principally interested in uncovering cellular processes and the underlying mechanisms that support the biological tube formation and tail regression during embryogenesis. We use marine animal (Ciona) notochord and Drosophila tracheal system as models to understand the morphogenetic signaling network on polarized vesicle trafficking, cytoskeletal organization, membrane biogenesis, and extracellular matrix dynamics during lumen formation and cell shape change.


Job and Contact: We are always looking for people with experience and interests in developmental biology, Cell biology, or biophysics to join us. If you are interested in working with us as a graduate student, postdoc or visiting scientist, please contact us for possible openings.


Laboratory for Morphogenesis & Evolution

Sars-Fang centre, Ocean University of China

No.5 Yushan Road, 266003, Qingdao, China

Tel: 0532-82032732

E-mail:bodong@ouc.edu.cn

代表性文章 *通讯作者,#共同第一作者

1. Fu Y.#, Lv Z.#, Kong D., Fan Y., Dong B*, High abundance of CDC45 inhibits cell proliferation through elevation of HSPA6. Cell proliferation. 2022, e13257. doi:10.1111/cpr.13257.

2. Sun X, Zhang X, Yang L, Dong B*, A microRNA cluster-Lefty pathway is required for cellulose synthesis during ascidian larval metamorphosis. Frontiers in Cell and Developmental Biology. 2022, 10:835906. doi: 10.3389/fcell.2022.835906.

3. Zhao L#, Gao F#, Gao S#, Liang Y#, Long H#, Lv Z#, Su Y#, Ye N#, Zhang L#, Zhao C#, Wang X, Song W*, Zhang S*, Dong B*, Biodiversity-based development and evolution: The emerging research systems in model and non-model organisms. Science China Life Sciences. 2021, 64(8):1236-1280. https://doi.org/10.1007/s11427-020-1915-y.

4..Peng H, Qiao R, Dong B*, Polarity establishment and maintenance in ascidian notochord. Frontiers in Cell and Developmental Biology. 2020, 8: 597446. doi: 10.3389/fcell.2020.597446.

5.Lu Q#, Gao Y#, Fu Y, Peng H, Shi W, Li B, Lv Z, Feng X, Dong B*, Ciona embryonic tail bending is driven by asymmetrical notochord contractility and coordinated by epithelial proliferation. Development. 2020. 147. doi:10.1242/dev.185868. (当期亮点文章,被选为最令人兴奋科研发现进行作者采访和推荐报道)

6.Wei J, Zhang J, Lu Q, Ren P, Guo X, Wang J, Li X, Chang Y, Duan S, Wang S, Yu H, Zhang X, Yang X, Gao H, Dong B*, Genomic basis of environmental adaptation in the leathery sea squirt (Styela clava). Molecular Ecology Resources. 2020. 20:1414-1431. (被选为当月唯一亮点文章,并进行了作者采访和推荐报道)

7.Wei J, Gao H, Yang Y, Liu H, Yu H, Chen Z*, Dong B*, Seasonal dynamics and starvation Impact on the gut microbiome of urochordate ascidian Halocynthia roretz. Animal Microbiome, 2020, 2: 30. https://doi.org/10.1186/s42523-020-00048-2.

8.Bhattachan P., Rae J, Yu H, Jung W., Wei J.,Parton R. G*., and Dong B*, Ascidian caveolin induces membrane curvature and protects tissue integrity and morphology during embryogenesis. The FASEB Journal, 2020, 34 (1): 1345-1361.

9.Lv Z, Lu Q, Dong B*, Morphogenesis: a focus on marine invertebrates. Marine Life Science & Technology, 2019, 1: 28-40.

10.Lu Q, Bhattachan P, Dong B*. Ascidian notochord elongation, Developmental Biology. 2019, 448147-153.

11.Zhang X, Liu X, Liu C, Wei J, Yu H, Dong B*. Identification and characterization of microRNAs involved in ascidian larval metamorphosis. BMC Genomics. 2018, 19(1):168

12.Wei J, Wang G, Li X, Ren P, Yu H, Dong B*. 2017. Architectural delineation and molecular identification of extracellular matrix in ascidian embryos and larvae. Biology Open 6(9): 1383-1390. (封面文章)

13.董波*。海洋模式动物海鞘及其脊索发育与调控科学通报201560: 1167-1179.

14.Sehring I, Recho P, Denker E, Kourakis M, Mathiesen B, Hannezo E*, Dong B*, Jiang D*. 2015. Assembly and positioning of actomyosin rings by contractility and planar cell polarity.eLife 4: e09206. (当期亮点文章,faculty of 1000专家推荐)

15.Hannezo E#, *, Dong B#, *, Recho P, Joanny JF, Hayashi S. 2015. A cortical instability drives periodic supracellular actin pattern formation in epithelial tubes. PNAS 112 (28): 8620-8625. (PNAS同期配发了点评文章)

16.Dong B, Hayashi S*. Shaping of biological tubes by mechanical interaction of cell and extracellular matrix. Current Opinion in Genetics & Development, 2015, 32: 129-134. (邀请综述文章)

17Sehring I#,Dong B#,Denker E,Bhattachan P,Deng W, Mathiesen B, Jiang D*. An equatorial contractile mechanism drives cell elongation but not cell division. PLoS Biology, 2014,12(2): e1001781. (同期配发了点评文章,faculty of 1000专家推荐)

18.Dong B*, Hannezo E, Hayashi S*. 2014. Balance between apical membrane growth and luminal matrix resistance determines the shape of epithelial tubule. Cell Reports 7(4): 941-950.

19.Dong B, Miao GX, Hayashi S*. A fat body-derived apical extracellular matrix enzyme is transported to the tracheal lumen and is required for tube morphogenesis in Drosophila. Development, 2014 141 (21): 4104-4109. (当期亮点文章)

20.DongB, KakiharaK, Otani T, WadaH, Hayashi S*. 2013. Rab9 and retromer regulate retrograde trafficking of luminal protein required for epithelial tube length control. Nature Communications 4, 1358.

21.Dong B, Deng W, Jiang D*, Distinct cytoskeleton populations and extensive crosstalk control Ciona notochord tubulogenesis. Development, 2011, 138 (8): 1631-1641.(faculty of 1000专家推荐)

22.Dong B, Horie T, Denker E, Kusakabe T, Tsuda M, Smith WC, Jiang D*.  Tube formation by complex cellular processes in Ciona intestinalis notochord. Developmental Biology, 2009. 330: 237-249.