刘雅

发布者:杨光发布时间:2022-03-07浏览次数:15110

 

 

姓名:刘雅

学历/职称/职务:博士/副教授/硕士生导师

邮箱:yaliu @ouc.edu.cn

地址:山东省青岛市鱼山路5号中国海洋大学科学馆210

科研领域:生物医用材料的研发与组装调控,主要包括:纳米技术、药物递送、肿瘤治疗、组织工程、过度免疫治疗等。

学习工作简历:

20161月至今:中国海洋大学 海洋生命学院 副教授

20144月—201512月: 中国海洋大学 海洋生命学院 讲师

20128月—20141月:国家纳米科学中心  联合培养

20089月—20136月:中国海洋大学 海洋生命学院 海洋生物学专业 博士

20049月—20086月:中国海洋大学 海洋生命学院 生物技术专业 学士

科研领域:

主持国家自然科学基金、山东省自然科学基金、中国博士后基金特别资助、中国博士后科学面上基金、青岛市自主创新应用专项、青年教师专项基金等;获得山东省自然科学学术创新奖、山东省优秀博士学位论文、山东省研究生优秀科技创新成果奖、中国海洋大学第十四届优秀博士学位论文一等奖等多项学术奖励。

代表性成果

一.发表论文:

1. Ya Liu , Di Zhang , Zeng-Ying Qiao , Guo-Bin Qi , Xing-Jie Liang , Xi-Guang Chen*, Hao Wang*. A Peptide-Network Weaved Nanoplatform with Tumor Microenvironment Responsiveness and Deep Tissue Penetration Capability for Cancer Therapy. Advanced Materials27 (2015) 5034–5042 (IF: 30.849)

2. Ya Liu, Li-Li Li, Guo-Bin Qi, Yun-Shan Fan, Xi-Guang Chen*, Hao Wang*. Dynamic Disordering of Co-Assemblied Liposomal Cocktails: Spatio-Temporal Controlled Release of Cargoes to Circumvent Drug Resistance. Biomaterials 35 (2014) 3406-3415. (IF: 12.479)

3. Ya Liu, Fu-Ping Gao, Di Zhang, Yun-Shan Fan, Xi-Guang Chen*, Hao Wang*. Molecular Structural Transformation Regulated Dynamic Disordering of Supramolecular Vesicles as pH-Responsive Drug Release Systems. Journal of Controlled Release 173 (2014) 140–147. (IF: 9.776)

4. Ya Liu, Xiguang Chen*, Hao Wang, Nanoplatform containing MMPs-sensitive peptide-PEG conjugate and tissue-penetrating moiety for enhanced cancer therapy. Journal of Controlled Release DOI: 10.1016/j.jconrel.2017.03.324. (IF: 9.776)

5. Ya Liu* Pei-Pei Yang, Zeng-Ying Qiao, Hao Wang and Xi-Guang Chen*. Tumor Microenvironmental pH and Enzyme Dual Responsive Polymer-Liposomes for Synergistic Treatment of Cancer Immuno-Chemotherapy.Biomacromolecules 2019, 20, 882−892. (IF: 6.988)

6. Ya Liu*, Fang-Qin Wang, Zeana Shah, Xiao-Jie Cheng, Ming Kong, Chao Feng, Xi-Guang Chen*. Nano-polyplex based on oleoyl-carboxymethy-chitosan (OCMCS) andhyaluronic acid for oral gene vaccine delivery. Colloids and Surfaces B: Biointerfaces145 (2016) 492–501. (IF: 5.268)

7. Ya Liu, Ming Kong, Xiao Jie Cheng, Qian Qian Wang, Li Ming Jiang, Xi Guang Chen*. Self-assembled nanoparticles based on amphiphilic chitosan derivative and hyaluronic acid for gene delivery. Carbohydrate Polymers 94 (2013) 309-316. (IF: 9.381)

8. Ya Liu, Ming Kong, Kui Kun Yang, Yang Li, Jing Su, Xiao Jie Cheng, Hyun Jin Park*, Xi Guang Chen*. Biocompatibility, cellular uptake and biodistribution of the polymeric amphiphilic nanoparticles as oral drug carriers. Colloids and Surfaces B: Biointerfaces 103 (2013) 345-353. (IF: 5.268)

9. Ya Liu, Hui Di Zang, Ming Kong, Fang Kui Ma, Qi Feng Dang, Xiao Jie Cheng*, Qiu Xia Ji, Xi Guang Chen*. In vitro evaluation of mucoadhesion and permeation enhancement of polymeric amphiphilic nanoparticles. Carbohydrate Polymers 89 (2012) 453–460. (IF: 9.381)

10. Ya Liu, Xiao Jie Cheng, Qi Feng Dang, Fang Kui Ma, Xi Guang Chen*, Hyun Jin Park, Bum Keun Kim. Preparation and evaluation of Oleoyl-carboxymethy-chitosan (OCMCS) nanoparticles as oral protein carriers. Journal of Material Science: Material in Medicine. 23(2012) 375–384. (IF: 3.896)

11. Ya Liu, Mengjie Sun, Ting Wang, Xiguang Chen, Hao Wang. Chitosan-based self-assembled nanomaterials: Theirapplication in drug delivery. VIEW.2020; 20200069

12Ying-Hua Guan, Na Wang, Zhen-Wei Deng, Xi-Guang Chen, Ya Liu*. Exploiting autophagy-regulative nanomaterials for activation of dendritic cells enables reinforced cancer immunotherapy. Biomaterials 282 (2022) 121434 (IF: 12.479)

13.Di Qin#, Andi Zhang#, Na Wang, Yingxia Yao, Xiguang Chen, Ya Liu*. Hydroxybutyl chitosan/ oxidized glucomannan self-healing hydrogels as BMSCs-derived exosomes carriers for advanced stretchable wounds. Applied Materials Today 26 (2022) 101342.(IF: 10.041)

14. Ting Wang#, Zheng He#, Cong-Shan Yuan, Zhen-Wei Deng, Fang Li, Xi-Guang Chen, Ya Liu*. MMP-responsive transformation nanomaterials with IAP antagonist to boost immune checkpoint therapy. Journal of Controlled Release 343 (2022) 765-776.(IF: 9.776)

15.Meng-jie Sun#, Zhuang Teng#, Peng-sheng Fan, Xi-guang Chen, Ya Liu*. Bridging micro/nano-platform and airway allergy intervention. Journal of Controlled Release 341 (2022) 364-382. (IF: 9.776)

16. Di Qin#, Na Wang#, Xin-Guo You, An-Di Zhang, Xi-Guang Chen*, Ya Liu*. Collagen-based biocomposites inspired by bone hierarchical structures for advanced bone regeneration: ongoing research and perspectives. Biomaterials Science 2022, 10, 318-353. (IF: 6.843)

17. Zhen-Wei Deng, Cong-Shan Yuan, Ting Wang, Xi-Guang Chen, Ya Liu*. Peptide-based assemblies as immune checkpoint inhibitor delivery systems for enhanced immunotherapy. Applied Materials Today23 (2021) 101063. (IF: 10.041)

18. Mengjie Sun#, Di Qin#, Pengsheng Fan, Xiguang Chen, Ya Liu*. Chitosan-centered nanosystems as sustained therapeutics for allergic rhinitis intervention: Inhibition of histamine-induced cascades. Journal of Controlled Release335 (2021) 422-436.(IF: 9.776)

19. Mei-Ping Tian, An-Di Zhang, Ying-Xia Yao, Xi-Guang Chen, Ya Liu*. Mussel-inspired adhesive and polypeptide-based antibacterial thermo-sensitive hydroxybutyl chitosan hydrogel as BMSCs 3D culture matrix for wound healing. Carbohydrate Polymers 261 (2021) 117878. (IF: 9.381)

20. Cong-Shan Yuan, Zhen-Wei Deng, Di Qin, Yu-Zhi Mu, Xi-Guang Chen, Ya Liu*. Hypoxia-modulatory nanomaterials to relieve tumor hypoxic microenvironment and enhance immunotherapy: Where do we stand? Acta Biomaterialia 125 (2021) 1–28. (IF: 8.516)

21. Yingxia Yao, Andi Zhang, Congshan Yuan, Xiguang Chen, Ya Liu*. Recent trends on burn wound care: hydrogel dressings and scaffolds. Biomaterials Science 2021, 9, 4523. (IF: 6.843)

22. Peng-Sheng Fan#, Meng-Jie Sun#, Di Qin, Cong-Shan Yuan, Xi-Guang Chen, Ya Liu*. Nanosystems as curative platforms for allergic disorder management. Journal of Materials Chemistry B. 2021, 9, 1729-1744. (IF: 6.331)

23. Andi Zhang#, Ya Liu#, Di Qin, Mengjie Sun, Ting Wang, Xiguang Chen*. Research status of self-healing hydrogel for wound management: A review. International Journal of Biological Macromolecules 164 (2020) 2108–2123. (IF: 6.953)

24. Mengjie Sun, Ting Wang, Jianhui Pang, Xiguang Chen, Ya Liu*. Hydroxybutyl Chitosan Centered Biocomposites for Potential Curative Applications: A Critical Review. Biomacromolecules. 2020, 21, 1351-1367.(IF: 6.988)

25. Xuqian Lang, Ting Wang, Mengjie Sun, Xiguang Chen, Ya Liu*. Advances and applications of chitosan-based nanomaterials as oral delivery carriers: A review. International Journal of Biological Macromolecules 154 (2020) 433-445. (IF: 6.953)


26. Congshan Yuan#, Ya Liu#, Ting Wang, Mengjie Sun, and Xiguang Chen*. Nanomaterials as Smart Immunomodulator Delivery System for Enhanced Cancer Therapy. ACS Biomaterials Science & Engineering.doi.org/10.1021/acsbiomaterials.0c00804. (IF: 4.749)


27. Zhenwei Deng, Ting Wang, Xiguang Chen, Ya Liu*. Applications of chitosan based biomaterials: a focus on dependent antimicrobial properties. Marine Life Science & Technology.2, (2020) 398–413.


28. Mengjie Sun, Xiaoping Yu, Ting Wang, Shichao Bi, Ya Liu*, Xiguang Chen*. Nasal adaptive chitosan-based nano-vehicles for anti-allergic drug delivery. International Journal of Biological Macromolecules 135 (2019) 1182-1192 (IF: 6.953)

29. Ting Wang, FangqinWang, Mengjie Sun, Meiping Tian, Yuzhi Mu, Xiguang Chen, Ya Liu*. Gastric environment-stable oral nanocarriers for in situ colorectal cancer therapy. International Journal of Biological Macromolecules 139 (2019) 1035-1045. (IF: 6.953)

30. Mei-Ping Tian, Rui-Xi Song, Ting Wang, Meng-Jie Sun, Ya Liu*, Xi-Guang Chen*. Inducing sustained release and improving oral bioavailability of curcumin via chitosan derivatives-coated liposomes. International Journal of Biological Macromolecules.120 (2018) 702710. (IF: 6.953)

31. Zixian Bao, Changqing Jiang, Zhiguo Wang, Qiuxia Ji, Guohui Sun, Shichao Bi, Ya Liu*, Xiguang Chen*. The influence of solvent formulations on thermosensitive hydroxybutyl chitosan hydrogel as a potential delivery matrix for cell therapy. Carbohydrate Polymers170 (2017) 80–88. (IF: 9.381)

32. Juan Wang, Ming Kong, Zhenjin Zhou, Dong Yan, Xiaoping Yu, Xiaojie Cheng, Chao Feng, Ya Liu*, Xiguang Chen*. Mechanism of surface charge triggered intestinal epithelial tight junction opening upon chitosan nanoparticles for insulin oral delivery. Carbohydrate Polymers157 (2017) 596–602. (IF: 9.381)

33. Guixue Xia, Ya Liu*, Meiping Tian, Ping Gao, Zixian Bao, Xiaoyu Bai, Xiaoping Yu, Xuqian Lang, Shihao Hu and Xiguang Chen*. Nanoparticles/thermosensitive hydrogel reinforced with chitin whiskers as a wound dressing for treating chronic wounds. Journal of Materials Chemistry B5 (2017) 3172—3185. (IF: 6.331)

34. Zixian Bao, Ping Gao, Guixue Xia, Zhiguo Wang, Ming Kong, Chao Feng, Xiaojie Cheng*, Ya Liu* and Xiguang Chen*. A thermosensitive hydroxybutyl chitosan hydrogel as a potential co-delivery matrix for drugs on keloid inhibition. Journal of Materials Chemistry B 4(2016) 3936-3944. (IF: 6.331)

35. Ping Gao, Guixue Xia, Zixian Bao, Chao Feng, Xiaojie Cheng, Ming Kong, Ya Liu*, Xiguang Chen*. Chitosan based nanoparticles as protein carriers for efficient oral antigen delivery. International Journal of Biological Macromolecules 91 (2016) 716–723. (IF: 6.953)

36. Fangqin Wang, Guixue Xia, Xuqian Lang, Xuanxuan Wang, Zixian Bao, Zeenat Shah, Xiaojie Cheng, Ming Kong, Chao Feng, Ya Liu*, Xiguang Chen*. Influence of the graft density of hydrophobic groups on thermo-responsive nanoparticles for anti-cancer drugs delivery. Colloids and Surfaces B: Biointerfaces148 (2016) 147–156. (IF: 5.268)

二.专利

1.刘雅,张安迪,陈西广. 一种兼具自愈性和黏附性的复合水凝胶的制备方法,国家发明专利、申请号:201911245875.7

2.刘雅,孙梦杰,陈西广, 程晓杰, 孔明, 冯超.  一种兼具抑制组胺释放与组胺受体拮抗功能的纳米颗粒的制备方法, 国家发明专利、申请号201811503207.5

3.刘雅, 田美平, 陈西广, 程晓杰, 孔明, 冯超. 一种具有黏附性和抑菌性的温敏性水凝胶的制备方法, 国家发明专利、申请号201711409615.X

4.刘雅, 夏桂雪, 陈西广, 程晓杰, 孔明, 冯超.一种甲壳素晶须/羟丁基壳聚糖温敏水凝胶的制备方法, 国家发明专利、申请号201610884477.X

5.刘雅, 王方勤,陈西广,程晓杰, 孔明,冯超.一种pH温度双敏感性壳聚糖纳米颗粒的制备方法, 国家发明专利、申请号201610884478.4

6.刘雅,陈西广,程晓杰,孔明,冯超. 一种壳寡糖透明质酸复合纳米微粒的制备方法,国家发明专利、专利号ZL20141069938380.2