刘光磊

发布者:杨光发布时间:2020-01-19浏览次数:3638

 

姓名:刘光磊

学历/职称/职务:博士/副教授/硕士生导师

联系方式:

邮箱:liugl@ouc.edu.cn

地址:山东省青岛市市南区鱼山路5号中国海洋大学科学馆313

科研领域描述:海洋微生物多糖水解酶的结构功能研究及酶工程改造;海洋酵母菌天然产物的代谢途径和调控机制研究及代谢工程改造。

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学习工作简历:

201412月至今:中国海洋大学海洋生命学院副教授

20137—201411月:中国海洋大学海洋生命学院讲师

20127—20136月:中国科学院青岛生物能源与过程研究所助理研究员

20089—20126月:中国海洋大学海洋生命学院微生物学专业博士

20049—20086月:中国海洋大学海洋生命学院生物科学专业学士

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代表性成果:

一、近5年主持的科研项目:

1)谷氨酰胺富集重复区及其重复度变异对于马克斯克鲁维酵母糖酵解调控因子KmGcr1p转录活性的影响及作用机制, 国家自然科学基金面上项目,58万,2020.01-2023.12

2)耐热工程菊粉内切酶的构建及其在利用菊粉生产益生果寡糖中的应用,山东省重点研发计划,15万,2019.01-2020.12

3)κ-卡拉胶酶中碳水化合物结合模块在酶催化中的作用及其底物识别的分子机制,国家自然科学基金面上项目,25万,2018.01-2019.12

4)微生物菊粉酶C末端结构域的功能研究,国家自然科学基金青年基金项目,24万,2015.01-2017.12

5)高效利用菊芋发酵产生物乙醇的酵母工程菌株构建的研究,中国博士后科学基金面上一等资助,8万,2014.9-2015.12

  

二、近5年发表论文:

1)Chen, T. J. #, Liu, G. L.#, Chen, L., Yang, G., Hu, Z., Chi, Z. M., & Chi, Z. (2020). Alternative primers are required for pullulan biosynthesis in Aureobasidium melanogenum P16. International Journal of Biological Macromolecules.

2)Chen, L. #, Chi, Z.*, Liu, G. L. #, Xue, S. J., Wang, Z. P. #, Hu, Z., & Chi, Z. M.. Improved pullulan production by a mutant of Aureobasidium melanogenum TN3-1 from a natural honey and capsule shell preparation. International journal of biological macromolecules, 2019, 141, 268-277.

3)Mao, W. #, Han, Y. #, Wang, X., Zhao, X., Chi, Z., Chi, Z.M., & Liu, G.* A new engineered endo-inulinase with improved activity and thermostability: Application in the production of prebiotic fructo-oligosaccharides from inulin. Food chemistry,2019, 294, 293-301.

4)Wang, M. #, Mao, W. #, Wang, X., Li, F., Wang, J., Chi, Z., Chi, Z. M. & Liu, G.* Efficient simultaneous production of extracellular polyol esters of fatty acids and intracellular lipids from inulin by a deep-sea yeast Rhodotorula paludigena P4R5. Microbial cell factories, 2019, 18(1), 149.

5)Zhao Y#, Chi Z#, Xu Y, Shi N, Chi Z, & Liu GL*. High-level extracellular expression of κ-carrageenase in Brevibacillus choshinensis for the production of a series of κ-carrageenan oligosaccharides. Process Biochemistry, 2018, 64, 83-92.

6)Han YZ, Zhou CC., Xu, YY., Yao JX., Chi, Z, Chi ZM., & Liu GL*. High-efficient production of fructo-oligosaccharides from inulin by a two-stage bioprocess using an engineered Yarrowia lipolytica strain. Carbohydrate Polymers, 2017, 173, 592.

7)Shi N, Mao W, He X, Chi Z, Chi Z, & Liu G*. Co-expression of Exo-inulinase and Endo-inulinase Genes in the Oleaginous Yeast Yarrowia lipolytica for Efficient Single Cell Oil Production from Inulin. Applied biochemistry and biotechnology, 2017, 1-13.

8)Chi Z#, Liu GL#, Liu CG, Chi ZM. Poly (β-l-malic acid)(PMLA) from Aureobasidium spp. and its current proceedings.Applied microbiology and biotechnology, 2016, 100(9): 3841-3851.

9)Liu Y, Zhou S H, Chen YR, Chi Z, Chi ZM, Liu GL*. Synergistic effect between the recombinant exo-inulinase and endo-inulinase on inulin hydrolysis.Journal of Molecular Catalysis B: Enzymatic, 2016, 128: 27-38.

10)Zhou SH, Liu Y, Zhao YJ, Chi Z, Chi ZM, Liu GL*.Enhanced exo-inulinase activity and stability by fusion of an inulin-binding module. Applied microbiology and biotechnology, 2016, 100(18): 8063–8074

11)Liu GL, Chi Z, Wang GY, Wang ZP, Li Y, Chi ZM*. Yeast killer toxins, molecular mechanisms of their action and their applications. Crit Rev Biotechnol. 2015, 352222-234

12)Liu GL, Fu GY, Chi Z, Chi ZM*. Enhanced expression of the codon-optimized exo-inulinase gene from the yeast Meyerozyma guilliermondii in Saccharomyces sp. W0 and bioethanol production from inulin. Appl Microbiol Biotechnol. 2014, 98(21): 9129-9138

  

Curriculum Vitae

Name: Guanglei Liu

Title: Dr & Associate professor

Contact

Emailliugl@ouc.edu.cn

AddressCollege of Marine Life Science, Ocean University of China, No. 5 Yushan Road, Qingdao, P.R.China,

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Experiences:

2014.12- , Ocean University of China, Associate professor

2013.07-2014.11, Ocean University of China, Lecturer

2012.7-2013.6, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Research assistant

2008.09-2012.06, Ocean University of China, Microbiology, D.Sc

2004.09-2008.06, Ocean University of China, Biology, B.Sc.