姓名：刘光磊
学历/职称/职务：博士/教授/博士生导师
联系方式：
邮箱：liugl@ouc.edu.cn
地址：山东省青岛市市南区鱼山路5号中国海洋大学科学馆313
科研领域描述：酵母菌碳代谢及产物合成中的关键蛋白功能、途径解析和重构以及调控机制的研究。
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学习工作简历：
2014年12月—2020年12月：中国海洋大学海洋生命学院副教授
2013年7月—2014年11月：中国海洋大学海洋生命学院讲师
2012年7月—2013年6月：中国科学院青岛生物能源与过程研究所助理研究员
2008年9月—2012年6月：中国海洋大学海洋生命学院微生物学专业博士
2004年9月—2008年6月：中国海洋大学海洋生命学院生物科学专业学士
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代表性成果：
一、近期主持的科研项目：
1)医用多糖整合型高效细胞工厂构建与一步发酵合成，国家重点研发计划课题骨干，80万，2022.01-2025.12
2)谷氨酰胺富集重复区及其重复度变异对于马克斯克鲁维酵母糖酵解调控因子KmGcr1p转录活性的影响及作用机制，国家自然科学基金面上项目，58万，2020.01-2023.12
3)耐热工程菊粉内切酶的构建及其在利用菊粉生产益生果寡糖中的应用,山东省重点研发计划，15万，2019.01-2020.12
4)κ-卡拉胶酶中碳水化合物结合模块在酶催化中的作用及其底物识别的分子机制，国家自然科学基金面上项目，25万，2018.01-2019.12
5)微生物菊粉酶C末端结构域的功能研究，国家自然科学基金青年基金项目，24万，2015.01-2017.12
二、近期发表的SCI论文：
1)Li, F.; Wang, M.; Chi, Z.; Zhang, Z.; Wang, X.; Xing, M.; Chi, Z.; Liu, G. *, A novel transcriptional activation mechanism of inulinase gene in Kluyveromyces marxianus involving a glycolysis regulator KmGcr1p with unique and functional Q-rich repeats. Mol. Microbiol. 2022, 117 (5), 1063-1079.
2)Zhu, Y. #; Han, Y. #; Liu, G. #; Bian, Z.; Yan, X.; Li, Y.; Long, H.; Yu, G.; Wang, Y., Novel indole-mediated potassium ion import system confers a survival advantage to the Xanthomonadaceae family. ISME J 2022.
3)Xing, M.; Wang, Y.; Zhao, Y.; Chi, Z.; Chi, Z.; Liu, G.*, C-Terminal bacterial immunoglobulin-like domain of kappa-carrageenase serves as a multifunctional module to promote kappa-carrageenan hydrolysis. J Agric. Food. Chem. 2022, 70 (4), 1212-1222.
4)Chen, C.; Wu, Q.; Ke, Q.; Wang, T.; Zhang, Y.; Wei, F.; Wang, X.; Liu, G. *, Implementation of novel boolean logic gates for IMPLICATION and XOR functions using riboregulators. Bioengineered 2022, 13 (1), 1235-1248
5)Yu, G.; Wang, X.; Zhang, C.; Chi, Z.; Chi, Z.M.; Liu, G. *. Efficient production of mannosylerythritol lipids by a marine yeast Moesziomyces aphidis XM01 and their application as self-assembly nanomicelles. Mar. Life Sci. Technol. (2022).
6)Wei, X. #; Liu, G. L. #; Jia, S. L.; Chi, Z.; Hu, Z.; Chi, Z. M., Pullulan biosynthesis and its regulation in Aureobasidium spp. Carbohydr. Polym. 2021, 251, 117076.
7)Liu, G. #; Zhao, X. #; Chen, C.; Chi, Z.; Zhang, Y.; Cui, Q.; Chi, Z.; Liu, Y. J., Robust production of pigment-free pullulan from lignocellulosic hydrolysate by a new fungus co-utilizing glucose and xylose. Carbohydr. Polym. 2020, 241, 116400.
8)Chen, T. J. #; Liu, G. L. #; Chen, L.; Yang, G.; Hu, Z.; Chi, Z. M.; Chi, Z., Alternative primers are required for pullulan biosynthesis in Aureobasidium melanogenum P16. Int. J. Biol. Macromol. 2020, 147, 10-17.
9)Xue, S. J. #; Liu, G. L. #; Chi, Z. #; Gao, Z. C.; Hu, Z.; Chi, Z. M., Genetic evidences for the core biosynthesis pathway, regulation, transport and secretion of liamocins in yeast-like fungal cells. Biochem. J 2020, 477 (5), 887-903.
10)Mao, W.; Han, Y.; Wang, X.; Zhao, X.; Chi, Z.; Chi, Z.; Liu, G. *, A new engineered endo-inulinase with improved activity and thermostability: Application in the production of prebiotic fructo-oligosaccharides from inulin. Food Chem. 2019, 294, 293-301
11)Chen, L. #; Chi, Z.; Liu, G. L. #; Xue, S. J.; Wang, Z. P. #; Hu, Z.; Chi, Z. M., Improved pullulan production by a mutant of Aureobasidium melanogenum TN3-1 from a natural honey and capsule shell preparation. Int. J. Biol. Macromol. 2019, 141, 268-277.
12)Wang, M.; Mao, W.; Wang, X.; Li, F.; Wang, J.; Chi, Z.; Chi, Z.; Liu, G. *, Efficient simultaneous production of extracellular polyol esters of fatty acids and intracellular lipids from inulin by a deep-sea yeast Rhodotorula paludigena P4R5. Microb. Cell Fact. 2019, 18 (1), 149.
13)Han, Y. Z.; Zhou, C. C.; Xu, Y. Y.; Yao, J. X.; Chi, Z.; Chi, Z. M.; Liu, G. L. *, High-efficient production of fructo-oligosaccharides from inulin by a two-stage bioprocess using an engineered Yarrowia lipolytica strain. Carbohydr. Polym. 2017, 173, 592-599.
14)Liu, G. L.; Chi, Z.; Wang, G. Y.; Wang, Z. P.; Li, Y.; Chi, Z. M., Yeast killer toxins, molecular mechanisms of their action and their applications. Crit. Rev. Biotechnol. 2015, 35 (2), 222-34.
15)Liu, G. L. #; Chi, Z. #; Chi, Z. M., Molecular characterization and expression of microbial inulinase genes. Crit. Rev. Microbiol. 2013, 39 (2), 152-65.
Curriculum Vitae
Name: Guanglei Liu
Title: Dr. & Professor
Contact： Email：liugl@ouc.edu.cn. Address：College of Marine Life Science, Ocean University of China, No. 5 Yushan Road, Qingdao, P.R.China,
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Experiences:
2021.1-, Ocean University of China, Professor
2014.12-2020.12, Ocean University of China, Associate professor
2013.07-2014.11, Ocean University of China, Lecturer
2012.7-2013.6, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Research assistant
2008.09-2012.06, Ocean University of China, Microbiology, Ph.D
2004.09-2008.06, Ocean University of China, Biology, B.S.
