姓名：高珊
学历/职称/职务：博士，筑峰二层次教授 ，博士生导师
联系方式：
邮箱：shangao@ouc.edu.cn （欢迎报考我们实验室，有意向的同学请发邮件~ ）
电话：0532-82031935
地址：中国海洋大学鱼山校区达尔文馆217室
网址：https://scxy.ouc.edu.cn/lplb/
科研方向：
主要以单细胞真核模式生物--嗜热四膜虫（Tetrahymena thermophila）为研究体系，从事表观遗传学研究，聚焦DNA N6-甲基腺嘌呤（6mA）的调控机制和功能分化。
教育经历：
005/09 – 2011/06 中国海洋大学，理学博士
2006/10 – 2007/03 德国基尔大学，中德交换博士生
2009/01 – 2010/12 美国密歇根大学，“国家建设高水平大学公派研究生项目” 联合培养博士生
2001/09 – 2005/06 中国海洋大学，理学学士
工作经历：
2021/11至今，中国海洋大学，海洋生命学院/海洋生物多样性与进化研究所，“筑峰人才工程”第二层次特聘教授
2017/12至今，中国海洋大学，海洋生命学院/海洋生物多样性与进化研究所，“筑峰人才工程”第三层次特聘教授
2014/03 –2017/1，中国海洋大学，海洋生命学院/海洋生物多样性与进化研究所，“青年英才工程”第一层次特聘教授
2011/07 – 2014/01，美国密歇根大学，病理学系, 博士后
主持的科研项目及人才基金项目情况：
1. 1. 国家自然科学基金杰出青年基金，2022-2026、400万元、在研、主持。
2. 2.山东省自然科学基金重大项目，2025-2027、60万元、在研、主持。
3. 3.国家自然科学基金面上项目，2021-2024、58万、已结题、主持。
4. 4.国家“万人计划”青年拔尖人才，2018-2020、200万元、已结题、主持。
5. 5.山东省重大科技创新工程专项，2019-2020、185万元、在研、主持。
6. 6.山东省泰山学者青年专家计划，2017-2021、50万元、在研、主持。
7. 7.中国海洋大学国家杰出青年科学基金培育计划，2018-2020、100万元、已结题、主持。
8. 8. 国家自然科学基金优秀青年基金项目，2016/01-2018/12、150万元、已结题、主持。
9. 9.山东省杰出青年基金项目，2018/07-2020/07、60万元、已结题、主持。
10. 10.青岛海洋科学与技术国家实验室“鳌山人才”优秀青年学者项目，2015/12-2017/12、150万、已结题、主持。
11. 11.国家自然科学基金面上项目，2015/01-2016/12、30万元、已结题、结题。
12. 12.山东省自然科学基金青年基金项目，2014/08-2017/08、12万元、已结题、结题。
13. 13.中国海洋大学基本科研业务费，2015/12-2018/12、200万元、已结题、主持。
14. 14.中国海洋大学“英才计划”特别资助项目，60万元、已结题、主持。
代表性文章（*通讯）：
Yuanyuan Wang, Bei Nan, Fei Ye, Zhe Zhang, Wentao Yang, Bo Pan, Fan Wei, Lili Duan, Haicheng Li, Junhua Niu, Aili Ju, Yongqiang Liu, Dantong Wang, Wenxin Zhang, Yifan Liu*, Shan Gao* (2025). Dual modes of DNA N6-methyladenine maintenance by distinct methyltransferase complexes. Proceedings of the National Academy of Sciences of the United States of America, 122, e2413037121.
Ting Cheng, Jiachen Zhang, Haicheng Li, Jinghan Diao, Wenxin Zhang, Junhua Niu, Kensuke Kataoka, Shan Gao* (2025). Identification and characterization of the de novo methyltransferases for eukaryotic N6-methyladenine (6mA). Science Advances, 11, eadq4623.
Fei Ye, Xiao Chen, Yuan Li, Aili Ju, Yalan Sheng, Lili Duan, Jiachen Zhang, Zhe Zhang, Khaled A S Al-Rasheid, Naomi A Stover, Shan Gao* (2025). Comprehensive genome annotation of the model ciliate Tetrahymena thermophila by in-depth epigenetic and transcriptomic profiling. Nucleic Acids Research, 53, gkae1177.
Lili Duan, Haicheng Li, Aili Ju, Zhe Zhang, Junhua Niu, Yumiao Zhang, Jinghan Diao, Yongqiang Liu, Honggang Ma, Ni Song, Kensuke Kataoka, Shan Gao*, Yuanyuan Wang* (2025). Methyl-dependent auto-regulation of the DNA N6-adenine methyltransferase AMT1 in the unicellular eukaryote Tetrahymena thermophila. Nucleic Acids Research, 53, gkaf022.
Haicheng Li, Junhua Niu, Yalan Sheng, Yifan Liu*, Shan Gao* (2025). SMAC: identifying DNA N6-methyladenine (6mA) at the single-molecule level using SMRT CCS data. Briefings in Bioinformatics, 26, bbaf153.
Yongqiang Liu, Junhua Niu, Fei Ye, Therese Solberg, Borong Lu, Chundi Wang, Mariusz Nowacki, Shan Gao* (2024). Dynamic DNA N6-adenine methylation (6mA) governs the encystment process, showcased in the unicellular eukaryote Pseudocohnilembus persalinus. Genome Research, 34, 256-271. (Nature index)
Yalan Sheng, Yuanyuan Wang, Wentao Yang, Xue Qing Wang, Jiuwei Lu, Bo Pan, Bei Nan, Yongqiang Liu, Fei Ye, Chun Li, Jikui Song, Yali Dou, Shan Gao*, Yifan Liu* (2024). Semiconservative transmission of DNA N6-adenine methylation in a unicellular eukaryote. Genome Research, 34, 740-756. (Nature index)
Jing Xu, Xiaolu Zhao, Fengbiao Mao, Venkatesha Basrur, Beatrix Ueberheide, Brian T. Chait, C. David Allis, Sean D. Taverna, Shan Gao*, Wei Wang*, Yifan Liu* (2021). A Polycomb repressive complex is required for RNAi-mediated heterochromatin formation and dynamic distribution of nuclear bodies. Nucleic Acids Research, 49, 5407-5425. (NAR Breakthrough Articles)
Weibo Zheng, Chundi Wang, Michael Lynch*, Shan Gao* (2021). The compact macronuclear genome of the ciliate Halteria grandinella: a transcriptome-like genome with 23,000 nanochromosomes. mBio, 12, e01964-20.
Yalan Sheng, Lili Duan, Ting Cheng, Yu Qiao, Naomi A. Stover, Shan Gao* (2020). The completed macronuclear genome of a model ciliate Tetrahymena thermophila and its application in genome scrambling and copy number analyses. Science China Life Sciences, 63, 1534-1542.
Yuanyuan Wang, Yalan Sheng, Yongqiang Liu, Wenxin Zhang, Ting Cheng, Lili Duan, Bo Pan, Yu Qiao, Yifan Liu, Shan Gao* (2019). A distinct class of eukaryotic MT-A70 methyltransferases maintain symmetric DNA N6-adenine methylation at the ApT dinucleotides as an epigenetic mark associated with transcription. Nucleic Acids Research, 47, 11771-11789.
Xiaolu Zhao, Jie Xiong, Fengbiao Mao, Yalan Sheng, Xiao Chen, Lifang Feng, Wen Dui, Wentao Yang, Aurelie Kapusta, Cedric Feschotte, Rebert s. Coyne, Wei Miao, Shan Gao*, Yifan Liu* (2019). RNAi-dependent Polycomb repression controls transposable elements in Tetrahymena. Genes & Development,33, 348-364.
Jing Xu, Xiao Li, Weibo Song, Wei Wang*, Shan Gao* (2019). Cyclin Cyc2p is required for micronuclear bouquet formation in Tetrahymena thermophila.Science China Life Sciences,62, 668-680.
Xiao Chen, Yurui Wang, Yalan Sheng, Alan Warren, Shan Gao* (2018). GPSit: An automated method for evolutionary analysis of nonculturable ciliated microeukaryotes. Molecular Ecology Resources, 18, 700-713.
Yuanyuan Wang, Xiao Chen, Yalan Sheng, Yifan Liu, Shan Gao* (2017). N6-adenine DNA methylation is associated with the linker DNA of H2A.Z-containing well-positioned nucleosomes in Pol II-transcribed genes in Tetrahymena. Nucleic Acids Research, 45, 11594-11606.
Xiaolu Zhao, Yuanyuan Wang, Yurui Wang, Yifan Liu, Shan Gao* (2017). Histone methyltransferase TXR1 is required for both H3 and H3.3 lysine 27 methylation in the well-known ciliated protist Tetrahymena thermophila. Science China Life Sciences, 60, 264-270.
Xiao Chen, Shan Gao*, Yifan Liu, Yuanyuan Wang, Yuri Wang, Weibo Song* (2016). Enzymatic and chemical mapping of nucleosome distribution in purified micro- and macronuclei of the ciliated model organism, Tetrahymena thermophila. Science China Life Sciences, 59, 909-919.
