冯超

发布者:杨光发布时间:2020-02-20浏览次数:2670

冯超,博士,副教授,硕士生导师

一、联系方式:

邮箱:fengchao@ouc.edu.cn

电话:0532-82032215

地址:山东青岛鱼山路5号中国海洋大学海洋生命学院科学馆210

二、学习与工作经历:

2014/09-至今中国海洋大学,海洋生命学院,讲师/副教授

2014/09-2017/09中国海洋大学,海洋科学博士后流动站,博士后

2012/09-2014/06,中国海洋大学,海洋生命学院,生物化学与分子生物学,博士

2009/09-2012/06,中国海洋大学,海洋生命学院,生物工程,硕士

2005/09-2009/06,中国海洋大学,海洋生命学院,生物技术,学士

三、研究方向:

致力于海洋生物材料发掘与医用新材料开发领域,研究方向包括海洋硅藻医用新材料的生物制造研究;海洋生物纳米材料功能化构建技术与应用研究;海洋生物医用材料智能化技术与应用研究。主持国家自然科学基金青年项目1项、中国博士后基金面上项目1项、山东省自然科学基金项目2项(博士、青年)、青岛市科技项目2项(自主研发、应用),校级项目1项,技术转化项目2项。以第一或通讯作者发表SCI学术论文23篇,以第一发明人授权国家发明专利5项。

四、科研项目:

1.圆筛藻生物矿化硅的促凝血机理及构效关系研究,81801846,国家自然科学基金,2019.01-2021.1224万,主持

2.硅藻生物矿化硅的促凝血活性及应用基础研究,ZR2019QD005,山东省自然科学基金,2019.07-2022.0615万,主持

3.硅藻基止血粉成果相关的2项国内专利权转让,20200018,技术转化项目,2020.0140万,主持

4.硅藻基止血粉材料专项技术服务,20190185,科技服务项目,2019.08-2022.0851万,主持

5.程序化控释纳米凝胶固定化多层微分散体系的构建及抗乳腺癌作用,BS2015SW010,山东省自然科学基金,2015.07-2017.078万,主持

6.具有“表面电荷翻转”和P-gp抑制双重作用智能纳米胶束的构建及其用于抗肿瘤药物口服递送的应用基础研究,16-5-1-70-jch,青岛市科技发展计划,2016.09-2018.0810万,主持

7.环境响应型口服多层微分散体系的构建及抗结直肠癌作用,2016M592246,中国博士后基金,2015.01-2016.125万,主持

8.纳米凝胶固定化多层控释载体在乳腺癌口服化疗中的应用,861605040058,青岛市博士后资助,2015.10-2017.095万,主持

9.细菌仿生硅藻基口服胰岛素递药体系的构建及其透粘膜机理的研究,201513045,青年教师科研专项基金,2015.01-2016.1210万,主持

10.细胞质膜钙泵(PMCA1)与钙网蛋白(CRT)正反馈调控介导持续功能矫形力诱发成肌细胞凋亡的机制研究,31870929,国家自然科学基金,2019.01-2022.12,80万,参与

11.微藻生物矿化硅复合医用敷料研究,U1706212,国家自然科学基金,2018.01-2021.12332万,参与

12.淋巴血液多靶点纳米复合体系的构建及其时序响应性递药的调控研究,31300786,国家自然科学基金,2014.01-2016.1220万,参与

13.沙蚕功效成分研究及特医配方食品研发,2016YYSP014,山东省科技攻关,2016.12-2019.12100万,参与

五、代表性成果:

科研论文(第一作者及通讯作者*):

1.Yuzhi Mu, Guangsheng Wu, ChangSu, Yao Dong, Kaichao Zhang, Jing Li, Xiaojie Sun, YangLi, Xiguang Chen, Chao Feng*, pH-sensitive amphiphilic chitosan-quercetin conjugate for intracellular delivery of doxorubicin enhancement. Carbohydrate Polymers, 2019, 223, 115072. IF= 6.044, SCI一区

2.Jing Li1, Jichang Han1, Qingjie Sun, Yanan Wang, Yuzhi Mu, Kaichao Zhang, Xiaoyu Dou, Ming Kong, Xiguang Chen, Chao Feng*, Biosynthetic calcium-doped biosilica with multiple hemostatic properties for hemorrhage control. Journal of Materials Chemistry B, 2018, 6, 7834-7841.IF= 5.047, SCI二区

3.Congcong Qu, Zixian Bao, Xin Zhang, Zhiguo Wang, Jizhen Ren, Zhongzheng Zhou, Meiping Tian, Xiaojie Cheng, Xiguang Chen, Chao Feng*, A thermosensitive RGD-modified hydroxybutyl chitosan hydrogel as a 3D scaffold for BMSCs culture on keloid treatment. International Journal of Biological Macromolecules, 2019, 125, 78-86.IF= 4.784, SCI二区

4.Changqing Jiang1, Guohui Sun1, Zhongzheng Zhou, Zixian Bao, Xuqian Lang, Jianhui Pang, Qingjie Sun, Yang Li, XinZhang, Chao Feng*, XiguangChen, Optimization of the preparation conditions of thermo-sensitive chitosan hydrogel in heterogeneous reaction using response surface methodology. International Journal of Biological Macromolecules, 2019, 121, 293-300.IF= 4.784, SCI二区

5.Chao Feng*, Jing Li, Guang Sheng Wu, Yu Zhi Mu, Ming Kong, Chang Qing Jiang, Xiao Jie Cheng, Ya Liu, Xi Guang Chen*, Chitosan-Coated Diatom Silica as Hemostatic Agent for Hemorrhage Control. ACS Applied Materials & Interfaces, 2016, 8, 34234-34243. IF= 7.504, SCI一区TOP

6.Chao Feng*, Jing Li, Ming Kong, Ya Liu, Xiao Jie Cheng, Yang Li, Hyun JinPark, Xi Guang Chen*, Surface charge effect on mucoadhesion of chitosan based nanogels for local anti-colorectal cancer drug delivery. Colloids and surfaces. B, Biointerfaces, 2015, 128, 439-447. IF= 3.902, SCI二区

7.Chao Feng*, Jing Li, Yuzhi Mu, Ming Kong, Yang Li, Mazhar AliRaja, Xiao Jie Cheng, Ya Liu, Xi Guang Chena*, Multilayer micro-dispersing system as oral carriers for co-delivery of doxorubicin hydrochloride and P-gp inhibitor. International Journal of Biological Macromolecules, 2017, 94, 170-180. IF= 3.909, SCI二区

8.Chao Feng*, Jing Li, Yuzhi Mu, Polysaccharide based multilayer micro-dispersing system as oral carriers for co-delivery of doxorubicin hydrochloride and P-gp inhibitor. Journal of Controlled Release, 2017, 259, E16-E17. (会议论文,IF= 7.877, SCI一区

9.Chao Feng, Guohui Sun, Zhiguo Wang, Xiaojie Cheng, Hyunjin Park, Dongsu Cha, Ming Kong*, Xiguang Chen*. Transport mechanism of doxorubicin loaded chitosan based nanogels across intestinal epithelium, European Journal of Pharmaceutics and Biopharmaceutics, 2014, 87, 197-20. IF= 3.383, SCI二区

10.Chao Feng, Ruixi Song, Guohui Sun, Ming Kong, Yang Li, Zixian Bao, Xiaojie Cheng, Dongsu Cha, Hyunjin Park*, Xiguang Chen*. Immobilization of coacervate microcapsules in multilayer sodium alginate beads for efficient oral anticancer drug delivery, Biomacromolecules, 2014, 15, 985-996. IF= 5.750, SCI一区

11.Chao Feng, Zhiguo Wang, Changqing Jiang, Ming Kong, Xuan Zhou, Yang Li, Xiaojie Cheng*, Xiguang Chen*, Chitosan/o-carboxymethyl chitosan nanoparticles for efficient and safe oral anticancer drug delivery: in vitro and in vivo evaluation, International Journal of Pharmaceutics, 2013, 457, 158-167. IF= 3.785, SCI二区

12.Guangsheng Wua1, Chao Feng1, Jingjing Quan, Zhongshan Wang, Wei Wei, Shengqi Zang, Shuai Kang, Guangyan Hui, Xiguang Chen*, Qintao Wang*, In situ controlled release of stromal cell-derived factor-1alpha and antimiR-138 for on-demand cranial bone regeneration. Carbohydrate Polymers 2018, 182, 215-224. IF= 5.158, SCI一区

13.Guangsheng Wu1, Chao Feng1, Guangyan Hui, Zhongshan Wang, Jun Tan, Lankun Luo, Peng Xue, Qintao Wang*, XiguangChen*, Improving the osteogenesis of rat mesenchymal stem cells by chitosan-based-microRNA nanoparticles. Carbohydrate Polymers, 2016, 138, 49-58. IF= 4.811, SCI一区

14.Guohui Suna1, ChaoFeng1, Changqing Jiang, Tingting Zhang, Zixian Bao, Yajun Zuo, Ming Kong, Xiaojie Cheng*, Ya Liu, Xiguang Chen*, Thermo-responsive hydroxybutyl chitosan hydrogel as artery intervention embolic agent for hemorrhage control. International Journal of Biological Macromolecules, 2017, 105, 566-574. IF= 3.909, SCI二区

15.Yang Li1, Chao Feng1, Jing Li, Yuzhi Mu, Ya Liu, Ming Kong, Xiaojie Cheng*, XiguangChen*, Construction of multilayer alginate hydrogel beads for oral delivery of probiotics cells. International Journal of Biological Macromolecules, 2017, 105, 924-930. IF= 3.909, SCI二区

16.Mengxue Xu1, Chao Fenga1, Juan Wang, Xuqian Lang, Guixue Xia, Xiaoping Yu, Qiuxia Ji, Xiaojie Cheng, Ming Kong, Ya Liu, Xiguang Chen*, In vitro heterogeneous degradation of alginate and its validation of different molecular weight on blood biocompatibility, Journal of Biomaterials Science, Polymer Edition, 28 (2017) 380–393.IF= 1.911, SCI三区

17.Guohui Sun1, Chao Feng1, Ming Kong, Xiaojie Cheng, Jiaojiao Bing, Guixue Xia, Zixian Bao, Hyunjin Park*, and Xiguang Chen*, Development of part-dissolvable chitosan fibers with surface N-succinylation for wound care dressing, Frontiers of Materials Science, 9(2015) 272-281. IF= 1.354, SCI三区

18.Lulu Wang, Kehou Pan, Jing Li, Yun Li, Baohua Zhu, Yanan Wang, Chao Feng*, Jichang Han*, Influence of the physicochemical characteristics of diatom frustules on hemorrhage control. Biomaterials science, 2019, 7, 1833-1841. IF= 5.251, SCI二区

19.Yuzhi Mu1, Yangmu Fu1, Jing Li, Xiaoping Yu, YangLi, Yanan Wang, Xuanjin Wu, Kaichao Zhang, MingKong, Chao Feng*, XiguangChen*, Multifunctional quercetin conjugated chitosan nano-micelles with P-gp inhibition and permeation enhancement of anticancer drug. Carbohydrate Polymers, 2019, 203, 10-18. IF= 6.044, SCI一区

20.Yanan Wang1, Yangmu Fu1, JingLi, Yuzhi Mu, Xin Zhang, Kaichao Zhang, Mengqi Liang, Chao Feng*, Xiguang Chen*, Multifunctional chitosan/dopamine/diatom-biosilica composite beads for rapid blood coagulation. Carbohydrate Polymers 2018, 200, 6-14. IF= 6.044, SCI一区

21.Guohui Sun, Xin Zhang, Zixian Bao, Xuqian Lang, Zhongzheng Zhou, Yang Li, Chao Feng*, Xiguang Chen*, Reinforcement of thermoplastic chitosan hydrogel using chitin whiskers optimized with response surface methodology. Carbohydrate Polymers, 2018, 189, 280-288. IF= 6.044, SCI一区

22.Juan Wang, Mengxue Xu, Xiaojie Cheng, Ming Kong, Ya Liu, ChaoFeng*, Xiguang Chen*, Positive/negative surface charge of chitosan based nanogels and its potential influence on oral insulin delivery. Carbohydrate Polymers, 2016, 136, 867-874. IF= 4.811, SCI一区

23.JingLi, Changqing Jiang, Xuqian Lang, Ming Kong, Xiaojie Cheng, Ya Liu, Chao Feng*, Xiguang Chen*, Multilayer sodium alginate beads with porous core containing chitosan based nanoparticles for oral delivery of anticancer drug. International Journal of Biological Macromolecules, 2016, 85, 1-8. IF= 3.671, SCI二区

国家发明专利:

1.冯超、李静、陈西广、孔明、程晓杰、刘雅, 一种氨基聚糖修饰硅藻基止血粉的制备方法,国家发明专利、ZL201610494583.7

2.冯超、李静、陈西广、孔明、程晓杰、刘雅,一种金属阳离子修饰天然硅藻细胞膜止血粉的制备方法,国家发明专利、ZL201610732723.X

3.冯超、穆愈之、陈西广、孔明 、程晓杰、刘雅,一种具有黏液层渗透和P-gp抑制双重作用纳米胶束的制备方法,国家发明专利、ZL2016104945818

4.冯超、穆愈之、孔明、陈西广、程晓杰、刘雅,一种酶触响应性控释盐酸阿霉素的壳聚糖基复合纳米微粒的制备方法,国家发明专利、ZL201610646912.

5.冯超、李静、陈西广、孔明,一种羧甲基壳聚糖纳米微粒固定化多孔多层海藻酸钠胶球的制备方法,国家发明专利、ZL2016104555380

6.陈西广、冯超、程晓杰、孔明,一种具有pH敏感性的包载阿霉素的壳聚糖羧甲基壳聚糖纳米缓释微粒的制备方法、国家发明专利、ZL201210192675.

7.陈西广、冯超、程晓杰,一种羧甲基壳聚糖复合纳米胶囊的制备方法、国家发明专利、ZL201210101510.9

8.陈西广、冯超、程晓杰,一种壳寡糖复合纳米微粒的制备方法、国家发明专利、ZL201110376529.X

9.陈西广、冯超 、程晓杰,一种具有核壳结构的壳聚糖复合纳/微米胶囊的制备方法、国家发明专利、ZL201110325859.6

10.陈西广、冯超、程晓杰、孔明,一种壳聚糖复合纳米凝胶固定化多层胶囊的制备方法,国家发明专利、ZL201410037446.1