苏颖
博士，教授
电话：0532-82031916
地址：中国海洋大学鱼山校区达尔文馆219室
教育经历
1997.09-2001.07 清华大学，生物科学与技术系，学士
2001.09-2006.07 清华大学，生物科学与技术系，博士
工作经历
2006.10-2011.12 美国Cleveland Clinic, Lerner Research Institute, 博士后
2011.12-2014.09 美国Cleveland Clinic, Lerner Research Institute, Research Associate
2014.11-2015.12 美国布朗大学，Dept. MCB，Assistant Professor (Research)
2016.03-至今 中国海洋大学，海洋生命学院/海洋生物多样性与进化研究所，青年英才工程第一层次特聘教授
研究方向
动物胚胎发育过程中信号通路的转导机制及功能解析
利用斑马鱼和果蝇模式动物，针对 Hedgehog、Wnt、TGF等重要信号通路，开展新调控因子的筛选、鉴定、及相关作用机制的研究，相应的研究结果已在Cell、Science、Science Signaling、Development Cell、eLife、Cell Communication and Signaling等发育生物学领域的国际知名学术期刊上发表。
目前主要在研方向包括：
1）血细胞发育及谱系发生的调控机理；
2）蛋白质翻译后修饰在发育信号转导途径中的功能解析；
3）诱导细胞死亡的JNK信号通路的新调控因子的鉴定及相关机制研究。
代表性学术成果
*通讯作者/#共同一作
1. Chi C., Wang L., Lan W., Zhao L., Su Y.* (2018) PpV, acting via the JNK pathway, represses apoptosis during normal development of Drosophila wing. Apoptosisdoi: 10.1007/s10495-018-1479-2.
2. Zhao L., Wang L., Chi C., Lan W.,Su Y.* (2017) The emerging roles of phosphatases in Hedgehog pathway. Cell Communication and Signaling 15: 35.
3. Liu M., Li Y., Liu A., Li R., Su Y., Du J., Li C., Zhu A.J. (2016) The exon junction complex regulates the splicing of cell polarity gene dlg1 to control Wingless signaling in development.eLife5: e17200.
4. Du J., Zhang J., He T., Li Y., Su Y., Tie F., Liu M., Harte P., Zhu A.J. (2016) Stuxnet Facilitates the Degradation of Polycomb Protein during Development.Developmental Cell 37: 507-19.
5. Geisbrecht E. R., Sawant K., Su Y., Liu Z.C., Silver D.L., Burtscher A., Wang X., Zhu A.J., McDonald J.A. (2013) Genetic interaction screens identify a role for hedgehog signaling in Drosophila border cell migration. Developmental Dynamics 242: 414-31.
6. Zhang J., Liu M., Su Y., Du J., Zhu A.J. (2012) A targeted in vivo RNAi screen reveals deubiquitinases as new regulator of Notch signaling.G3: Genes, Genomes, Genetics 2: 1563-75.
7. Su Y., Ospina J.K., Zhang J., Michelson A., Schoen A.M., Zhu A.J. (2011) Sequential phosphorylation of Smoothened transduces graded Hedgehog signaling. Science Signaling 4: ra43.
8. Du J., Zhang J., Su Y., Liu M., Ospina J.K., Zhu A.J. (2011) in vivo RNAi Screen reveals neddylation genes as novel regulators of Hedgehog signaling. PLoS ONE 6: e24168.
9. Su Y., Zhang L., Gao X., Meng F., Wen J., Zhou H., Meng A., Chen Y. (2007) The evolutionally conserved activities of Dapper2 in antagonizing TGF- signaling. FASEB Journal 21: 682-90.
10. Lin X.#, Duan X.#, Liang Y.#, Su Y.#, Wrighton K.H., Long J., Hu M., Davis C.M., Wang J., Brunicardi F.C., Shi Y., Chen Y., Meng A., Feng X. (2006) PPM1A functions as a Smad phosphatase to terminate TGF signaling.Cell 125: 915-28.
11. Zhang L.#, Zhou H.#, Su Y.#, Sun Z., Zhang H., Zhang L., Zhang Y., Ning Y., Chen Y., Meng A. (2004) Zebrafish Dpr2 inhibits mesoderm induction by promoting degradation of Nodal receptors. Science306: 114-7.
12. Zhao C., Shi K., Su Y., Liang L., Yan Y., Postlethwait J., Meng A. (2003) Two variants of zebrafish p100 are expressed during embryogenesis and regulated by Nodal signaling. FEBS Letters 543: 190-5.
13. Zhao C., Zhang Y., Su Y., Meng A. (2002) Somite-specific expression of a novel fibronectin variant FN3 is negatively regulated by SHH. Chinese Science Bulletin47: 1807-11.
14. Sun Z., Shi K.,Su Y.,Meng A.(2002) A novel zinc finger transcription factor resembles krox-20 in structure and in expression pattern in zebrafish. Mechanisms of Development 114: 133-5.
15. Su Y.and Meng A. (2002) The expression of gbx-2 during zebrafish embryogenesis. Mechanisms of Development 113: 107-10.
16. Li M., Su Y., Meng A. (2002) Induction of cranial and posterior trunk neural crest by exogenous retinoic acid in zebrafish.Chinese Science Bulletin 47: 1105-8.
