秦贞奎，博士，副教授，博士生导师
邮箱：qinzk@ouc.edu.cn
承担课程：
本科生课程：《发育生物学》，《发育生物学实验》
研究生课程：《发育生物学与细胞分化》
学习工作经历：
2004.09~2008.06，中国海洋大学海洋生命学院，生物科学，学士
2008.09~2011.06，中国海洋大学海洋生命学院，海洋生物学，硕士
2011.08~2015.12，Auburn University, School of Fisheries, Aquaculture and Aquatic Sciences, Fisheries and Allied Aquaculture, Ph.D.
2013.01~2015.05，Auburn University, College of Sciences and Mathematics, Probability and Statistics, Master
2016.01~2017.12，中国海洋大学海洋生命学院，讲师
2018至今，中国海洋大学海洋生命学院，副教授
主要科研领域：
主要研究方向海洋动物生殖发育。以贝虾等海洋动物/水产经济动物为研究对象，通过遗传发育等多种技术手段对其生殖发育的分子调控机制进行解析；同时在海洋动物中开展基因编辑等新兴生物学技术的开发应用。
主持承担了国家自然科学基金面上项目、基金青年基金，山东省自然科学基金面上项目、青年基金等项目；作为课题骨干参与了国家重点研发计划、山东省自然科学基金重大基础研究项目，及其它市级校级项目等多项。
近年来在国内外主流学术刊物发表论文40余篇，主要研究成果以第一或通讯作者发表在Nature Ecology & Evolution, Aquaculture, Water Biology and Security, ACS Synthetic Biology, Aquaculture Reports等国际主流期刊；相关技术开发成果授权国家发明专利及美国发明专利多项。
学术兼职：
中科院二区SCI期刊BMC Genomics编委
招生专业：
海洋生物学，生物学，生物技术与工程
代表性成果：（#共同第一；*通讯作者）
一、发表论文：
1. Jing Wang#, Lingling Zhang#, Shanshan Lian#, ZhenkuiQin#, Xuan Zhu#, Xiaoting Dai, Zekun Huang, Caihuan Ke, Zunchun Zhou, Jiankai Wei, Pingping Liu, Naina Hu, Qifan Zeng, Bo Dong, Ying Dong, Dexu Kong, Zhifeng Zhang, Sinuo Liu, Yu Xia, Yangping Li, Liang Zhao, Qiang Xing, Xiaoting Huang, Xiaoli Hu, Zhenmin Bao, Shi Wang*. Evolutionary transcriptomics of metazoan biphasic life cycle supports a single intercalation origin of metazoan larvae. Nature Ecology & Evolution, 2020, 4: 725–736. （中科院小类一区TOP）
2. Xixi Li#, Ruiqi Zhang#, Yue Chen, Fang Liu, Xiyue Yang, Wenyuan Lai, Xiaoting Huang, Zhifeng Zhang, Zhenkui Qin*. Regulation of spermatogenesis by miR-375_1 via tuning the meiotic process in Chlamys farreri. Water Biology and Security, 2026. (中科院小类一区TOP)
3. Dawei Lin, Xixi Li, Zhifeng Zhang*, Zhenkui Qin*. Identification of sex determination region and development of sex-specific markers using genome re-sequencing in Urechis unicinctus (Annelida, Echiura). Aquaculture, 2026, 625, 744272. (中科院小类一区TOP)
4. Ying Lu#, Dawei Lin#, Shuai Zhou, Jiawang Cao, Xue Chen, Kai Liu, Zhifeng Zhang, Zhenkui Qin*, Jie Kong. Identification of cis-acting elements and trans-acting factors regulating the glycoprotein vitellogenin receptor: Unraveling the transcriptional regulatory network of vitellogenesis in the Pacific white shrimp Penaeus vannamei. International Journal of Biological Macromolecules, 2026, 352: 151069. (中科院小类二区TOP)
5. Xiaolin Guo#, Fang Liu#, Yue Chen, Shukun Dai, Qing Wang, Siyu Lin, Yifan Fu, Zhifeng Zhang, Zhenkui Qin*. Electroporation-mediated exogenous gene delivery methodology into germ cells of the scallop, Chlamys farreri. Aquaculture, 2026, 614: 743514. (中科院小类一区TOP)
6. Jianxiang Wang, Zhifeng Zhang, Xiaolin Guo, Fang Liu, Zhenkui Qin*, Xixi Li*. Investigating the role of miR-87a-3p_1 in regulating spermatogenesis in the scallop, Chlamys farreri. Aquaculture, 2025, 607: 742653. (中科院小类一区TOP)
7. Shutong Fan#, Xixi Li#, Xiaolin Guo, Ruiqi Zhang, Yue Chen, Feng Zhao, Lingling Zhang, Zhenkui Qin*, Zhifeng Zhang. Examination of the role of a novel transcription factor in activating Foxl2 and its potential involvement in the regulation of ovarian development in scallops. Aquaculture, 2023, 578, 740113.（中科院小类一区TOP）
8. De Xing, Mei Shang, Shangjia Li, Wenwen Wang, Tasnuba Hasin, Darshika Hettiarachchi, Veronica Alston, Logan Bern, Zhenkui Qin*, Baofeng Su*, Rex Dunham. CRISPR/Cas9-mediated precision integration of fat-1 and fat-2 from Caenorhabditis elegans at long repeated sequence in channel catfish (Ictalurus punctatus) and the impact on n-3 fatty acid level. Aquaculture, 2023, 567: 739229.（中科院小类一区TOP）
9. Xiaolin Guo, Xixi Li, Feng Zhao, Danwen Liu, Zujing Yang, Moli Li, Yajuan Li, Huilan Wei, Hao Wang, Zhenkui Qin*, Zhifeng Zhang, Zhenmin Bao. Full-length transcriptome analysis provides insights into larval shell formation in Mulinia lateralis. Frontiers in Marine Science, 2023, 9: 1111241.（中科院小类一区TOP）
10. De Xing, Baofeng Su, Max Bangs, Shangjia Li, Jinhai Wang, Logan Bern, Rhoda Mae C Simora, Wenwen Wang, Xiaoli Ma, Michael Coogan, Andrew Johnson, Yi Wang, Zhenkui Qin*, Rex Dunham*. CRISPR/Cas9 - mediated knock-in method can improve the expression and effect of transgene in P1 generation of channel catfish (Ictalurus punctatus). Aquaculture, 2022, 560: 738531.（中科院小类一区TOP）
11. Zhenkui Qin#, Aichang Ji#, Meng Yan, Danwen Liu, Xixi Li, XIaoli Hu*, Zhifeng Zhang*. Establishment of the first marine mollusk cell line from scallop (Chlamys farreri) trochophore. Aquaculture Reports, 2025, 40: 102626. （中科院小类一区）
12. De Xing, Shangjia Li, Mei Shang, Wenwen Wang, Qin Zhang, Jinhai Wang, Tasnuba Hasin, Darshika Hettiarachchi, Veronica Alston, Logan Bern, Abel Paladines Parrales, Cuiyu Lu, Michael Coogan, Andrew Johnson, Zhenkui Qin*, Baofeng Su*, Rex Dunham. A New Strategy for Increasing Knock-in Efficiency: Multiple Elongase and Desaturase Transgenes Knock-in by Targeting Long Repeated Sequences. ACS Synthetic Biology, 2022, 11: 4210-4219.（中科院小类一区）
13. De Xing, Baofeng Su, Shangjia Li, Max Bangs, David Creamer, Michael Coogan, Jinhai Wang, Rhoda Simora, Xiaoli Ma, Darshika Hettiarachchi, Veronica Alston, Wenwen Wang, Andrew Johnson, Cuiyu Lu, Tasnuba Hasin, Zhenkui Qin*, Rex Dunham*. CRISPR/Cas9 Mediated Transgenesis of the Masu Salmon (Oncorhynchus masou) elovl2 Gene Improves n 3 Fatty Acid Content in Channel Catfish (Ictalurus punctatus). Marine Biotechnology, 2022, 24: 513-523.（中科院小类二区）
14. Zhenkui Qin#, Yanjie Zhang#, Huawei Mu, Zhifeng Zhang*, Jian-Wen Qiu*. The sperm proteome of the echiuran Urechis unicinctus (Annelida, Echiura). Proteomics, 2018, 18: 1800107. （中科院小类二区）
15. Yajiao Bai, Di Zhou, Maokai Wei, Yueyang Xie, Beibei Gao, Zhenkui Qin*, Zhifeng Zhang*. Identification of Reference Genes for Normalizing Quantitative Real-Time PCR in Urechis unicinctus. Journal of Ocean University of China, 2018, 17: 614-622. （中科院小类二区）
二、授权专利：
1.秦贞奎，林思宇，张志峰，郭晓琳，李茜茜. 一种侏儒蛤卵子的电穿孔方法. （授权公号：CN2022103803266）
2. 秦贞奎, 王庆，张志峰，刘丹雯. 一种贝类精巢生精细胞解离和分离的方法.（授权公号：CN111534476B）
3. Rex A. Dunham, Zhenkui Qin, Guyu Qin. Gene Editing of Reproductive Hormones to Sterilize Aquatic Animals. （授权公号：US11140883B2）
4. 张志峰，李琦，魏茂凯，秦贞奎，卢丽. 一种单环刺螠幼虫的RNA干扰方法.（授权公号：CN110269014B）
5. 张志峰，李学玉，季爱昌，秦贞奎. 一种培养单环刺螠担轮幼虫细胞系的培养基及方法.（授权公号：CN105483075B）
