高瞻

发布者:杨光发布时间:2020-01-10浏览次数:3552

高瞻,男,博士,副教授,硕士生导师。

一、学习工作简历

2006.9-2010.6,中国海洋大学,生物科学专业,学士;

2010.9-2015.6,中国海洋大学,海洋生物学专业,博士;

2015.9-2018.12,中国海洋大学,海洋生命学院,讲师;

2019.1-至今,中国海洋大学,海洋生命学院,副教授。

二、研究方向

 比较免疫学,聚焦于文昌鱼免疫与进化。

三、科研项目

1. 国家自然科学基金青年项目“文昌鱼VCBP免疫识别和效应功能研究:VCBP类抗体功能探索”2017-2019已结题

2. 国家自然科学基金面上项目“垂体-甲状腺轴起源探索:文昌鱼促甲状腺素β亚基及其受体的相互作用和功能鉴定”,2018-2021,参加。

3. 国家自然科学基金面上项目“CRIP1在胚胎血管发育中的功能和作用机制研究”,2019-2022,参加。

四、代表性论著目录

(一)发表文章(*示通讯作者):

1.Gao Zhan, Qu Baozhen, Yao lan, Ma Zengyu, Zhang Shicui*. Identification andfunctional characterizationof amphioxus Miple,ancestral type ofvertebrate midkine/pleiotrophin homologues.Developmental & Comparative Immunology, 2018, 89:31-43.

2. Gao Zhan, Ma Zengyu, Qu Baozhen, Jiao Deyan, Zhang Shicui*. Identification and characterization ofproperdin in amphioxus: Implications for a functional alternative complement pathway in the basal chordate. Fish& Shellfish Immunology, 2017, 65:1-8.

3. Gao Zhan,Qu Baozhen, Ma Zengyu, Jiao Deyan, Ji Guangdong*, Zhang Shicui*. Identification andfunctional characterization of a novel member of lowdensity lipoprotein receptor-related protein (LRP)-likefamily in amphioxus. Gene, 2017, 618:42-48.

4.Gao Zhan, Li Mengyang, Ma Jie, Zhang Shicui*. An amphioxus gC1q protein binds human IgG and initiates the classical pathway: Implications for a C1q-mediated complement system in the basal chordate. European Journal of Immunology, 2014, 44(12): 3680-3695.

5.Gao Zhan, Li Mengyang, Wu Jie, Zhang Shicui*. Interplay between invertebrate C3a with vertebrate macrophages: Functional characterization of immune activities of amphioxus C3a. Fish & Shellfish Immunology, 2013, 35(4): 1249-1259.

6. Qu Baozhen, Ma Zengyu, Zhang Yu, Gao Zhan*, Zhang Shicui*. Characterization of a novel protein identified by proteomics analysis as a modulator of inflammatory networks in amphioxus.Fish &Shellfish Immunology, 2020, 96:97-106.

7. Yao Lan, Qu Baozhen, Ma Zengyu, Chen Ying, Tan Yunxia, Gao Zhan*, Zhang Shicui*. Lectin-like and bacterial-agglutinating activities of heat shock proteins Hsp5 and Hsp90α from amphioxus Branchiostoma japonicum.Fish &Shellfish Immunology, 2019, 95:688-696.

8. Ma Zengyu, Qu Baozhen, Zhong Shenjie, Yao Lan, Gao Zhan*, Zhang Shicui*. Subtle Difference Generates Big Dissimilarity: Comparison of Enzymatic Activity in KL1 and KL2 Domains of Lancelet Klotho.Marine Biotechnology (NY), 2019, 21(4):448-462.

9. Guo Xiaomin, Xin Jiajing, Wang Peng, Du Xiaoyuan, Ji Guangdong, Gao Zhan*, Zhang Shicui*.Functional characterization of avidins in amphioxus Branchiostoma japonicum: Evidence for a dual role in biotin-binding and immune response.Developmental & Comparative Immunology, 2017, 70: 106-118.

10. Qu Baozhen, Yang Shuangshuang, MaZengyu,Gao Zhan*, Zhang Shicui*. A new LDLa domain-containing C-type lectinwith bacterial agglutinatingand binding activity in amphioxus. Gene, 2016, 594(2): 220-228.

11. Li Mengyang, Gao Zhan, Ji Dongrui, Zhang Shicui*. Functional characterization of growth hormone (GH)-like homolog in amphioxus reveals an ancient origin of GH/GH receptor system. Endocrinology, 2014, 155(12): 4818-4830.

12. Li Mengyang, Gao Zhan, Wang Yu, Wang Hui, Zhang Shicui*. Identification, expression and bioactivity of hexokinase in amphioxus: Insights into evolution of vertebrate hexokinase genes. Gene, 2014, 535(2): 318-326.

13. Wang Yu, Wang Hui, Li Mengyang, Gao Zhan, Zhang Shicui*. Identification, expression and regulation of amphioxus G6Pase gene with an emphasis on origin of liver. General and Comparative Endocrinology, 2015. 214:9-16.

14. Wang Lixia, Wang Yuan, Li Zhaohe, Gao Zhan, Zhang Shicui*. Functional characterization of protein 4.1 homolog in amphioxus: Defining a cryptic spectrin-actin-binding site. Scientific Reports, 2013.3: 2873.

15. Sun Chen, Hu Lili, Liu Shousheng, Gao Zhan, Zhang Shicui*. Functional analysis of domain of unknown function (DUF) 1943, DUF1944 and von Willebrand factor type D domain (VWD) in vitellogenin2 in zebrafish.Developmental and Comparative Immunology, 2013. 41: 469-476.

(二)英文专著:

1.Gao Zhan,  Zhang Shicui*. Cephalochordata: Branchiostoma. In “Advances in Comparative Immunology”(Ed. by Edwin L. Cooper), 2018. Springer. Pages 593-636.

五、联系方式

 邮箱:gaozhan@ouc.edu.cn

 地址:中国海洋大学鱼山校区达尔文馆213