田华

发布者:杨光发布时间:2019-03-21浏览次数:4759

姓    名 : 田华,副教授,硕士生导师,博士

通讯地址 : 青岛市市南区鱼山路5号,中国海洋大学海洋生命学院 (266003)

电    话 0532-82031739 ()18561681668 (手机)

传    真 0532-82031962

电子邮件 tianhua@ouc.edu.cn, tianhua5521@163.com


主要研究方向与研究内容:

  1. 生态毒理学:环境内分泌干扰物的生物筛选方法与生物标志物研究;环境分泌干扰物的内分泌扰乱作用机制及其治理方法

  2. 生态规划与设计:生态市、生态县、生态乡镇规划;生态工业园区规划;循环经济与低碳发展规划


学历及学位

时 间

攻读学位

学   校

获奖及其他

2001.9-2005.7

生物技术学士

合肥工业大学生物与食品工程学院

学习优秀奖学金

2005.9-2007.7

生态学硕士

中国海洋大学海洋生命学院

学习优秀奖学金

2007.9-2010.7

生态学博士

中国海洋大学海洋生命学院

科技创新奖学金


主要研究经历

时 间

工作单位

职称

2010.7-至今

中国海洋大学海洋生命学院

讲师

2011.8-至今

中国海洋大学海洋生命学院

硕导

2013.1-至今

中国海洋大学海洋生命学院

副教授


以第一或通讯作者发表论文

  1.  Li X#, Wang Jun#, Yu M, Zhang X, Wang W, Tian H*, Ru S*.2,2-Dithiobis-pyridine induced reproductive toxicity in male guppy (Poecilia reticulata). Ecotoxicol Environ Saf, 2019, 169:778-785. (SCI二区, IF=3.974)

  2. Tian H, Li Y, Wang W, Zhao F, Gao S, Ru S*. Sexual characteristics of male guppies (Poecilia reticulataserve) as effect biomarkers of estrogens.Chin J Oceanol Limnol, 2018, 36(4):1392-1400. (SCI四区, IF=0.717)

  3. Tian H, Sun Y, Wang H, Bing X, Wang W, Ru S*. Monocrotophos pesticide affects synthesis and conversion of sex steroids through multiple targets in male goldfish (Carassius auratus).Sci Rep, 2017, 7(1):2306. (SCI三区, IF=4.122)

  4. Feng Y#, Chen Y#, Wang J, Gong Y, Liu X, Mu G, Tian H*. Ecological risk assessment of heavy metals in surfaceseawater and sediment near the outlet of a zinc factory inHuludao City, Liaoning Province, China. Chin J Oceanol Limnol, 2016, 34, 1320-1331. (SCI四区, IF=0.688)

  5. Tian H, Wu P, Wang W, Ru S*. Disruptions in aromatase expression in the brain, reproductive behavior, and secondary sexual characteristics in male guppies (Poecilia reticulata) induced by tributyltin.Aquat Toxicol, 2015, 162:117-125.(SCI一区, IF=3.557)

  6. Tian H, Li Y, Wang W, Wu P, Ru S*. Exposure to monocrotophos pesticide during sexual development causes the feminization/demasculinization of the reproductive traits and a reduction in the reproductive success of male guppies (Poecilia reticulata). Toxicol Appl Pharmacol, 2012, 263: 163-170. (SCI二区, IF=3.975)

  7. Pan Z#, Tian H#, Wang W, Wang J, Ru S*. Identification, purification, and immunoassay of stone flounder (Kareius bicolouratus) vitellogenin. J Korean Soc Appl Biol Chem, 2012, 55: 219-227. (SCI四区, IF=0.433, 同为第一作者)

  8. Tian H, Ru S*, Bing X, Wang W. Effects of monocrotophos on the reproductive axis in the male goldfish (Carassius auratus): potential mechanisms underlying vitellogenin induction. Aquat Toxicol, 2010, 98: 67-73. (SCI一区, IF=3.333)

  9. Tian H, Ru S*, Wang W, Bing X. Effects of monocrotophos on the reproductive axis in the female goldfish (Carassius auratus). Comp Biochem Physiol C Toxicol Pharmacol, 2010, 152: 107-113. (SCI四区, IF= 2.325)

  10. Tian H, Ru S*, Wang Z, Cai W, Wang W. Estrogenic effects of monocrotophos evaluated by vitellogenin mRNA and protein induction in male goldfish (Carassius auratus). Comp Biochem Physiol C Toxicol Pharmacol, 2009, 150: 231-236. (SCI四区, IF=2.582)

  11. 田华, 张旭, 汝少国, 张晓娜. 环境内分泌干扰物对硬骨鱼类甲状腺轴的干扰作用研究进展. 渔业科学进展, 2017, 38(4): 186-191.

  12. 孙娜, 田华*, 王蔚, 汝少国. 重金属对秀丽隐杆线虫繁殖的影响. 环境科学研究, 2016, 29: 716-723.

  13. 田华, 汝少国, 邴欣. 环境激素对鱼类内分泌轴线的干扰作用及其机制研究进展. 安全与环境学报, 2009, 9: 10-14.


以共同作者发表论文

  1. Wang W, Zhang X*, Wang Z, Qin J, Wang W, Tian H, Ru S*. Bisphenol S induces obesogenic effects through deregulating lipid metabolism in zebrafish (Danio rerio) larvae.Chemosphere, 2018, 199: 286-296.(SCI二区, IF=4.427)

  2. Liu W, Zhang X, Wei P, Tian H, Wang W, Ru S*. Long-term exposure to bisphenol S damages the visual system and reduces the tracking capability of male zebrafish (Danio rerio).J Appl Toxicol, 2018, 38: 248-258. (SCI三区, IF=2.909)

  3. Zhang X, Liu W, Wang J, Tian H, Wang W, Ru S*. Quantitative analysis of in-vivo responses of reproductive and thyroid endpoints in male goldfish exposed to monocrotophos pesticide.Comp Biochem Physiol C Toxicol Pharmacol, 2018, 211: 41-47. (SCI二区, IF=2.426)

  4. Yue Z#, Yu M#, Zhao H, Wang J, Zhang X, Tian H, Wang W, Ru S*.The anti-estrogenicity of chronic exposure to semicarbazide in female Japanese flounders (Paralichthys olivaceus), and its potential mechanisms. Mar Pollut Bull, 2018, 129: 806-812. (SCI一区, IF=3.241)

  5. Gong Y, Tian H, Dong Y, Zhang X, Wang W*, Ru S*.An in vivo assay performed using multiple biomarkers related to testosterone synthesis and conversion for assessing the androgenic potency of refuse leachate.Ecotoxicol Environ Saf, 2017, 135:82-89. (SCI二区, IF=3.974)

  6. Zhang X, Xu L, Tian H, Wang C, Wang W, Ru S*.Monocrotophos, an organophosphorus insecticide, disrupts the expression of HpNetrin and its receptor neogenin during early development in the sea urchin (Hemicentrotus pulcherrimus).Neurotoxicology, 2017, 62:130-137. (SCI二区, IF=3.100)

  7. Dong Y#, Zhang X#, Tian H, Li X, Wang W, Ru S*. Effects of polychlorinated biphenyls on metamorphosis of a marine fish Japanese flounder (Paralichthys olivaceus) in relation to thyroid disruption. Mar Pollut Bull, 2017, 119: 325-331. (SCI一区, IF=3.146)

  8. Wang J, Wang W, Tian H, Zhang X, Ru S*.A novel enzyme-linked immunosorbent assay based on anti-lipovitellin monoclonal antibodies for quantification of zebrafish (Danio rerio) vitellogenin.Ecotoxicol Environ Saf, 2017, 136:78-83. (SCI二区, IF=3.974)

  9. Zhang X, Li S, Wang C, Tian H, Wang W, Ru S*.Effects of monocrotophos pesticide on cholinergic and dopaminergic neurotransmitter systems during early development in the sea urchin Hemicentrotus pulcherrimus.Toxicol Appl Pharmacol, 2017, 328:46-53.(SCI二区, IF=3.791)

  10. Yue Z, Yu M, Zhang X, Dong Y, Tian H, Wang W, Ru S*.Semicarbazide-induced thyroid disruption in Japanese flounder (Paralichthys olivaceus) and its potential mechanisms.Ecotoxicol Environ Saf, 2017, 140:131-140. (SCI, IF=3.974)

  11. Yu M, Feng Y, Zhang X, Wang J, Tian H, Wang W, Ru S*.Semicarbazide disturbs the reproductive system of male zebrafish (Danio rerio) through the GABAergic system.Reprod Toxicol, 2017, 73:149-157.(SCI三区, IF=2.341)

  12. Zhao F, Wei P, Wang J, Yu M, Zhang X, Tian H, Wang W, Ru S*. Estrogenic effects associated with bisphenol a exposure in male zebrafish (Danio rerio) is associated with changes of endogenous 17β-estradiol and gene specific DNA methylation levels. Gen Comp Endocrinol, 2017, 52:27-35. (SCI四区, IF=2.585)

  13. Gong Y, Tian H, Dong Y, Zhang X, Wang J, Wang W*, Ru S*.Thyroid disruption in male goldfish (Carassius auratus) exposed to leachate from a municipal waste treatment plant: Assessment combining chemical analysis and in vivo bioassay.Sci Total Environ, 2016, 554-555:64-72. (SCI二区, IF= 4.900)

  14. Gong Y, Tian H, Zhang X, Dong Y, Wang W, Ru S*.Refuse leachate exposure causes changes of thyroid hormone level and related gene expression in female goldfish (Carassius auratus).Environ Toxicol Pharmacol, 2016, 48:46-52. (SCI三区, IF=2.313)

  15. Yu M, Zhang X, Guo L, Tian H, Wang W, Ru S*.Anti-estrogenic effect of semicarbazide in female zebrafish (Danio rerio) and its potential mechanisms.Aquat Toxicol, 2016, 170:262-270. (SCI一区, IF=4.129)

  16. Wang J, Zhao F, Shan R, Tian H, Wang W*, Ru S*.Juvenile zebrafish in the vitellogenin blank period as an alternative test organism for evaluation of estrogenic activity of chemicals.Environ Toxicol Chem. 2016, 35(7):1783-1787. (SCI三区, IF= 2.951)

  17. Wang J, Zhang X, Shan R, Ma S, Tian H, Wang W, Ru S*.Lipovitellin as an antigen to improve the precision of sandwich ELISA for quantifying zebrafish (Danio rerio) vitellogenin.Comp Biochem Physiol C Toxicol Pharmacol, 2016, 185-186:87-93.(SCI三区, IF= 2.416)

  18. Zhang X, Zhong Y, Tian H, Wang W, Ru S*.Impairment of the cortisol stress response mediated by thehypothalamus–pituitary–interrenal (HPI) axis in zebrafish(Danio rerio) exposed to monocrotophos pesticide. Comp Biochem Physiol C Toxicol Pharmacol, 2015, 176-177: 10-16. (SCI三区, IF= 2.546)

  19. Zhao F, Wang B, Zhang X, Tian H, Wang W, Ru S*. Induction of DNA base damage and strand breaksin peripheral erythrocytes and the underlying mechanismin goldfish (Carassius auratus) exposed to monocrotophos. Fish Physiol Biochem, 2015, 41(3): 613-624. (SCI四区, IF= 1.442)

  20. Wang Z, Zhang X, Tian H, Wang W, Ru S*. Effects of monocrotophos pesticide on steroidogenesis and transcription of steroidogenic enzymes in rainbow trout RTG-2 cells involving the protein kinase A signal pathway. Toxicol In Vitro, 2015, 29: 155-161. (SCI三区, IF=3.338)

  21. Wang J, Bing X, Yu K, Tian H, Wang W*, Ru S*. Preparation of a polyclonal antibody against goldfish (Carassius auratus) vitellogenin and its application to detect the estrogenic effects of monocrotophos pesticide. Ecotoxicol Environ Saf, 2015, 111: 109-116. (SCI二区, IF=3.130)

  22. Wang J, Shan R, Zhang X, Tian H, Wang W*, Ru S*.Development of a lipovitellin-based sandwich ELISA for quantification of vitellogenin in surface mucus and plasma of goldfish (Carassius auratus).Ecotoxicol Environ Saf, 2015, 120:80-87. (SCI二区, IF=3.130)

  23. Wang J, Wang W, Zhang X, Tian H, Ru S*.Development of a lipovitellin-based goldfish (Carassius auratus) vitellogenin ELISA for detection of environmental estrogens.Chemosphere, 2015, 132:166-171. (SCI二区, IF= 3.698)

  24. Gong Y, Tian H, Wang L, Yu S, Ru S*. An integrated approach combining chemical analysis and an in vivo bioassay to assess the estrogenic potency of a municipal solid waste landfill leachate in Qingdao. PLoS One, 2014, 9: e95597. (SCI二区, IF=3.234)

  25. Dong Y, Tian H, Wang W, Zhang X, Liu J, Ru S*. Disruption of the thyroid system by the thyroid-disrupting compound Aroclor 1254 in juvenile Japanese flounder (Paralichthys olivaceus). PLoS One, 2014, 9: e104196. (SCI二区, IF=3.234)

  26. Zhang X, Tian H, Wang W, Ru S*. Monocrotophos pesticide decreases the plasma levels of total 3,3,5-triiodo-L-thyronine and alters the expression of genes associated with the thyroidal axis in female goldfish (Carassius auratus). PLoS One, 2014, 9: e108972. (SCI二区, IF=3.234)

  27. Wang Z, Sun M, Tian H, Gao S, WangW, Ru S*. Estrogenic effects of monocrotophos standard on male goldfish, Carassius auratus: induction of vitellogenin synthesis and alteration of testicular ultrastructure and function. Anim Biol, 2014, 64: 311-331. (SCI四区, IF=0.597)

  28. Gao S, Wang W*, Tian H, Zhang X, Guo L, Ru S. An emerging water contaminant, semicarbazide, exerts an anti-estrogenic effect in zebrafish (Danio rerio). Bull Environ Contam Toxicol, 2014, 93(3):280-288. (SCI四区, IF=1.255)

  29. Zhang X, Tian H, Wang W, Ru S*.Exposure to monocrotophos pesticide causes disruption of the hypothalamus-pituitary-thyroid axis in adult male goldfish (Carassius auratus). Gen Comp Endocrinol, 2013,193: 158-166. (SCI三区, IF=2.674)

  30. Xu L, Tian H, Wang W, Ru S*. Effects of monocrotophos pesticide on serotonin metabolism during early development in the sea urchin, Hemicentrotus pulcherrimus. Environ Toxicol Pharmacol, 2012, 34(2): 537-547. (SCI三区, IF=2.005)

  31. Zhang X, Gao L, Yang K, Tian H, Wang W, Ru S*. Monocrotophos pesticide modulates the expression of sexual differentiation genes and causes phenotypic feminization in zebrafish (Danio rerio).Comp Biochem Physiol C Toxicol Pharmacol, 2012, 157(1): 33-40. (SCI四区, IF=2.707)

  32. 王慧, 田华, 汝少国*. EEDs对鱼类性激素合成途径干扰作用的研究进展. 生态毒理学报, 2013, 8(3): 23-30.

  33. 汝少国, 潘宗保, 田华. 鱼类卵黄原蛋白研究进展. 海洋湖沼通报, 2012, 2: 22-32.

  34. 高蕾, 田华, 汝少国. 环境内分泌干扰物对鱼类性别分化影响的研究进展. 生态毒理学报. 2012, 6: 593-602.

  35. 张晓娜, 田华, 汝少国. 鱼类甲状腺轴对胚胎发育、仔鱼变态及性别分化的调控作用研究进展. 中国海洋大学学报(自然科学版), 2012, 42(Sup.): 94-101.

  36. 李长安, 王蔚, 田华, 汝少国. 林丹对细小色矛线虫的行为毒性研究. 中国海洋大学学报(自然科学版), 2011, 41(Sup.): 199-202.

  37. 孙萌, 邴欣, 姜明, 田华. 久效磷对雄性金鱼分泌细胞超微结构的影响. 海洋湖沼通报, 2010, 1: 95-70.

  38. 尹德玉, 汝少国, 田华. 环境内分泌干扰物对鱼类性别决定的影响研究进展. 生态毒理学报, 2009, 4: 581-588.

  39. 姜雪, 汝少国, 田华. 内分泌扰乱化学物质对斑马鱼生长发育影响研究进展. 科技导报, 2009, 26: 94-98.


专利

  1. 汝少国, 王军, 王蔚, 田华. 斑马鱼卵黄原蛋白免疫印迹试剂盒及其检测方法与应用, 中华人民共和国国家知识产权局, 专利号: ZL 201410748506.0

  2. 汝少国, 王军, 王蔚, 田华. 斑马鱼卵黄原蛋白间接竞争ELISA试剂盒及其检测方法与应用, 中华人民共和国国家知识产权局, 专利号: ZL 201410752194.0

  3. 汝少国, 王军, 王蔚, 田华. 斑马鱼卵黄原蛋白夹心ELISA试剂盒及其检测方法与应用, 中华人民共和国国家知识产权局, 专利号: ZL 201410748510.7

  4. 汝少国, 王军, 王蔚, 田华. 定性检测鲤科鱼类卵黄脂磷蛋白的试剂盒及其应用, 中华人民共和国国家知识产权局, 专利号: ZL201210557080.1, 20141022.

  5. 汝少国, 王军, 王蔚, 田华. 利用卵黄脂磷蛋白抗体定性检测鱼类卵黄原蛋白的试剂盒, 中华人民共和国国家知识产权局, 专利号: ZL201210559592.1, 20141022.


编著书情况

    1. 田华,辛蕾编著.《话说中国海洋生态保护》, 广东经济出版社, 2014.


主持或参与科研课题

  1. 田华.国家自然科学基金面上项目2,2'-二硫二吡啶通过甲状腺干扰效应导致褐牙鲆变态延迟的分子机制研究(编号:41876121), 2019-2022.

  2. 汝少国等. 国家自然科学基金面上项目新型海洋污染物氨基脲对褐牙鲆的抗雌激素效应机制研究(编号:41676100), 2017-2020.

  3. 田华. 国家自然科学基金青年基金基于下丘脑-垂体-甲状腺-肝脏轴探讨多氯联苯影响牙鲆变态的机制(编号:31202001), 2013-2015.

  4. 田华. 山东省自然科学基金青年基金多氯联苯影响牙鲆变态的甲状腺干扰机制研究(编号:ZR2012CQ010), 2012-2015.

  5. 田华. 浙江省科技厅项目滩涂围垦对河口海岸环境和生态影响研究创新团队建设项目专题合作研究, 2010-2012.

  6. 杨红生. 海洋公益科研专项经费项目典型海湾受损生境修复生态工程和效果评价技术集成与示范(编号:2013418043), 2013-2016.

  7. 马启敏. 海洋公益科研专项经费项目海洋溢油污染风险评估及应急响应关键技术集成及应用示范(编号:201205012), 2012-2015.

  8. 邴欣, 汝少国等. 山东省自然科学基金青年基金“久效磷对雄性真鲷下丘脑垂体性腺轴的干扰作用研究(编号:Q2007E01), 2007-2010.

  9. 汝少国, 党志超等. 国家自然科学基金青年基金“久效磷对鱼类环境雌激素效应的生物标记物研究”(编号:30200211), 2003-2005.


参与横向课题

  1. 汝少国. 青岛经济技术开发区(黄岛区)国家生态工业示范园区建设规划, 2011.

  2. 汝少国. 青岛市市南区循环经济发展规划, 2008.

  3. 汝少国. 即墨市循环经济发展规划, 2007.

  4. 汝少国. 临沂市河东区生态区发展规划, 2006.

  5. 汝少国. 鲁洲生物科技有限公司循环经济规划, 2006.

  6. 汝少国. 临沂市鲁南MALL财富广场项目环境影响评价报告书, 2006.

  7. 汝少国. 临沂市沂水天然地下画廊旅游区项目环境影响评价报告书, 2006.


学术会议

  1.  2017.10.19-2017.10.22, 第九届全国环境化学大会, 口头报告久效磷农药通过多个靶点影响雄性金鱼性激素合成与转化, 杭州.

  2.  2017.6.10, 第二届秀丽线虫毒理学学术研讨会, 口头报告以线虫为模式生物的有机磷和有机氯农药毒性效应研究, 南京.

  3.  2016.10.22, 首届秀丽线虫毒理学学术研讨会, 南京.

  4.  2015.4.25-2015.4.28, 第二届生态毒理学学术研讨会.口头报告以线虫为模式生物的有机磷和有机氯农药毒性效应研究, 厦门.

  5.  2014.8.22-2014.8.23, 中国环境科学学会2014年学会年会, 中国环境科学学会, 成都.

  6.  2013.10.18-2013.10.21, 中国生态学学会2013年学术年会, 中国生态学学会. 口头报告久效磷农药的环境雌激素效应及其作用机制研究, 南昌.

  7.  2012.7.13-2012.7.14, 青岛-桃园 第一届两岸斑马鱼学术研讨会, 青岛.

  8.  2010.11.10-2010.11.12, 第一届分子医学大会, 上海.

  9.  2010.6.19-2010.06.20, 第四届中国生物产业大会, 济南.

  10.  2007.9.5-2007.9.6, 持久性有机污染物监测与防治技术交流研讨会, 中国环境科学学会, 广州.


获奖情况

  1.  20189月,科研成果大豆异黄酮影响罗非鱼生长的神经内分泌调控机理研究2018年山东省高等学校优秀科研成果奖一等奖。(本人为第三位)

  2.  20133月,指导青岛一中学生范舒睿的项目脱硫海水排放对附近海域海水水质的影响,获得第28届青岛市青少年科技创新大赛青少年科技创新成果 一等奖。(本人为第二指导教师)

  3.  20126月,指导本科生韩艳艳的毕业论文“金鱼(Carassius auratus)卵巢17β-羟类固醇脱氢酶I基因片段克隆”,获中国海洋大学校级优秀本科毕业论文。

  4.  20116月,指导本科生杨崇的毕业论文久效磷农药对新吉富品系尼罗罗非鱼(Oreochromis niloticus)生长发育的影响,获中国海洋大学校级优秀本科毕业论文。

  5.  20114月,博士毕业论文久效磷对金鱼生殖轴线的影响研究,获中国海洋大学第十一届优秀博士论文奖二等奖。

  6.  20109月,博士期间科研成果久效磷农药对金鱼的环境雌激素效应及其机制,获山东省2010年研究生优秀科技创新成果三等奖。

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