张玉忠

发布者:杨光发布时间:2023-02-27浏览次数:9452

姓名 张玉忠

职称: 教授、博士生导师

职务:海洋生命学院 院长

电话:0532-58632578

邮箱:zhangyuzhong6830@ouc.edu.cn

教育背景

博士 起止时间:1992.09-1995.08毕业院校:中国科学院海洋研究所 专业:海洋生物学

硕士 起止时间:1989.09-1992.06毕业院校:南京农业大学 专业:农学

学士 起止时间:1985.09-1989.06毕业院校:山东师范大学 专业:生物学

工作经历

1995.09-1998.05  山东大学微生物技术国家实验室       博士后

1998.06-2000.08  山东大学微生物技术国家实验室       副教授

2000.09-至今     山东大学微生物技术国家实验室      教授、特聘教授

2001.09-至今     山东大学微生物技术国家实验室      博士生导师

2017.12-至今     中国海洋大学海洋生命学院        “筑峰人才工程”第一层次特聘教授

研究方向

海洋微生物科学与技术、海洋微生物生态学与微生物海洋学

主要研究内容:

1)海洋微生物资源分类与系统进化;

2)海洋极端微生物独特的生命特征与环境适应机制及结构基础;

3)海洋微生物酶的结构与功能及其驱动有机碳、氮、磷、硫生物地球化学循环过程与分子机制;

4)海洋微生物资源开发与利用技术。

科研项目

主持承担多项国家自然科学基金重点类项目、国家重点研发计划项目/课题、山东省重大创新工程等重大、重点项目,研究经费充足。

代表性论文

  1. Qi Sheng, Meng-Yao Zhang, Si-Min Liu, Zhuo-Wei Chen, Pei-Ling Yang, Hong-Su Zhang, Meng-Yun Liu, Kang Li, Long-Sheng Zhao, Ning-Hua Liu, Lu-Ning Liu, Xiu-Lan Chen, Jamie K Hobbs, Simon J Foster*, Yu-Zhong Zhang*, Hai-Nan Su*. In situ visualization of Braun's lipoprotein on E. coli sacculi. Sci Adv. 2023 Jan 20; 9(3): eadd8659.

  2. Chun-Yang Li, Michaela A Mausz, Andrew Murphy, Nan Zhang, Xiu-Lan Chen, Shu-Yan Wang, Chao Gao, María M Aguilo-Ferretjans, Eleonora Silvano, Ian D E A Lidbury, Hui-Hui Fu, Jonathan D Todd, Yin Chen*, Yu-Zhong Zhang.* Ubiquitous occurrence of a dimethylsulfoniopropionate ABC transporter in abundant marine bacteria, ISME J, 2023 Jan 27. doi: 10.1038/s41396-023-01375-3.

  3. Yang Yu, Peng Wang, Hai-Yan Cao, Zhao-Jie Teng, Yanping Zhu, Min Wang, Andrew McMinn, Yin Chen, Hua Xiang, Yu-Zhong Zhang*, Xiu-Lan Chen*, Yu-Qiang Zhang*. Novel D-glutamate catabolic pathway in marine Proteobacteria and halophilic archaea. ISME J.2023 Jan 23. doi: 10.1038/s41396-023-01364-6.

  4. Ming Peng, Chun-Yang Li, Xiu-Lan Chen, Beth T Williams, Kang Li, Ya-Nan Gao, Peng Wang, Ning Wang, Chao Gao, Shan Zhang, Marie C Schoelmerich, Jillian F Banfield, J Benjamin Miller, Nick E Le Brun, Jonathan D Todd*, Yu-Zhong Zhang*. Insights into methionine S-methylation in diverse organisms, Nat Commun. 2022, 13(1): 2947.

  5. Wen-Xin Jiang, Ping-Yi Li*, Xiu-Lan Chen, Yi-Shuo Zhang, Jing-Ping Wang, Yan-Jun Wang, Qi Sheng, Zhong-Zhi Sun, Qi-Long Qin, Xue-Bing Ren, Peng Wang, Xiao-Yan Song, Yin Chen, Yu-Zhong Zhang*. A pathway for chitin oxidation in marine bacteria.Nat Commun. 2022 Oct 6;13(1): 5899.

  6. Yan Wang, Peng Wang, Hai-Yan Cao, Hai-Tao Ding, Hai-Nan Su, Shi-Cheng Liu, Guangfeng Liu, Xia Zhang, Chun-Yang, Ming Peng, Fuchuan Li, Shengying, Yin Chen, Xiu-Lan Chen*, Yu-Zhong Zhang*. Structure of Vibrio collagenase VhaC provides insight into the mechanism of bacterial collagenolysis. Nat Commun. 2022, 13(1):566.

  7. Zhao-Jie Teng, Peng Wang, Xiu-Lan Chen, Richard Guillonneau, Chun-Yang Li, Song-Bao Zou, Jun Gong, Kai-Wen Xu, Lin Han, Chao Wang, David J Scanlan, Yin Chen, Yu-Zhong Zhang*, Acrylate protects a marine bacterium from grazing by a ciliate predator, Nat Microbiol. 2021, 6(11): 1351-1356.

  8. Qi-Long Qin, Zhi-Bin Wang, Hai-Nan Su, Xiu-Lan Chen, Jie Miao, Xiu-Juan Wang, Chun-Yang Li, Xi-Ying Zhang, Ping-Yi Li, Min Wang, Jiasong Fang, Ian Lidbury, Weipeng Zhang, Xiao-Hua Zhang, Gui-Peng Yang, Yin Chen, Yu-Zhong Zhang*. Oxidation of trimethylamine to trimethylamine N-oxide facilitates high hydrostatic pressure tolerance in a generalist bacterial lineage. Sci Adv. 2021 Mar 26; 7(13): eabf9941.

  9. Chun-Yang Li, Xiu-Juan Wang, Xiu-Lan Chen, Qi Sheng, Shan Zhang, Peng Wang, Mussa Quareshy, Branko Rihtman, Xuan Shao, Chao Gao, Fuchuan Li, Shengying Li, Weipeng Zhang, Xiao-Hua Zhang, Gui-Peng Yang, Jonathan D Todd, Yin Chen, Yu-Zhong Zhang*, A novel ATP dependent dimethylsulfoniopropionate lyase in bacteria that releases dimethyl sulfide and acryloyl-CoA, Elife, 2021, 10: e64045.

  10. Qingdong Zhang , Hai-Yan CaoLin WeiDanrong LuMin DuMin YuanDeling ShiXiangxue ChenPeng WangXiu-Lan ChenLianli ChiYu-Zhong Zhang*, Fuchuan Li*, Discovery of exolytic heparinases and their catalytic mechanism and potential application, Nat Commun. 2021, 12(1): 1263.

  11. Bin-Bin XieJin-Cheng RongBai-Lu TangSishuo WangGuiming LiuQi-Long QinXi-Ying Zhang  1 Weipeng ZhangQunxin SheYin ChenFuchuan LiShengying LiXiu-Lan ChenHaiwei Luo*, Yu-Zhong Zhang*, Evolutionary Trajectory of the Replication Mode of Bacterial Replicons, mBio. 2021, 12(1): e02745-20.

  12. Ning WangXiu-Lan ChenChao GaoMing PengPeng WangNa ZhangFuchuan LiGui-Peng Yang , Qing-Tao ShenShengying LiYin ChenYu-Zhong ZhangChun-Yang Li*, Crystal structures of γ-glutamylmethylamide synthetase provide insight into bacterial metabolism of oceanic monomethylamine, J Biol Chem. 2020, 296: 100081.

  13. Fei XuXiu-Lan ChenXiao-Hui SunFang DongChun-Yang LiPing-Yi LiHaitao DingYin ChenYu-Zhong ZhangPeng Wang*, Structural and molecular basis for the substrate positioning mechanism of a new PL7 subfamily alginate lyase from the arctic, J Biol Chem. 2020, 295(48): 16380-16392.

  14. Yue WangPing-Yi LiYi ZhangHai-Yan CaoYan-Jun WangChun-Yang LiPeng WangHai-Nan SuYin ChenXiu-Lan Chen*, Yu-Zhong Zhang*,  6-Anhydro-L-Galactose Dehydrogenase VvAHGD is a Member of a New Aldehyde Dehydrogenase Family and Catalyzes by a Novel Mechanism with Conformational Switch of Two Catalytic Residues Cysteine 282 and Glutamate 248, J Mol Biol. 2020, 432(7): 2186-2203.

  15. Bai-Lu Tang, Jie Yang, Xiu-Lan Chen, Peng Wang, Hui-Lin Zhao, Hai-Nan Su, Chun-Yang Li, Yang Yu, Shuai Zhong, Lei Wang, Ian Lidbury, Haitao Ding, Min Wang, Andrew McMinn, Xi-Ying Zhang, Yin Chen & Yu-Zhong Zhang*, A predator-prey interaction between a marine Pseudoalteromonas sp. and Gram-positive bacteria, Nat Commun. 2020, 11(1):285.

  16. Long-Sheng Zhao, Tuomas Huokko, Sam Wilson, Deborah M Simpson, Qiang Wang, Alexander V Ruban, Conrad W Mullineaux, Yu-Zhong Zhang*, Lu-Ning Liu*, Structural variability, coordination and adaptation of a native photosynthetic machinery, Nature Plants.2020. 6(7):869-882.

  17. Yue Wang, Ping-Yi Li, Yi Zhang, Hai-Yan Cao, Yan-Jun Wang, Chun-Yang Li, Peng Wang, Hai-Nan Su, Yin Chen, Xiu-Lan Chen*, Yu-Zhong Zhang*, 3,6-Anhydro-L-Galactose Dehydrogenase VvAHGD is a Member of a New Aldehyde Dehydrogenase Family and Catalyzes by a Novel Mechanism with Conformational Switch of Two Catalytic Residues Cysteine 282 and Glutamate 248, J Mol Biol.2020, 432(7):2186-2203.

  18. Qi-Long Qin, Yi Li, Lin-Lin Sun, Zhi-Bin Wang, Shi Wang, Xiu-Lan Chen, Aharon Oren*, Yu-Zhong Zhang*, Trophic specialization results in genomic reduction in free-living marine Idiomarina bacteria. mBio. 2019, 15, 10:e02545-18.

  19. Xuan Shao, Hai-Yan Cao, Fang Zhao, Peng Ming, Peng Wang, Chun-Yang Li, Wei-Ling Shi, Tian-Di Wei, Zenglin Yuan, Xiu-Lan Chen, Jonathan D. Todd and Yu-Zhong Zhang*Mechanistic insight into 3-methylmercaptopropionate metabolism and kinetical regulation of demethylation pathway in marine dimethylsulfoniopropionate-catabolizing bacteria. Mol Microbiol. 2019, 111(4):1057–1073.

  20. Fang Dong, Fei Xu, Xiu-Lan Chen, Ping-Yi Li, Chun-Yang Li, Fu-chuan Li, Yin Chen, Peng Wang*, Yu-Zhong Zhang*,Alginate lyase Aly36B is a new bacterial member of the polysaccharide lyase family 36 and catalyzes by a novel mechanism with lysine as both the catalytic base and catalytic acid. Journal of Molecular Biology.2019, 431(24):4897-4909.

  21. Chun-Yang Li, Xiu-Lan Chen, Dian Zhang, Peng Wang, Qi Sheng, Ming Peng, Bin-Bin Xie, Qi-Long Qin, Ping-Yi Li, Xi-Ying Zhang, Hai-Nan Su, Xiao-Yan Song, Mei Shi, Bai-Cheng Zhou, Lu-Ying Xun, Yin Chen, Yu-Zhong Zhang*, Structural mechanism for bacterial oxidation of oceanic trimethylamine into trimethylamine N-oxide. Molecular Microbiology. 2017, 103(6): 992–1003.

  22. Fei Xu, Fang Dong, Peng Wang, Hai-Yan Cao, Chun-Yang Li, Ping-Yi Li, Xiu-Hua Pang, Yu-Zhong Zhang, Xiu-Lan Chen*, Novel Molecular Insights into the Catalytic Mechanism of Marine Bacterial Alginate Lyase AlyGC from Polysaccharide Lyase Family 6. J Biol Chem. 2017, 292: 4457-4468.

  23. Chun-Yang Li#, Dian Zhang#, Xiu-Lan Chen, Peng Wang, Wei-Ling Shi, Ping-Yi Li, Xi-Ying Zhang, Qi-Long Qin, Jonathan D. Todd, Yu-Zhong Zhang*, Mechanistic Insights into Dimethylsulfoniopropionate Lyase DddY, a New Member of the Cupin Superfamily. Journal of Molecular Biology. 2017, 429: 3850-3862.

  24. Peng Wang#, Hai-Yan Cao#, Xiu-Lan Chen, Chun-Yang Li, Ping-Yi Li, Xi-Ying Zhang, Qi-Long Qin, Jonathan D. Todd, Yu-Zhong Zhang*, Mechanistic insight into acrylate metabolism and detoxification in marine dimethylsulfoniopropionate-catabolizing bacteria. Molecular Microbiology. 2017, 105(5), 674–688.

  25. Yu-Zhong Zhang, Yi Li, Bin-Bin Xie, Xiu-Lan Chen, Qiong-Qiong Yao, Xi-Ying Zhang, Megan L. Kempher, Jizhong Zhou, Aharon Oren, Qi-Long Qin* (2016) Nascent Genomic Evolution and Allopatric Speciation of Myroides profundi D25 in Its Transition from Land to Ocean. mBio. 7(1): e01946-15.

  26. Ang Liu, Yang Yu, Qi Sheng, Xiao-Yu Zheng, Jin-Yu Yang, Ping-Yi Li, Mei Shi, Bai-Cheng Zhou, Yu-Zhong Zhang, Xiu-Lan Chen*2016Identification of four kinds of 2′, 3′-cNMPs in Escherichia coli and a simple and efficient method for their simultaneous preparation. ACS Chemical Biology. 11: 2414-2419.

  27. Zi-Chao Yu, Xiu-Lan Chen, Qing-Tao Shen, Dian-Li Zhao, Bai-Lu Tang, Hai-Nan Su, Zhao-Yu Wu, Qi-Long Qin, Bin-Bin Xie, Xi-Ying Zhang, Yong Yu, Bai-Cheng Zhou, Bo Chen and Yu-Zhong Zhang*, Filamentous phages prevalent in Pseudoalteromonas spp. confer properties advantageous to host survival in Arctic sea ice, ISME Journal.2015, 9(4):871-81.

  28. Peng Wang, Xiu-Lan Chen, Chun-Yang Li, Xiang Gao, Deyu Zhu, Bin-Bin Xie, Qi-Long Qin, Xi-Ying Zhang, Hai-Nan Su, Bai-Cheng Zhou, Luying Xun and Yu-Zhong Zhang*. Structural and molecular basis for the novel catalytic mechanism and evolution of DddP, an abundant peptidase-like bacterial Dimethylsulfoniopropionate lyase: a new enzyme from an old fold. Molecular Microbiology. 2015, 98(2): 289-301.

  29. Ping-Yi Li, Xiu-Lan Chen, Peng Ji, Chun-Yang Li, Peng Wang, Yi Zhang, Bin-Bin Xie, Qi-Long Qin, Hai-Nan Su, Bai-Cheng Zhou, Yu-Zhong Zhang, and Xi-Ying Zhang*, Interdomain Hydrophobic Interactions Modulate the Thermostability of Microbial Esterases from the Hormone-Sensitive Lipase Family. J. Biol. Chem.2015, 290:11188-11198.

  30. Chun-Yang Li, Tian-Di Wei, Sheng-Hui Zhang, Xiu-Lan Chen, Xiang Gao, Peng Wang, Bin-Bin Xie, Hai-Nan Su, Qi-Long Qin, Xi-Ying Zhang, Juan Yu, Hong-Hai Zhang, Bai-Cheng Zhou, Gui-Peng Yang and Yu-Zhong Zhang*, Molecular insight into bacterial cleavage of oceanic dimethylsulfoniopropionate into dimethyl sulfide, Proc Natl Acad Sci U S A.2014, 111(3):1026-1031.

  31. Sheng Dong, Tian-Di Wei, Xiu-Lan Chen, Chun-Yang Li, Peng Wang, Bin-Bin Xie, Qi-Long Qin, Xi-Ying Zhang, Xiu-Hua Pang, Bai-Cheng Zhou and Yu-Zhong Zhang*, Molecular Insight into the Role of the N-terminal Extension in the Maturation, Substrate Recognition, and Catalysis of a Bacterial Alginate Lyase from Polysaccharide Lyase Family 18, J Biol Chem. 2014, 289(43): 29558-29569

  32. Ping-Yi Li, PengJi, Chun-Yang Li, Yi Zhang, Guang-Long Wang, Xi-Ying Zhang, Bin-Bin Xie, Qi-Long Qin, Xiu-Lan Chen, Bai-Cheng Zhou and Yu-Zhong Zhang*, Structural Basis for Dimerization and Catalysis of a Novel Esterase from the GTSAG Motif Subfamily of Bacterial Hormone-Sensitive Lipase (HSL) Family, J Biol Chem. 2014, 289(27):19031-19041.

  33. Li-Yuan Ran, Hai-Nan Su, Ming-Yang Zhou, Lei Wang, Xiu-Lan Chen, Bin-Bin Xie, Xiao-Yan Song, Mei Shi, Qi-Long Qin, Xiuhua Pang, Bai-Cheng Zhou, Yu-Zhong Zhang* and Xi-Ying Zhang*, Characterization of a Novel Subtilisin-like Protease Myroicolsin from Deep Sea Bacterium Myroides profundi D25 and Molecular Insight into Its Collagenolytic Mechanism, J Biol Chem. 2014, 289(9):6041-6053.

  34. Li-Yuan Ran, Hai-Nan Su, Guo-Yan Zhao, Xiang Gao, Ming-Yang Zhou, Peng Wang, Hui-Lin Zhao, Bin-Bin Xie, Xi-Ying Zhang, Xiu-Lan Chen, Bai-Cheng Zhou and Yu-Zhong Zhang*, Structural and mechanistic insights into collagen degradation by a bacterial collagenolytic serine protease in the subtilisin family, MolecularMicrobiology. 2013, 90(5): 997-1010.

  35. Xiang Gao, Tian-Di Wei, Nan Zhang, Bin-Bin Xie, Hai-Nan Su, Xi-Ying Zhang, Xiu-Lan Chen, Yu-Zhong Zhang*, Molecular insights into the terminal energy acceptor in cyanobacterial phycobilisome, MolMicrobiol. 2012, 85(5):907-15.

  36. Hui-Lin Zhao, Xiu-Lan Chen, Bin-Bin Xie, Ming-Yang Zhou, Xiang Gao, Xi-Ying Zhang, Bai-Cheng Zhou, Anthony S. Weiss and Yu-Zhong Zhang*, Elastolytic mechanism of a novel M23 metalloprotease pseudoalterin from deep-sea Pseudoalteromonas sp. CF6-2: cleaving not only glycyl bonds in the hydrophobic regions, but also peptide bonds in the hydrophilic regions involved in crosslinking, J BiolChem. 2012,287(47):39710-20.

  37. Xiang Gao, Nan Zhang, Tian-Di Wei, Hai-Nan Su, Bin-Bin Xie, Chuang-Chuang Dong, Xi-Ying Zhang, Xiu-Lan Chen, Bai-Cheng Zhou Zhi-Xin Wang, Jia-Wei Wu, Yu-Zhong Zhang*, Crystal Structure of the N-terminal Domain of Linker LR and the Assembly of Cyanobacterial Phycobilisome Rods, 2011, Molecular Microbiology.2011, 82: 698-705.

  38. Qi-Long Qin, Yang Li, Yan-Jiao Zhang, Zhe-Min Zhou, Wei-Xin Zhang, Xiu-Lan Chen, Xi-Ying Zhang, Bai-Cheng Zhou, Lei Wang and Yu-Zhong Zhang*, Comparative genomics reveals a deep-sea sediment-adapted life style of Pseudoalteromonas sp. SM9913, The ISME Journal. 201, 5(2): 274-84.

  39. Xiang Gao, Jue Wang, Da-Qi Yu, Fei Bian, Bin-Bin Xie, Xiu-Lan Chen Bai-Cheng Zhou, Lu-Hua Lai, Zhi-Xin Wang, Jia-Wei Wu*, Yu-Zhong Zhang*, Structural Basis for the Autoprocessing of Zinc Metalloproteases in the Thermolysin Family, 2010, Proc Natl Acad Sci U S A. 2010, 107(41):17569-74.

获奖及荣誉情况

12010年,获得国家自然科学基金杰青青年基金;

22012年,获得山东省技术发明奖一等奖,第一位;

32012年,被聘为科技部863计划十二五海洋领域主题专家组专家;

42015入选国家百千万人才工程,被授予“有突出贡献的中青年专家”荣誉称号;

52017年,获得教育部自然科学奖一等奖,第一位;

62009年被入选山东省泰山学者特聘教授,2015年延聘第二期;

72018年,入选山东省“泰山学者攀登计划”专家。