叶质 ，博士，副教授
邮箱：yezhi@ouc.edu.cn
承担课程：
生物技术（本科课程）、遗传学与育种（研究生课程）
学习工作经历：
2006~2010，海南大学海洋学院，学士，水产养殖
2010~2012，中国海洋大学水产学院，硕士，水产养殖•免疫与病害
2012~2017，美国奥本大学，博士，水产养殖•分子遗传育种
2012~2017，美国奥本大学，博士，统计学（辅修）
2018~2021，美国华盛顿大学，博士后，发育生物学
2021至今，中国海洋大学海洋生命学院，副教授
2021至今，中国海洋大学三亚海洋研究院，副教授（双聘）
主要科研领域：
主要从事海洋动物遗传育种与发育生物学研究，主要研究方向包含：1）利用高通量组学技术，结合转基因和基因编辑技术揭示水产动物经济性状决定的遗传分子机理；2）挖掘关键基因和基因型并据此进行海洋动物定向精准分子设计育种；3）水产动物分子辅助育种和基因组选育；4）海洋动物胚胎发育的表观遗传学研究。已在国内外主流刊物发表SCI论文40余篇，成果发表在Development、Zoological Research、Aquaculture等国际权威期刊上；授权国家发明专利6项。近五年主持承担各类科研项目10余项，包括国家自然科学基金青年基金、国家重点研发计划子课题、海南省“南海新星”科技创新专项、海南省科技计划三亚崖州湾科技城自然科学基金联合项目等省级及以上科研项目8项；入选山东省泰山学者青年专家。
代表性成果：（#共同第一；*通讯作者）
1. Z. Ye, C. R. Braden, A. Wills, D. Kimelman, Identification of in vivo Hox13-binding sites reveals an essential locus controlling zebrafish brachyury expression. Development 148, dev199408 (2021). (Interviewed by Science in Seattle)
2. Z. Ye, D. Kimelman, Hox13 genes are required for mesoderm formation and axis elongation during early zebrafish development. Development 147 (2020). (Highlighted and interviewed by Development)
3. J. Shi, J. Liu, Z. Wei, M. Yin, Z. Yang, J. Hu, Z. Ye*, Z. Bao, Epigenetic Regulation and Maternal-to-Zygotic Transition in Dwarf Surf Clam (Mulinia lateralis): Insights from Chromatin State Profiling and Transcriptomics. Zoological Research (2025).
4. J. Shi, Z. Qi, M. Yin, Q. Zeng, J. Hu, Z. Bao, Z. Ye*, Dynamic epigenomic landscape and gene regulatory networks during embryonic development in Pacific white shrimp (Litopenaeus vannamei) as revealed by histone modification profiling using CUT&Tag. Epigenetics & Chromatin 18, 50 (2025).
5. G. Zhou, Z. Ye#, J. Luo, D. Zhang, W. Thongda, Y. Xu, M. Chen, S. Wang, A. Elaswad, W. Guo, Intestinal microbiota and gene expression alterations in leopard coral grouper (Plectropomus leopardus) under enteritis. Fish & Shellfish Immunology 150, 109644 (2024).
6. Z. Ye*, A. Elaswad, G. Qin, D. Zhang, B. Su, K. Khalil, Z. Qin, N. Y. Abass, Q. Cheng, R. Odin, K. Vo, N. Backenstose, D. Drescher, M. Shang, H. Li, D. Zhang, W. S. Bugg, K. Gosh, R. A. Dunham, Sterilization of Channel Catfish (Ictalurus punctatus) via Overexpression of bax Gene Regulated by a Tet-off System in the Primordial Germ Cells. Mar Biotechnol 27, 79 (2025).
7. A. Elaswad, K. Khalil, Z. Ye*, Z. Liu, S. Liu, E. Peatman, R. Odin, K. Vo, D. Drescher, K. Gosh, G. Qin, W. Bugg, N. Backenstose, R. Dunham, Effects of CRISPR/Cas9 dosage on TICAM1 and RBL gene mutation rate, embryonic development, hatchability and fry survival in channel catfish. Sci Rep 8, 16499 (2018).
8. Z. Qi, J. Liu, J. Shi, M. Yin, J. Liu, J. Fan, Z. Bao, Z. Ye*, J. Hu*, Integrated Transcriptomic and Epigenomic Analysis Reveals Mechanisms Underlying Melanotic Spot Formation in Red Tilapia (Oreochromis spp.). International Journal of Molecular Sciences 26, 4370 (2025).
9. Z. Ye*, A. Elaswad, B. Su, A. Alsaqufi, M. Shang, W. S. Bugg, G. Qin, D. Drescher, H. Li, Z. Qin, R. Odin, N. Makhubu, N. Abass, S. Dong, R. Dunham, Reversible Sterilization of Channel Catfish via Overexpression of Glutamic Acid Decarboxylase Gene. Animals (Basel) 14, 1899 (2024).
10. D. Zhang, E. Peatman, B. H. Beck, H. Zhao, J. Mazzola, B. Su, A. Elaswad*, Z. Ye*, Liver and intestine transcriptome analysis reveals molecular mechanisms of phytase-driven nutrient utilization and metabolic regulation in hybrid catfish. Comparative Biochemistry and Physiology Part D: Genomics and Proteomics 56, 101539 (2025).
