连姗姗

连姗姗  博士“英才三”副教授/硕士生导师

地址：山东省青岛市中国海洋大学海洋生命学院

邮箱E-mail: lianshanshan@ouc.edu.cn

教育经历Academic qualifications:

2008-2013，中国海洋大学海洋生命学院，海洋生物学，博士

2004-2008, 中国海洋大学海洋生命学院，生物科学，学士

工作简历Working Experience:

2020-至今中国海洋大学，海洋生命学院，副教授

2017-2020 中国海洋大学海洋生命学院，遗传学，博士后研究员

2013-2017 美国斯普里克斯研究所（Scripps，FL，USA），Metabolism & Aging，博士后研究员

研究领域Research interests:

主要从事功能基因组学研究，近年来主要在针对动物发育、进化等生物学过程的分子调控机制解析及重要性状相关基因的功能研究方面取得了重要的成果，发表在包括Science Advances、The Innovation、Nucleic Acids Research、Nature Ecology & Evolution、Autophagy、PNAS等在内的国际知名期刊上。

主持项目Research projects：

1. 中国海洋大学“青年英才工程”科研启动经费，30万

2. 国家自然科学基金青年基金：32002373，24万

3. 国家实验室“渔业青年科技人才”：2018-MFS-T06，25万

4. 国家重点研发计划青年科学家项目课题主持：2022YFD2401400，60万

论文发表Publication records: (^#共首作者co-first author, *通讯作者)

Lian S (#), Hu N (#), Chen X(#), et al. (2025). Widespread presence of bone marrow-like hematopoietic stem cell niche in invertebrate skeletons, Science Advances, 11(26): eadw0958. IF: 14.1

Lian S (#), Lv J (#), Li Y, et al. (2025). Marine evo-devo: New frontiers from Lophotrochozoa, The Innovation, 6(6): 100869. IF: 40.2

Liu F (#), Cai B(#), Lian S(#) et al. (2025). MolluscDB 2.0: a comprehensive functional and evolutionary genomics database for over 1400 molluscan species. Nucleic Acids Research, 53(D1), D1075-D1086. IF: 16.8

Wang J(#), Zhang L(#), Lian S(#), Qin Z(#), Zhu X(#), Dai X, Huang Z, Ke C, Zhou Z, Wei J, Liu P, Hu N, Zeng Q, Cui C, Dong B, Dong Y, Kong D, Zhang Z, Liu S, Xia Y, Li Y, Zhao L, Xing Q, Huang X, Hu X, Bao Z, Wang S(*) (2020). Evolutionary transcriptomics of metazoan biphasic life cycle supports a single intercalation origin of metazoan larvae. Nature Ecology & Evolution: 1-12. IF: 17.6

Sasaki T(#), Lian S(#), Khan A, Llop J, Samuelson A, Chen W, Klionsky D and Kishi S(*) (2017). Autolysosome biogenesis and developmental senescence are regulated by both Spns1 and v-ATPase. Autophagy 13(2): 386-403.IF: 17.1

Song Y(#), Shi Y(#), Carland T, Lian S, Sasaki T, Schork N , Head S, Kishi S(*) and Schimmel P(*) (2016). p53-Dependent DNA damage response sensitive to editing-defective tRNA synthetase in zebrafish. Proceedings of the National Academy of Sciences of the United States of America 113(30): 8460-8465. IF: 11.2

Sasaki T, Lian S, Qi J, Bayliss P, Carr C, Johnson J, Guha S, Kobler P, Catz S, Gill M, Jia K, Klionsky D and Kishi S(*) (2014). Aberrant Aautolysosomal regulation is linked to the induction of embryonic senescence: differential roles of Beclin 1 and p53 in vertebrate Spns1 deficiency. Plos Genetics 10(6). IF: 5.9

Wang Y(#), Zhu X(#), Lian S(*), Li Y, Hu N, Hu X, Bao Z and Wang S (2022). Functional characterization of Cfap206 for bivalve ciliogenesis by RNAi and CRISPR/Cas9 technologies. Frontiers in Marine Science. IF: 4.9

Hu N, Lian S(*), Zhu X, Chen X, Sun F, Zhang L, Wang S, Bao Z and Hu J(*). (2022). Interferon regulatory factors functioned as activators of the interferon pathway in the scallop Chlamys farreri. Frontiers in Marine Science, 575. IF: 4.9

Chen X(#), Hu N(#), Lian S(*), Li L, Sun F, Zhang L, Wang S, Bao Z and Hu J(*). (2022). Genome-wide identification and expression profiling of the COMMD gene family in four bivalve molluscs. Frontiers in Marine Science, 9: 884991. IF: 4.9

Xu K(#), Wang Y(#), Lian S(*),Hu N, Chen X, Dai X, Zhang L, Wang X, JHu J, Hu X, Bao Z (2021). Expansion of C1Q genes in Zhikong scallop and their expression profiling after exposure to the toxic dinoflagellates. Frontiers in Marine Science. IF: 4.9

Zhu X(#), Zhang F(#), Lian S(*), Wang Y, Hu N, Chen X, Dai X, Hu X, Wang S, Bao Z (2021). IAPs gene expansion in the scallop Patinopecten yessoensis and their expression profiles after exposure to the toxic Dinoflagellate. Frontiers in Physiology. IF: 4.6

Zhao L(#), Lian S(#), en Q, Yang Z, Guo Z, Lou J, Kong X, Li M, Bao Z, Hu X(*)(2021). In vivo and rapid assessment of scallop muscle trait. Aquaculture. IF: 4.2

Lian S(#), Zhao L(#), Xun X, Lou J, Li M, Li X, Wang S, Zhang L, Hu X(*) and Bao Z (2019). Genome-wide identification and characterization of SODs in Zhikong scallop reveals gene expansion and regulation divergence after toxic dinoflagellate exposure. Marine Drugs 17(12): 700. IF: 5.1

Lian S(#), Wang J(#), Zhang L, Xing Q, Hu N, Liu S, Dai X, Zhang F, Hu X, Bao Z and Wang S(*) (2019). Integration of biochemical, cellular, and genetic indicators for understanding the aging process in a bivalve mollusk Chlamys farreri. Marine Biotechnology 21: 718-730. IF: 3.6

Zhao L(#), Li Y(#), Lou J, Yang Z, Liao H, Fu Q, Guo Z, Lian S(*), Hu X and Bao Z (2019). Transcriptomic profiling provides insights into inbreeding depression in Yesso scallop Patinopecten yessoensis. Marine Biotechnology 21: 623-633.IF: 3.6

Li X(#), Wang S(#), Xun X, Zhang M, Wang S, Li H, Zhao L, Fu Q, Wang H, Li T, Lian S, Xing Q, Li X, Wu W, Zhang L, Hu X(*) and Bao Z (2019). A carotenoid oxygenase is responsible for muscle coloration in scallop. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1864(7): 966-975. IF: 4.7

Li Y, Wang R, Xun X, Wang J, Bao L, Thimmappa R, Ding J, Jiang J, Zhang L, Li T, Lv J, Mu C, Hu X, Zhang L, Liu J, Li Y, Yao L, Jiao W, Wang Y, Lian S, Zhao Z, Zhan Y, Huang X, Liao H, Wang J, Sun H, Mi X, Xia Y, Xing Q, Lu W, Osbourn A, Zhou Z(*), Chang Y(*), Bao Z(*), and Wang S(*) (2018). Sea cucumber genome provides insights into saponin biosynthesis and aestivation regulation. Cell Discovery, 4:29. IF: 10.9

Liu S(#), Chen X(#), Lian S(*), Dai X, Hu N, Zhang F, Zhang L, Bao Z and Wang S (2018). Genome-wide identification and expression profiling of the Wnt gene family in three bivalve molluscs. Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics. 29: 299-307.

授权专利：

 (1) 连姗姗; 包振民; 王师; 胡晓丽; 赵亮; 杨祖晶; 朱晓梅; 汪星磊; 一种适用于贝类软体动物卵的外源物质导入方法, 2022-06-07, 中国, ZL 2019 1 0745401.2 (专利)

(2) 连姗姗; 胡乃娜; 王师; 王静; 吕佳; 张玲玲; 一种贝类幼虫期快速、高效的壳分离方法, 2025-03-11, 中国, ZL 2024 1 1497409.9 (专利)

(3) 王师; 牛艺霖; 连姗姗; 陈晓妹; 李玉凤; 戴晓婷; 张玲玲; 包振民; 一种跨动物门类适用的矿化外壳来源的单细胞悬液制备方法, 2025-10-14, 中国, ZL 2025 1 0873572.9 (专利)

(4) 王师; 巩文燕; 连姗姗; 庄汝浩; 张玲玲; 王静; 包振民; 一种用于虾夷扇贝血淋巴细胞体外培养的无血清培养基, 2024-10-18, 中国, ZL 2024 1 1024828.0 (专利)

(5) 胡晓丽; 孔令玲; 连姗姗; 王慧贞; 张翔超; 孔祥福; 包振民; 一种双壳贝类生长调控基因的功能验证方法, 2023-08-15, 中国, ZL 2022 1 1669631.3 (专利)

(6) 胡晓丽; 孔令玲; 王晨; 连姗姗; 王慧贞; 张翔超; 孔祥福; 包振民; 一种提高侏儒蛤生长速度的方法, 2023-12-10, 中国, ZL 2022 1 1671071.5 (专利)

(7) 胡晓丽; 孔祥福; 赵亮; 黄山桓; 连姗姗; 梁浩颖; 包振民; 一种快速无损地检测贝类体尺和闭壳肌性状的装置, 2024-12-27, 中国, ZL 2023 2 2532154.2 (专利)