1、基本情况
刘晨光 理学博士 中国海洋大学 海洋生命学院教授
学习简历
1986,9-1990,7曲阜师范大学生物学系 获学士学位
2002,12~2005,8高丽大学(韩国)生命科学与技术学院 获博士学位
工作简历
1990,9-1992,7济南槐荫中学
1995,9~1996,12中国海洋大学 助教
1997,1~2002,12中国海洋大学 讲师
2003,1~2007,12中国海洋大学 副教授
2008,1~至今 中国海洋大学 教授（2008年7月获博士生导师资格）
2013,6~2022,1海洋生命学院 副院长
2010,4~至今 国家海洋生命科学与技术人才培养基地 副主任
2022,8~至今 青岛市海洋生物基医学美容材料技术创新中心 主任
主要学术兼职：青岛生理科学会常务理事；青岛药膳研究会副理事长
任现职以来主要教学业绩
从事生物化学的和海洋生物技术教学工作。获2022年山东省教学成果一等奖、2021年中国海洋大学第十三届优秀教学成果一等奖、2021年中国海洋大学第二届研究生教育成果二等奖。
科研领域及学术贡献
从事生物化学的教学和海洋生物技术与医用生物材料的研究工作。曾主持国家“863”项目2项、教育部留学回国留学基金1项、山东省中青年奖励基金1项、山东省自然科学基金3项；获2008教育部新世纪优秀人才支持计划。2017年作为首席科学家与青岛优度生物技术有限公司共建青岛市海洋生物活性物质专家工作站；入选2020年度烟台市“双百计划”人才（兼职创新类）。
主要科研领域：
1、微/纳米生物材料：是指用于对生物体进行诊断、治疗、修复或替换其病损组织、器官或增进其功能的具有微纳米结构或微纳米尺度的新型生物材料，已成功地制备了壳聚糖、海藻酸、透明质酸、海蜇胶原、浒苔多糖等多种微/纳米复合材料；建立了基于适配体和碳量子点的病原微生物传感器。研究成果获高等学校科学研究优秀成果奖（科学技术）、山东省高等学校优秀科研成果自然科学奖二等奖、青岛市科学技术发明二等奖。
2、海洋生物技术：是指运用海洋生物学与工程学的原理和方法，利用海洋生物或生物代谢过程生产有用的生物制品。该研究方向主要进行海洋生物材料（如多糖、蛋白质（酶）、脂质）的分离、纯化、改性、鉴定及相关应用基础研究，已成功地分离纯化了多种新型的海洋多糖、海洋生物酶等。 研究成果获教育部提名国家科技进步二等奖、海洋科学技术奖二等奖。
以上成果发表相关学术论文100（其中SCI论文50余篇）余篇，获专利证书10项，在医药、食品和化妆品等领域显示出良好的应用前景，如与青岛优度生物技术有限公司合作研发的虾青素纳米乳精华于2019年被认定为青岛市中小企业专精特新产品（技术），在市场推广中得到消费者广泛认可，2019-2022年间数十款新产品基于该技术完成了开发和产业化生产，实现销售收入3350万元。
5）发表论文列表
2024
1.Kamankesh M, Yadegar A, Llopis-Lorente A, Liu C, Haririan I, Aghdaei HA, Shokrgozar MA, Zali MR, Miri AH, Rad-Malekshahi M, Hamblin MR, Wacker MG. Future Nanotechnology-Based Strategies for Improved Management of Helicobacter pylori Infection Small [J]. 2024 20，e2302532.2022
2.Cui Z., Jiang F., Li L. Chi Z., Liu C. Advances in Biomedical Applications of Hydrogels from Seaweed-Derived Sulfated Polysaccharides: Carrageenan, Fucoidan, and Ulvan. Journal Ocean University China [J] 2024,23, 1329–1346
3. Jiang F., Li L., Tian Y., Su Y., Zhao T., Ren R., Chi Z., Liu C. Enteromorpha Prolifera Polysaccharide-Derived Injectable Hydrogel for Fast Intraoperative Hemostasis and Accelerated Postsurgical Wound Healing Following Tumor Resection. Advanced Healthcare Materials [J] 2024;13(10):e2303456.
4. Jiang F, Su Y., Zhao T., Ren R., Chi Z., Liu C., An injectable hydrogel of Enteromorpha polysaccharide/gelatin–derivatives inspired by siderophores and biocatalysis for addressing all phases of chronic diabetic wound healing. Chemical Engineering Journal [J], 2024, 490, 151787,
5. Sharaf M., Zahra A. A, Alharbi M., Mekky A. E, Shehata A. M, Alkhudhayri A., AliA. M, Suhaimi E. A Al, Zakai 11 S.A, Harthi N. A., Liu C. Bee chitosan nanoparticles loaded with apitoxin as a novel approach to eradication of common human bacterial, fungal pathogens and treating cancer. Frontier Microbiology [J] . 2024,15,1345478.
6. Yu L., Tian Y.， Ding Y., Chi Z., Liu C., Chitosan/β-glycerophosphate porous microsphere prepared by facile water-in-water emulsion as a topical hemostatic material. International Journal of Biological Macromolecules [J], 277, 2024, 133683,
7. Tian Y., Jiang F., Xie H., Chi Z., Liu C., Conductive Hyaluronic Acid/Deep Eutectic Solvent Composite Hydrogel as a Wound Dressing for Promoting Skin Burn Healing Under Electrical Stimulation.Advanced Healthcare Materials[J]. 2024;13(17): e2304117.
8. Qu Q., Cui Z., Jiang F., Liu C. Strength and targeted-sustained release properties of sodium alginate-polyacrylamide hydrogel for anti-wrinkle eye-patch. Journal of Drug Delivery Science and Technology [J].2024 100 106065
9. Li, Q., Liu, C. & Xing, D. Carbon dots-facilitated on-demand dissolution of Ca-alginate hydrogel via site-specific mineralization for wound healing. Journal Nanobiotechnology [J].2024 22, 465
2023
1. Cheng X., Geng J., Wang L., Ma X., Su Y., Arif M., Liu C. Berberine-loaded mannosylerythritol lipid-B nanomicelles as drug delivery carriers for the treatment of Helicobacter pylori biofilms in vivo. European Journal of Pharmaceutics and Biopharmaceutics [J].2023 193 105–118
2. Li Q., Shen X., Liu C., Xing D. Facile wound dressing replacement: Carbon dots for dissolving alginate hydrogels via competitive complexation International Journal of Biological Macromolecules [J].2023 240 124455
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3 Hamouda.H. I., Mohamed S. Selim, Higazy S. A., Shabana S., Hao Z., Liu C. Novel nanoblades of graphene oxide decorated with zinc oxide nanocomposite as a powerful anti-microbial active weapon. Synthetic Metals [J].2023 296 117349
4. Tian Y., Zhu M., Hu T., Liu C. Natural deep eutectic solvent—A novel green solvent for protein stabilization. International Journal of Biological Macromolecules [J].2023 247 125477
2022
1. Miri A. H., Mojtaba K., Antoni L.-L., Liu C., Wacker,M. G., Haririan I. , Aghdaei H. A., M.. Hamblin R., Yadegar A., Rad-Malekshahi M. and Zali M. R. The Potential Use of Antibiotics Against Helicobacter pylori Infection: Biopharmaceutical Implications Frontiers in Pharmacology[J]. 2022 doi: 10.3389/fphar.2022.917184
2.Arif M., Ahmad R., Sharaf M., Mohnad Abdalla M., Muhammad J., Eltayb W.A., and Liu, C.G.. Antibacterial and antibiofilm activity of mannose modified Chitisan/PMLA nanoparticales aginst multidrug-resistant Helicobacter pylori. International Journal of Biological Macromolecules[J]., 2022 223 418-432
3.Shabana.S, Hamouda , H Abdalla, M.; Sharaf M., Chi Z. and Liu C. Multifunctional nanoparticles based on marine polysaccharides for apremilast delivery to inflammatory macrophages: Preparation, targeting ability, and uptake mechanism, International Journal of Biological Macromolecules[J].,2022 222 1709-1722.
4. Wu Y., Geng J, Cheng X., Yang Y., Yu Y., Wang L., Dong Q., Chi Z., and Liu C. Cosmetic-Derived Mannosylerythritol Lipid-B-Phospholipid Nanoliposome: An Acid-Stabilized Carrier for Efficient Gastromucosal Delivery of Amoxicillin for In Vivo Treatment of Helicobacter pylori ACS Omega[J]. 2022, 7, 29086−29099
5. Jiang F., Ding Y., TianY., Yang R., Quan M., Tong Zh., Zhang X., Luo D., Chi Z., Liu C. Hydrolyzed low-molecular-weight polysaccharide from Enteromorpha prolifera exhibits high anti-inflammatory activity and promotes wound healing. Biomaterials Advances[J]. 2022 133 112637
6.Kazharskaia M. · Muhammad A. · Ding Y. ·Chi Z. · Liu C. Preparation of Novel Hard Capsule Using Water Soluble Polysaccharides and Cellulose Nanocrystals for Drug Delivery. Journal of Pharmaceutical Innovation [J].2022 18, 675–686
7.Mohamed S., Muhammad A., Hamed I. H., Sohaib K., Mohnad A. Samah S., Hussein. E. R., Tehsin U. K., Chi Z., Liu C. Preparation, urease inhibition mechanisms, and anti-Helicobacter pylori activities of hesperetin-7-rhamnoglucoside Current Research in Microbial Sciences [J].2022 3 100103
8. Cheng, XH; Liu, WX; Wang, ZZ; Yang, RX; Yu, LJ; Du, QB; Ge, AS; Liu, CG; Chi, Z Improved triple-module fluorescent biosensor for the rapid and ultrasensitive detection of Campylobacter jejuni in livestock and dairy Food Control [J].2022 137 108905
9. Geng, JY; Wang, ZZ; Wu, YP; Yu, LJ;Wang, LL; Dong, GJ; Liu, CG; Chi, Z Intrinsic specificity of plain ammonium citrate carbon dots for Helicobacter pylori: Interfacial mechanism, diagnostic translation and general revelation. Materials Today Bio[J]. 2022 15 100282
2021
1.Muhammad A., Mohamed S., Samreen, Sohaib K., Chi Z. and Liu C. Chitosan-based nanoparticles as delivery- carrier for promising antimicrobial glycolipid biosurfactant to improve the eradication rate of Helicobacter pylori biofilm, Journal of Biomaterials Science, Polymer Edition[J]. 2021 32 813-832
2. Sun Q., Muhammad A. Chi Z., Li G., Liu C. Macrophages-targeting mannosylated nanoparticles based on inulin for the treatment of inflammatory bowel disease (IBD). International Journal of Biological Macromolecules[J]. 2021 169 206–215
3.Jiang F.; Chi, Z.; Ding, Y.; Quan M.; Tian Y.; Shi J.; Song F.; Liu, C. Wound Dressing Hydrogel of Enteromorpha prolifera Polysaccharide–Polyacrylamide Composite: A Facile Transformation of Marine Blooming into Biomedical Material ACS Applied Materials & Interfaces[J]. 2021 13 14543-14555
4. Mohamed S.; Samah S.; Sohaib K.; Muhammad A.; Hussein E.R.; Chi Z.; Liu C. Design of lipid-based nanocarrier for drug delivery has a double therapy for six common pathogens eradicationColloids and Surfaces A: Physicochemical and Engineering Aspects[J]. 2021625:126662
5. Mohamed S.,; Muhammad A.; Sohaib K.,; Samah S.,; Chi, Z.; Liu, C. Co-delivery of hesperidin and clarithromycin in a nanostructured lipid carrier for the eradication of Helicobacter pylori in vitro. Bioorganic Chemistry [J].2021 112 WOS:000661873800004
6. Sun, Q. Xu, Zhao X. H. Liu, C. Novel application of agarose in cultivating microorganisms in the stomach and rapid drug susceptibility testing of Helicobacter pylori. Materials Express[J]. 2021 11 880-887
7.Xing F.; Chi Z.; Yang R.; Xu D.; Cui J.; Huang Y.; Zhou C.; Liu C. Chitin-hydroxyapatite-collagen composite scaffolds for bone regeneration International Journal of Biological Macromolecules[J]. 2021 184, 170-180
8. Kazharskaia M.; Muhammad A.; Shi J.; Song F.; Chi Z.; Liu C. Novel chitosan-ulvan hydrogel reinforcement by cellulose nanocrystals with epidermal growth factor for enhanced wound healing: In vitro and in vivo analysis International Journal of Biological Macromolecules[J]. 2021 183 435-446
9. Sohaib K. , Mohamed S. , , Ishfaq A. , Tehsin U.K. , Samah S. , Muhammad A. , Syed S. U. Hassan K. , and Liu C. Potential utility of nano-based treatment approaches to address the risk of Helicobacter pylori Expert Review of Anti-infective Therapy. Expert Review of Anti-Infective Therapy[J].. 2022 ;20(3):407-424
10.Arif ,M. Sharaf M., Samreen, Dong Q., Wang L., Chi Z., Liu C., Bacteria-Targeting Chitosan/Carbon Dots Nanocomposite with Membrane Disruptive Properties Improve Eradication Rate of Helicobacter pylori Journal of Biomaterials Science, Polymer Edition [J].2021 . 32 2423-2447
11. Jiang F., Ding Y., Tian Y., Yang R., Quan M., Tong Z., Zhang X., Luo D., Chi Z., Liu C. Hydrolyzed low-molecular-weight polysaccharide from Enteromorpha prolifera exhibits high anti-inflammatory activity and promotes wound healing. Materials Science & Engineering C[J]. 2022 133, 112637
12. Mohamed S., Muhammad A., Hamed I. H., Sohaib K., Mohnad A., Samah S., H. E. Rozan, Tehsin Ul. K., Chi Z., Liu C., Preparation, urease inhibition mechanisms, and anti-Helicobacter pylori activities of hesperetin-7-rhamnoglucoside. Current Research in Microbial Sciences[J]. 3 2022, 100103
2020
1.Zhang P., Guo H. and Liu C. Fabrication of Carboxylmethyl Chitosan Nanocarrier via Self-Assembly for Efficient Delivery of Phenylethyl Resorcinol in B16 Cells. Polymers[J] 2020, 12, 408; doi:10.3390/polym12020408
2. Ding Y., Jiang F., Chen L., Lyu W. , Chi Z., Liu C., Chi Z. An Alternative Hard Capsule Prepared with the High Molecular Weight Pullulan and Gellan: Processing, Characterization, and In Vitro Drug Release. Carbohydrate Polymers [J] 2020 237 116172
3. Wang L. , Xin Y., Zhou J., Tian Z., Liu C., Yu X., Meng X., Jiang W., Zhao S., Dong Q. Gastric mucosa-associated microbial signatures of early gastric cancer Frontiers in Microbiology[J] 2020 11 10.3389/fmicb.2020.01548
4. Wang H.; Wang, Z.; Liu, G.; Cheng, X.; Chi, Z.; Madzak, C.; Liu, C.; Chi, Z. Genetical Surface Display of Silicatein on Yarrowia lipolytic Confers Living and Renewable Biosilica-Yeast Hybrid Materials. ACS Omega[J] 2020https://dx.doi.org/10.1021/acsomega.0c00393
5. Zhang P., Liu C. Enhancement of Skin Wound Healing by rhEGF-Loaded Carboxymethyl Chitosan Nanoparticles Polymers [J]2020, 12, 1612; doi:10.3390/polym12071612
6. Arif M., Chi Z., Liu Y., Liu C. Preparation, characterization, and in vitro drug release behaviour of thiolated-alginate nanoparticles loaded budesonide as a potential drug delivery system towards inflammatory bowel diseases Journal of Biomaterials Science, Polymer Edition[J]2020,31 18 2299-2317
7. Zhang P., Zhang Y. and Liu C. Polymeric nanoparticles based on carboxymethyl chitosan in combination with painless microneedle therapy systems for enhancing transdermal insulin delivery RSC Advances[J], 2020, 10, 24319–24329
2019
1.Kazharska M, Ding Y, Arif M, Jiang F, Cong Y, Wang H, Zhao C, Liu X, Chi Z, Liu C. Cellulose nanocrystals derived from Enteromorpha prolifera and their use in developing bionanocomposite films with water-soluble polysaccharides extracted from E. prolifera. International Journal of Biological Macromolecules [J] 2019 134:390-396
2.Luan L., Chi, Z.; Liu, C. Chinese White Wax Solid Lipid Nanoparticles as a Novel Nanocarrier of Curcumin for Inhibiting the Formation of Staphylococcus aureus Biofilms Nanomaterials (Basel) [J]. 2019; 9(5): 763.
3. Zhang P., Zhao S., Yu Y. , Wang H., Yang Y., Liu C. Biocompatibility Profile and In Vitro Cellular Uptake of Self-assembled Alginate Nanoparticles. Molecules [J]2019, 24, 555
4. Li Q., Xue F., Qu J. Liu L., Hu R., Liu C. Nano-in-Micro Delivery System Prepared by Co-Axial Air Flow for Oral Delivery of Conjugated Linoleic Acid Marine Drugs [J]2019, 17, 15; doi:10.3390/md 17010015
5. Cong Y., Geng J., Wang H., Su J., Arif M, Dong Q. Chi, Z.; Liu, C. Liu Ureido-modified carboxymethyl chitosan-graft-stearic acid polymeric nano-micelles as a targeted delivering carrier of clarithromycin for Helicobacter pylori: Preparation and in vitro evaluation International Journal of Biological Macromolecules [J]2019 129:686-692
6.LI Jiaxin, ZHANG Pei, HONG Liang, and LIU Chenguang Purification and Characterization of a Novel Hydrolase That Can Specifically Degrade the Polysaccharide Isolated from Green Seaweed Ulva prolifera. Journal of Ocean University of China (Oceanic and Coastal Sea Research) [J]2019 18 (1): 185-192
2018
1. Arif, M.; Raja, M. Ali; Zeenat, S.; Chi, Z.; Liu, C. Development of novel pH-sensitive thiolated chitosan/PMLA nanoparticles for amoxicillin delivery to treat Helicobacter pylori. Materials Science & Engineering C [J] 2018 83: 17–24
2. Sun Q.; Luan L.; Arif M. Li J,; Chi Z.; Liu C. Redox-sensitive nanoparticles based on 4-aminothiophenol-carboxymethyl inulin conjugate for budesonide delivery in inflammatory bowel diseases. Carbohydrate Polymers [J] 218 189 352–359
3.Li J, Jiang, F., Chi, Z, Han D, Yu L, Liu C. Development of Enteromorpha prolifera polysaccharide-based nanoparticles for delivery of curcumin to cancer cells International Journal of Biological Macromolecules [J] 2018 112:413-421
4. Li CB, Liu CG Characterization of Agarose Microparticles Prepared by Water-in-water Emulsification. Particulate Science and Technology [J]2018 36: 592-599
2017
1. Li Q., Hong L., Li HG *, Liu CG *. Graphene oxide-fullerene C60 (GO-C60) hybrid for photodynamic and photothermal therapy triggered by near-infrared light. Biosensors and Bioelectronics [J], 2017: 89 477–482
2. Raja MA, Arif M, Feng C, Zeenat S, Liu CG. Synthesis and evaluation of pH-sensitive, self-assembled chitosan-based nanoparticles as efficient doxorubicin carriers. Journal of Biomaterials Applications [J]. 2017 31：1182-1195.
3.Arif M, Raja MA, Zeenat S, Chi Z, Liu CG. Preparation and characterization of polyelectrolyte complex nanoparticles based on poly (malic acid), chitosan. A pH-dependent delivery system. Journal of Biomaterials Science, Polymer Edition. [J] 2017: 28 50-62..
4. Cheng X, Shao Z, Li C, Yu L, Raja MA, Liu CG. Isolation, Characterization and Evaluation of Collagen from Jellyfish Rhopilema esculentum Kishinouye for Use in Hemostatic Applications. PloS one. 2017 Jan 19; 12(1):e0169731.
5. Hong L., Chen F, Han D, Wang, C., Li, J., Chi, Z., Liu, C. Development of a carboxymethyl chitosan functionalized nanoemulsion formulation for increasing aqueous solubility, stability and skin permeability of astaxanthin using low-energy method. Journal of Microencapsulation [J]2017 34: 707-721
6. Hong L., Han D., Li MX, Zhang P., Liu CG Development and validation of an Ultraviolet–visible (UV-Vis) spectrophotometric method for determination of phenylethyl resorcinol in new topical nanoemulsions, International Journal of Cosmetic Science, [J]2017: 39 337–343
7. Li JX, Chi Z., Yu LJ, Jiang F, Liu CG Sulfated modification, characterization, and antioxidant and moistureabsorption/retention activities of a soluble neutral polysaccharidefrom Enteromorpha prolifera International Journal of Biological Macromolecules [J]2017 105:1544-1553
2016
1. Raja MA Zeenat S Arif M. Liu CG * Self-assembled nanoparticles based on amphiphilic chitosan derivative and arginine for oral curcumin delivery International Journal of Nanomedicine [J] 2016:11 4397–4412
2. Wang S, Zheng L, Cui ZS, Chen JH, Yang BJ, Han XT, Liu CG Cloning and molecular characterization of a delta-6 fatty acid desaturase gene from Isochrysis sp. CCMM5001 Journal of Applied Phycology [J]2016 28:921–929
2015
1. Zhang P, Zhao SR, Li JX, Hong L, Raja MA, Yu LJ, Liu CG Nanoparticles based on phenylalanine ethyl ester-alginate conjugate as vitamin B-2 delivery system Journal of Biomaterials Applications [J] 2016, 31: 13-227.
2. Tan Y., Ma S., Liu C., Yu W., Han F. Enhancing the stability and antibiofilm activity of DspB byimmobilization on carboxymethyl chitosan nanoparticles. Microbiological Research [J]2015 178: 35–41
3.Li, Q., Liu, C ., Yu, Y.，Separation of monodisperse alginate nanoparticles and effect of particle size on transport of vitamin E. Carbohydrate Polymers [J]2015 124: 274-279
4. Wei W., Dong X. and Liu C. In Vitro Investigation of Self-Assembled Nanoparticles Based on Hyaluronic Acid-Deoxycholic Acid Conjugates for Controlled Release Doxorubicin: Effect of Degree of Substitution of Deoxycholic Acid. International Journal of Molecular Sciences [J], 2015, 16: 7195-7209
5. Raja M. A., Liu C. Huang Z. Nanoparticles based on Oleate Alginate Ester as Curcumin Delivery System. Current Drug Delivery [J], 2015, 12: 613-627
2013
1. Li, Q.; Yu Y.; Liu C. Preparation and evaluation of nanoparticles with narrow size distribution for oral delivery. Journal of Controlled Release [J] 2013 172(1):e21-2
2012
1.Wu JL, Liu CG, Wang XL, Huang ZH. Preparation and characterization of nanoparticles based on histidine-hyaluronic acid conjugates as doxorubicin carriers. Journal of Materials Science: Materials in Medicine [J] 2012, 23:1921-1929.
2.Ji S.; Zhao R.; Qi Yin; Liu C.; Zhang X. Gel microbead cultivation with a subenrichment procedure can yield better bacterial cultivability from a seawater sample than standard plating method. Journal of Ocean University of China [J] 2012 11 45-51
2011
1. Li Q., Liu C., Huang Z, and Xue F. Preparation and Characterization of Nanoparticles Based on Hydrophobic Alginate Derivative as Carriers for Sustained Release of Vitamin D3 Journal of Agricultural and Food Chemistry. [J];2011, 59, 1962–1967
2010
1. Dong X., Liu C. Preparation and Characterization of Self-Assembled Nanoparticles of Hyaluronic Acid-Deoxycholic Acid Conjugates. Journal of Nanomaterials [J] 2010, doi:10.1155/2010/906936
2009
1. Tan Y., Liu C. Self-aggregated nanoparticles from linoleic acid modified carboxymethyl chitosan: Synthesis, characterization and application in vitro Colloids and Surfaces B: Biointerfaces [J] 2009 69 178–182
2008
1.Yu-long Tan, Liu C. Chen X. Effect of linoleic-acid modified carboxymethyl chitosan on bromelain immobilization onto self-assembled nanoparticles 2008 Frontiers of Materials Science in China [J] 2008 2(2) 209-213
2006
1.Chen, X.；Liu C. S.; Liu C. Preparation and biocompatibility of chitosan microcarriers as biomaterial. Biochemical Engineering Journal [J] 2006 27 269-274
2005
1. Desai K.G.H, Liu C. and Park H.J. Characteristics of vitamin C immobilized particles and sodium alginate beads containing immobilized particles. Journal of Microencapsulation [J] 2005; 22(4); 363-376
2. Liu, C.-G.; Desai, K. G. H.; Chen, X.-G.; Park, H.-J. Preparation and characterization of nanoparticles containing trypsin based on hydrophobically chitosan. Journal of Agricultural and Food Chemistry [J]; 2005, 53, 1728-1733
3. Liu C., Chen X., Park H. Self-assembled nanoparticles based on linoleic-acid modified chitosan: Stability and adsorption of trypsin. Carbohydrate Polymers [J] 2005 62 293–298
