陈西广

姓名：陈西广

学历/职称/职务： 博士, 教授, 生物系主任

联系方式：生物化学与海洋生物材料实验室

邮箱：xgchen@ouc.edu.cn  电话：0532-82032586

地址：青岛市鱼山路5号, 266003，中国

工作照：

学习工作简历：

2003—现在：中国海洋大学 海洋生命学院 生物化学与生物材料研究室，教授，博士研究生导师，海洋生物系 系主任；

2000-2002:韩国大学(Korea University) 生命工学院 合作研究并攻读博士学位；1999.10-12:德国 格丁根大学 有机化学研究所 做政府间交流学者；

1998-1999:访问新加坡 MarinEx（私人）公司 任海洋药物合作研究专家；

1988-2000:中国海洋大学  海洋生命学院  助教-讲师- 副教授，并兼任生物工程系 副系主任、系主任；

1985-1988:东北师范大学 有机化学-生物化学专业 攻读硕士研究生。

青岛市技术拔尖人才，国家自然基金委项目评审专家组成员，山东省生物化学与海洋生物材料高校重点实验室主任、山东省中韩海洋生物材料国际合作研究中心主任，《海洋通讯》编委，青岛市甲壳质研究会副理事长。主持和完成国家科技部国际合作研究项目5项；国家‘863’项目1项；国家自然科学基金4项；韩国政府‘BK21’项目1项；教育部博士点基金2项;教育部留学回国基金1项；山东省攻关项目2项；山东省优秀科学家奖励基金1项；还参与完成各级政府项目10项，与企业合作开发或转让项目等20余项。作为首位人员获得教育部科技进步2等奖、国家海洋局科技成果2等奖、山东省高校自然科学1等奖、青岛市技术发明2等奖等共8项。获得技术发明专利16项，包括1项美国专利。已发表学术论文181篇，其中SCI论文120篇。

科研领域描述：

从事海洋生物材料研究和纳米生物技术研究。

1）皮肤组织修复生物材料研究，用壳聚糖和羧甲基壳聚糖等研制C-P-C结构的不对称生物膜，用于皮肤创伤组织再生修复研究，开展抑菌、药物缓释、促进创伤愈合和抑制瘢痕增生等生物功效和分子机制研究, 研发软组织创伤修复新型生物材料，该研究得到国家高新技术“863” 项目和国家自然科学基金项目等资助，取得了创新性研究成果，研究结果发表在Biomaterials等杂志。

2）纳米生物载体技术研究，用海洋生物大分子进行结构修饰，研究纳米载体的制备技术、靶向技术、载药技术、细胞和组织中输运过程，研究纳米材料与细胞和生物组织之间的相互作用，评价纳米尺度下载体的生物安全性和功效，创造新型纳米药物，该研究得到中、韩政府间国际合作重点研究项目的多次资助，与韩国大学H.J.Park教授课题组建立了长期合作的伙伴关系，取得多项突破性研究进展，研究结果发表在Nanomedicine，J. Controlled Release，Biomaterials:等杂志。

3）水凝胶类生物材料，用海洋生物大分子研制温度敏感型水凝胶和pH响应性水凝胶，研究水凝胶的性能、结构和生物相容性，开展细胞三维培养研究、药物缓释研究、生物支架研究、血管栓赛研究，研究生物材料微结构、微环境与组织细胞生长之间的生物学效应，研发微创型生物医用材料，该项目研究得到国家自然科学基金项目的多次资助，研究结果发表在等J.Mater.Sci.等杂志。

代表性成果：

一、学术论文:

1.  Ming Kong*, Hyunjin Park, Xiaojie Cheng, Xiguang Chen*. Spatial–temporal event adaptive characteristics of nanocarrier drugdelivery in cancer therapy. J.Controlled Release 172 (2013) 281–291.

2.  Kuikun Yang, Tingting Gao, Zixian Bao, Jing Su and Xiguang Chen*. Preparation and characterization of a novel thermosensitive nanoparticle for drug delivery in combined hyperthermia and chemotherapy. J. Mater. Chem. B, 2013, 1, 6442–6448.

3.  Ming Kong∗, Hyunjin Park, Chao Feng, Lin Hou, Xiaojie Cheng, Xiguang Chen∗. Construction of hyaluronic acid noisome as functional transdermal nanocarrier for tumor therapy. Carbohydrate Polymers 94 (2013) 634–641.

4.  Ya Liu, Ming Kong, Xiao Jie Cheng, Qian Qian Wang, Li Ming Jiang, Xi Guang Chen∗. Self-assembled nanoparticles based on amphiphilic chitosan derivative and hyaluronic acid for gene delivery. Carbohydrate Polymers 94 (2013) 309–316.

5.  Chao Feng, Zhiguo Wang, Changqing Jiang, Ming Kong, Xuan Zhou, Yang Li, Xiaojie Cheng∗, Xiguang Chen∗. Chitosan/o-carboxymethyl chitosan nanoparticles for efficient and safe oral anticancer drug delivery: In vitro and in vivo evaluation. Inter.J. Pharmaceutics 457 (2013) 158–167.

6.  Fang Kui Ma, Jing Li, Ming Kong, Ya Liu, Yi An∗, Xi Guang Chen∗. Preparation and hydrolytic erosion of differently structured PLGA nanoparticles with chitosan modification. International Journal of Biological Macromolecules 54 (2013) 174– 179.

7.  Qian Qian Wang, Ming Kong, Yi An, Ya Liu, Jing Jing Li, Xuan Zhou, Chao Feng, Jian Li, Shao Yan Jiang, Xiao Jie Cheng*, Xi Guang. Chen*. Hydroxybutyl chitosan thermo-sensitive hydrogel: a potential drug delivery system. J Mater Sci (2013) 48:5614–5623.  

8.  Kui Kun Yang, Ming Kong, Ya Nan Wei, Ya Liu, Xiao Jie Cheng, Jing Li, Hyun Jin Park, Xi Guang Chen*. Folate-modified–chitosan-coated liposomes for tumor-targeted drug delivery. J Mater Sci.2013, 48:1717–1728.

9.  Ya Nan Wei, Qian Qian Wang, Ting Ting Gao, Ming Kong, Kui Kun Yang, Yi An, Shao Yan Jiang, Jian Li, Xiao Jie Cheng*, Xi Guang Chen*. 3-D culture of human umbilical vein endothelial cells with reversible thermosensitive hydroxybutyl chitosan hydrogel. J Mater Sci: Mater Med, 2013 ,24(7):1781-1787.

10.Ya Liu, Hui Di Zang, Ming Kong, Fang Kui Ma, Qi Feng Dang, Xiao Jie Cheng, Qiu Xia Ji, Xi Guang Chen∗. In vitro evaluation of mucoadhesion and permeation enhancement of polymeric amphiphilic nanoparticles. Carbohydrate Polymers. 2012,89(2): 453-460.

11.Jing Li, Ming Kong, Xiao Jie Cheng, Qi Feng Dang, Xuan Zhou, Ya Nan Wei, Xi Guang Chen∗.Preparation of biocompatible chitosan grafted poly(lactic acid) nanoparticles. Inter. J. Biological Macromolecules. 2012,51(3): 221-227.      

12.Qi Feng Dang, Jing Quan Yan, Hong Lin, Xi Guang Chen∗, Cheng Sheng Liu∗, Qiu Xia Ji, Jing Jing Li. Design and evaluation of a highly porous thermosensitive hydrogel with low gelation temperature as a 3D culture system for Penaeus chinensis lymphoid cells. Carbohydrate Polymers. 2012,88(1): 361-368.

13.Ya Liu, Xiao Jie Cheng, Qi Feng Dang, Fang Kui Ma, Xi Guang Chen*, Hyun Jin Park, Bum Keun Kim∗.Preparation and evaluation of oleoyl-carboxymethy-chitosan (OCMCS) nanoparticles as oral protein carriers. J. Materials Science: Materials in Medicine. 2012,23(2): 375-384.

14.Qi Feng Dang, Shu Hua Zou, Xi Guang Chen*, Cheng Sheng Liu, Jing Jing Li, Xuan Zhou, Ya Liu and Xiao Jie Cheng. Characterizations of chitosan-based highly porous hydrogel—The effects of the solvent. J. Applied Polymer Science. Vol. 125, E88–E98 (2012).     

15. Qi Feng Dang, Jing Quan Yan, Jing Jing Li, Xiao Jie Cheng, Cheng Sheng Liu, Xi Guang Chen∗. Controlled gelation temperature, pore diameter and degradation of a highly porous chitosan-based hydrogel. Carbohydrate Polymers. 2011,83(1): 171-178.

16. Xiao Yan Li, Xi Guang Chen∗, Zhong Wu Sun, Hyun Jin Park, Dong-Su Cha. Preparation of alginate/chitosan/carboxymethyl chitosan complex microcapsules and application in Lactobacillus casei ATCC 393. Carbohydrate Polymers. 2011, 83(4): 1479-1485.

17.Jing Li, Ming Kong, Xiao Jie Cheng, Jing Jing Li, Wei Fang Liu, Xi Guang Chen∗.A facile method for preparing biodegradable chitosan derivatives with low grafting degree of poly(lactic acid). Inter. J. Biological Macromolecules. 2011,49(5): 1016-1021.

18.Hui Yun Zhou∗, Yan Ping Zhang, Wei Fen Zhang, Xi Guang Chen∗. Biocompatibility and characteristics of injectable chitosan-based thermosensitive hydrogel for drug delivery. Carbohydrate Polymers. 2011,83(4): 1643-1651.       

19.Jing Zhang, Xi Guang Chen∗, Gang Zheng Sun, Lu Huang, Xiao Jie Cheng. Effect of molecular weight on the oleoyl-chitosan nanoparticles as carriers for doxorubicin. Colloids and Surfaces B: Biointerfaces. 2010, 77: 125–130.

20.Qingsheng Zhao, Qiuxia Ji, Xiaojie Cheng, Gangzheng Sun, Chao Ran, Bing Zhao, Xiguang Chen*. Preparation of alginate coated chitosan hydrogel beads by thermosensitive internal gelation technique. J. Sol-Gel Science and Technology. 2010, 54:232-237.

21.Qi Feng Dang, Jing Quan Yan, Yan Li, Xiao Jie Cheng, Cheng Sheng Liu, Xi Guang Chen*. Chitosan Acetate as an Active Coating Material and Its  Effects on the Storing of Prunus avium L. J.Food Science.2010, 75(2): S125–S131.       

22.Ming Kong, Xi Guang Chen*, Ke Xing and Hyun Jin Park. Antimicrobial properties of chitosan and mode of action: A state of the art review. Inter.J.Food Microbiology. 2010, 144(1):51-63.   

23.Ke Xing, Xi Guang Chen∗, Ming Kong, Cheng Sheng Liu, Dong Su Cha, Hyun Jin Park. Effect of oleoyl-chitosan nanoparticles as a novel antibacterial dispersion system on viability, membrane permeability and cell morphology of Escherichia coli and Staphylococcus aureus. Carbohydrate Polymers. Vol.76, 2009, 17-22.  

24.Qing Sheng Zhao, Qiu Xia Ji, Ke Xing, Xiao Yan Li, Cheng Sheng Liu, Xiguang Chen∗. Preparation and characteristics of novel porous hydrogel films based on chitosan and glycerophosphate Carbohydrate Polymers. 76 (2009) 410–416.

25.Jing Zhang, Xi Guang Chen*, Cheng Sheng Liu, Hyun Jin Park. Investigation of polymeric amphiphilic nanoparticles as antitumor drug carriers. J Mater Sci: Mater Med. 20 (2009) 991–999.

26.LI Xiaoyan, CHEN Xiguang*. Drying of Micro-Encapsulated Lactic Acid Bacteria Effects of Trehalose and Immobilization on Cell Survival and Release Properties. J. Ocean Univ. China (Oceanic and Coastal Sea Research). Vol.8, 2009, 39-44.

27.Ke Xing,Xi Guang Chen*, Cheng Sheng Liu, Dong Su Cha, Hyun Jin Park. Oleoyl-chitosan nanoparticles inhibits Escherichia coli and Staphylococcus aureus by damaging the cell membrane and putative binding to extracellular or intracellular targets. International J. Food Microbiology. Vol.132, 2009,127–133.

28.Qing Sheng Zhao, Xiao Jie Cheng, Qiu Xia Ji, Chuan Zhen Kang, Xi Guang Chen*.Effect of organic and inorganic acids on chitosan/glycerophosphate thermosensitive hydrogel. J Sol-Gel Sci Technol. Vol.50, 2009, 111–118.

29.Qiu Xia Ji. Xi Guang Chen*. Qing Sheng Zhao. Cheng Sheng Liu. Xiao Jie Cheng. Ling Chong Wang. Injectable thermosensitive hydrogel based on chitosan and quaternized chitosan and the biomedical properties. J Mater Sci: Mater Med. Volume 20, 2009, 1603–1610.

30.Jiang W L, Chen X G*, Zhu H B, Hou J, Tian J W. Cornuside Attenuates Apoptosis and Ameliorates Mitochondrial Energy Metabolism in Rat Cortical Neurons. Pharmacology. 2009 Aug 21, 84(3):162-170.

31.Ling Chong Wang, Hao Wu, Xi Guang Chen*, Li De Li, Qiu Xia Ji, Cheng Sheng Liu, Le Jun Yu, Chao Ran, Qing Sheng Zhao. Biological evaluation of a novel chitosan-PVA-based local delivery system for treatment of periodontitis. J.Biomedical Materials Research Park A. 2009, vol.91A,1065-1076

32.Wei Fen Zhang, Xi Guang Chen*, Pi Wu Li, Qiang Zhi He, Hui Yun Zhou. Preparation and characterization of theophylline loaded chitosan/β- cyclodextrin microspheres. J Mater Sci: Mater Med. Vol.19, 2008, 305–310.

33.Hong Tao Pang, Xi Guang Chen*, Qiu Xia Ji, De Yu Zhong. Preparation and function of composite asymmetric chitosan/CM-chitosan membrane. J.materials science. Materials in medicine. Vol.19, 2008, 1413-1417.

34.Hui Yun Zhou, Xi Guang Chen*, Ming Kong, Cheng Sheng Liu, Dong Su Cha, John F. Kennedy. Effect of molecular weight and degree of chitosan deacetylation on the preparation and characteristics of chitosan thermosensitive hydrogel as a delivery system. Carbohydrate Polymers. Vol.73, 2008, 265–273.

35.Ling Chong Wang, Xi Guang Chen∗, Cheng Sheng Liu, Pi Wu Li, Ying Min Zhou. Dissociation Behaviors of Carboxyl and Amine Groups on Carboxymethyl-Chitosan in Aqueous System. Journal of Polymer Science, Part B: Polymer Physics. Vol. 46, 2008, 1419-1429.

36.Ling Chong Wang, Xi Guang Chen∗, Cheng Sheng Liu, Li De Li, Qiu Xia Ji, Le Jun Yu. Preparation of a Multistructural Film with CM-Chitosan and PVA, and In Vitro Ornidazole Release from the Carrier. J. Applied Polymer Science, Vol.110, 2008, 1136-1144.

37.LING CHONG WANG, XI GUANG CHEN∗, QUAN CHEN XU, CHENG SHENG LIU, LE JUN YU and YING MIN ZHOU. Plasma protein adsorption pattern and tissue-implant reaction of poly(vinyl alcohol)/ carboxymethyl-chitosan blend films. J. Biomater. Sci. Polymer Edn. Vol.19, 2008, 113–129.

38.Ming Kong, Xi Guang Chen∗, Cheng Sheng Liu, Chen Guang Liu, Xiang Hong Meng, Le Jun Yu. Antibacterial mechanism of chitosan microspheres in a solid dispersing system against E. coli. Colloids and Surfaces B: Biointerfaces. Vol.65, 2008, 197-202.

39.Ke Xing, Xiguang Chen*, Yanyan Li, Cheng Sheng Liu, Chen Guang Liu, Dong Su Cha, Hyun Jin Park. Antibacterial activity of oleoyl-chitosan nanoparticles: a novel antibacterial dispersion system. Carbohydrate Polymers. Vol.74, 2008, 117-120.

40.Xiao Yan Li, Xi Guang Chen*, Cheng Sheng Liu, Hong Ni Peng, Dong Su Cha. Effect of Trehalose and Drying Process on the Survival of Encapsulated Lactobacillus casei ATCC 393. Drying Technology. Vol. 26, 2008, 895-901.

41.Jing Zhang, Xi Guang Chen*, Wei Bing Peng, Cheng Sheng Liu. Uptake of oleoyl-chitosan nanoparticles by A549 cells. Nanomedicine: Nanotechnology, Biology, and Medicine. Vol.4, 2008, 208-214.

42.HONG NA PEI, XI GUANG CHEN*, YAN LI, HUI YUN ZHOU. Characterization and ornidazole release in vitro of a novel composite film prepared with chitosan/poly(vinyl alcohol)/alginate. J.Biomedical Materials Research. Part A. Vol.85,2008, 566-572. 

43.Yan Yan Li, Xi Guang Chen^*, Jing Zhang, Cheng Sheng Liu, Yu Ping Xue, Gang Zheng Sun, Wei Fen Zhang. In vitro release of rifampicin and biocompatibility of oleoylchitosan nanoparticles. J. Applied Polymer Science. Vol.111, 2008, 2269-2274.

44.Gang Zheng Sun, Xi Guang Chen*, Yan Yan Li, Cheng Sheng Liu, Chen Guang Liu, Bo Zheng, Zheng Hui Gong, Jian Jun Sun, Hen Chen, Jie Li, and Wen Xing Lin. Preparation and Properties of Amphiphilic Chitosan Derivative as a Coagulation Agent. Environmental Engineering Science. Vol.25, N.9, 2008. 1325-1332.

45.Qi Zhao Wang, Xi Guang Chen*, Zi Xiang Li, Song Wang, Cheng Sheng Liu, Xiang Hong Meng. Chen Guang Liu. Ying Hui Lv, Le Jun Yu. Preparation and blood coagulation evaluation of chitosan microspheres. J Mater Sci: Mater Med Vol.19,2008,1371-1377.

46.Wei Fen Zhang, Xi Guang Chen*, Pi Wu Li, Cheng Sheng Liu, Qiang Zhi He. Preparation and Characterization of Carboxymethyl Chitosan and β-Cyclodextrin Microspheres by Spray Drying. Drying Technology. Vol.26,2008,108–115.

47.Ai Hong Wang ; Xi Guang Chen *; Cheng Sheng Liu; Xiang Hong Meng ; Le Jun Yu ; Hua Wang. Preparation and characteristics of chitosan microspheres in different acetylation as drug carrier system. J.Microencapsulation. Vol.26,2008,593-602.

48.Yan Li, Xi Guang Chen,* Nan Liu, Cheng Sheng Liu, Chen Guang Liu, Xiang Hong Meng, Le Jun Yu, John F. Kenendy. Physicochemical characterization and antibacterial property of chitosan acetates. Carbohydrate Polymers. 2007,Vol.67: 227-232

49.Wei Fen Zhang, Xi Guang Chen,* Pi Wu Li, Qiang Zhi He, Hui Yun Zhou. Chitosan and chitosan/ β-cyclodextrin microspheres as sustained-release drug carriers. J.Applied Polymer Science. 2007，Vol.103：1183-1190

50.Jing Zhang, Xi Guang Chen, Yan Yan Li and Cheng Sheng Liu.  Self-assembled nanoparticles based on hydrophobically modified chitosan as carriers for doxorubicin. Nanomedicine: Nanotechnology, Biology and Medicine,2007,Vol.3,P 258-265

51.Ling-Chong Wang, Xi-Guang Chen,* De-Yu Zhong, Quan-Chen Xu. Study on poly(vinyl alcohol)/carboxymethyl-chitosan blend film as local drug delivery system. J Mater Sci: Mater Med, 2007, 18:1125–1133

52.Wang, Ye;Chen, Xi Guang;Lv, Ying Hui; Zhou, Hui Yun; Zhang, Jing. Effects of molecular structural parameters of carboxymethyl chitosan on the growth of fibroblasts in vitro . J. APPLIED POLYMER SCIENCE, 106 (5): 3136-3142 DEC 5 2007.

53.Hui Yun Zhou, Xi Guang Chen,* Wei Fen Zhang. In vitro and in vivo evaluation of mucoadhensiveness of chitosan/cellulose acetate multimicrospheres. J.Biomedical Materials Research Part A. 2007, vol83A: 1146-1153

54.Ling-Chong Wang, Xi-Guang Chen, Le-Jun Yu, Pi-Wu Li, Controlled Drug Release Through     Carboxymethylchitosan/Poly(vinyl alcohol) Blend Films. POLYMER ENGINEERING AND SCIENCE.  2007, Vol. 47, 1373-1379.

55.YAN YAN LI, XI GUANG CHEN,* CHENG SHENG LIU, DONG SU CHA,HYUN JIN PARK, AND CHONG M. LEE. Effect of the Molecular Mass and Degree of Substitution of Oleoylchitosan on the Structure, Rheological Properties, and Formation of Nanoparticles. J. Agric. Food Chem. 2007, 55, 4842 – 4847

56.X.G.Chen*,C.S.Liu,C.G.Liu,X.H.Meng,C.M.Lee,H.J.Park. Preparation and bio- compatibility of chitosan microcarriers as biomaterial. Biochemical Engineering J. 2006, Vol 27: 269–274

57.N.Liu, X.G. Chen*, H.J.Park,C.G.Liu,C.S.Liu,X.H.Meng,L.J.Yu. Effect of MW and concentration of chitosan on antibacterial activity of Escherichia coli. Carbohydrate Polymers 2006, Vol.64: 60–65.

58.H.Y.Zhou,X.G.Chen*,C.S.Liu,X.H.Meng,C.G.Liu,J.He,L.J.Yu. Cellulose acetate/chitosan multimicrospheres preparation and ranitidine hydrochloride release in vitro. Drug Delivery, 2006, Vol.13:261–267.

59.Hui Yun Zhou, Xi Guang Chen*, Cheng Sheng Liu, Xiang Hong Meng, Chen Guang Liu, Le Jun Yu. Release characteristics of three model drugs from chitosan/cellulose acetate multimicrospheres. Biochemical Engineering J.2006, Vol.31: 228-233.

60.Q.Z.Wang,X.G.Chen*,N.Liu,S.X.Wang,C.S.Liu,X.H.Meng,C.G.Liu. Protonation constants of chitosan with different molecular weight and degree of deacetylation. Carbohydrate Polymers 2006, Vol.65: 194–201.

61.Y.Y.Li,X.G.Chen*,L.M.Yu,S.X.Wang,G.Z.Sun,H.Y.Zhou.Aggregation of Hydrophobically Modified Chitosan in Solution and at the Air–Water Interface. J.Applied Polymer Science, 2006,Vol.102, 1968–1973.

62.H.Y.Zhou,X.G.Chen,C.S.Liu,X.H.Meng,L.J.Yu,X.Y.Liu,N.Liu. Chitosan/cellulose acetate microspheres preparation and ranitidine release in vitro. Pharmaceutical Development and Technology. 2005 ,Vol.10,No.2:219-225. 

63.刘  楠，陈西广，刘成圣，孟祥红，于乐军，周惠云. 壳多糖抑菌性能研究进展. 海洋科学，2005,129(10):90-92.

64.倪思亮，陈西广，钟德玉，霍  光，刘成圣，孟详红，刘晨光，贺  君，于乐军，王令充. 壳聚糖与羧甲基壳聚糖复合不对称膜生物相容性. 高技术通讯,2005, 15 (8):61-66. 

65.X.G. Chen, H.J. Park. Chemical characteristics of O-carboxymethyl chitosans related to the preparation conditions. Carbohydrate Polymer. 2003,Vol.53,No.4:355-359

66.X.G. Chen, Chang M. Lee, H.J. Park, O/W emulsification for the self-aggregation and nanoparticle formation of linoleic acid - modified chitosan in the aqueous system. J. Agric. Food Chem. 2003，vol.51, No.10: 3135-3139

67.郑立 陈西广 刘万顺 韩笑天 严小军,羧甲基壳聚糖膜对皮肤成纤维细胞相容性研究,生物化学与生物物理学学报, 2003,V.30,No.2: 314-319

68.X.G. Chen, Z. Wang, W.S. Liu, H.J. Park, The effect of carboxymethyl -chitosan on proliferation and collagen secretion of normal and keloid skin fibroblasts. Biomaterials. 2002,No.23: 4609-4614.

69.X.G. Chen, L. Zhen, Z. Wang, C.R. Lee, H.J. Park. Molecular Affinity and permeability of Different Molecular Weight Chitosan Membranes. J. Agric. Food Chem. 2002,Vol.50 No. 21: 5915-5918

70.陈西广，郑立，刘万顺, 刘成圣，刘晨光. 几丁质聚糖膜通透性的研究. 中国海洋药物，2001,81(3):12-16

71.郑立，陈西广，刘晨光，刘万顺，刘成圣. 几丁聚糖降解技术的研究进展. 海洋科学，2000,24(10):18-20

二、发明专利

1） 一种壳聚糖醋酸盐的制备方法，专利号: ZL 201110257843.6 

2） 一种壳聚糖羟丁基衍生物的制备方法，专利号：ZL201110214776.x.

3） Process for preparing compounds of chitosan saccharified with aminosugar，Paten Number:US 8201971B2.

4） 胺糖化几丁聚糖复合物的制备方法，专利号：ZL200810238392.X.

5） 一种羧甲基氨基多糖冬枣保鲜成膜剂的制造方法,专利号: ZL 03139238.5 

6） 一种几丁聚糖脂复合物的制造方法,专利号：ZL200310114676.5

7） 大祘素微胶囊及其制备方法 ,专利号：ZL200410036331.7

8） 一种卡托普利复合几丁聚糖缓释微球的制备方法，专利号：ZL2004100355433.7

9） 一种制备甲壳质微球载体的方法，专利号：ZL96115714.3

三、获得奖励

1） 国家海洋局 海洋创新成果奖 二等奖(201022701B)，海洋生物材料壳聚糖纳米技术研究。主要完成人：陈西广、程晓杰、刘成圣、吉秋霞、刘晨光、孟祥红、于乐军。

2）国家教育部 自然科学 二等奖(2010-091),壳聚糖自组装纳米载体构建及生物功能研究，主要完成人：陈西广,程晓杰,刘成圣,刘晨光,孟祥红,于乐军。

3）国家教育部，科技进步 二等奖（2004-203），海洋壳多糖生物材料研究与开发，主要完成人：陈西广 刘成圣 刘晨光 孟祥红贺君于乐君 郎刚华。

4）山东高等学校优秀科研成果奖,一等奖(2010BZ10088)，壳聚糖纳米生物材料及功能研究，主要完成人：陈西广、程晓杰，刘成圣、刘晨光、孟祥红。 

5）山东省教育厅，高等学校优秀科研成果将，自然科学 二等奖（2004320260），海洋壳多糖生物材料研究与开发，主要完成人：陈西广 刘成圣 刘晨光 孟祥红 郎刚华。

6）青岛市科委，技术发明 2等奖(F2005-2-2-1)，新型几丁聚糖微、纳米胶囊载体与微膜材料，主要完成人：陈西广 刘成圣 刘晨光 孟祥红 贺君。