姓名：焉翠蔚
学历/职称/职务：教授
联系方式：
邮箱：cuiweiyan@ouc.edu.cn 电话：13687698188
地址：山东省青岛市鱼山路5号中国海洋大学 海洋生命学院
学习工作简历：
1983年7月 曲阜师范大学生物系获学士学位
1988年7月 山东农业大学获硕士学位
1983年7月-1992年9月 曲阜师范大学生物系助教
1992年10月-1996年11 曲阜师范大学生物系讲师
1996年12月-2000年11月 曲阜师范大学生物系副教授
2000年12月-2002年6月 曲阜师范大学生物系教授
2002年7月-----至今 中国海洋大学海洋生命学院教授（硕士生导师）
科研领域描述：主要从事生物化学教学科研工作，研究方向为生物化学与海洋生物活性物质，金属配合物的合成及生物活性研究
代表性成果：
承担和参与的课题：
1．“靶向拓扑异构酶I抗癌双核配合物的设计、合成及构效关系研究” ，国家自然基金(30672515)
2．“桥联多核配合物构筑的人工核酸酶催化水解动力学研究” ，国家自然基金（20471056) 。
3．”新型抗癌双核钒配合物的设计、合成及构效关系研究”，国家自然科学基金（21071133）。
4．“以拓扑异构酶I为靶点的双核钒配合物的合成及抗癌活性研究”，教育部博士点专项基金（20060423005) 。
5．“新型绿色饲料添加剂COSL的研制”，青岛市攻关（04-2-NN-25) 。
6．“靶向拓扑异构酶I抗癌化合物的合成研究”，青岛市攻关(06-2-2-11-jch)。
7．“海洋多糖稀士配合物的研制”，山东省科技攻关（031070115）。
8．“海洋水产品废弃物中牛磺酸和蛋白质资源的开发及其高值化利用关键技术研究”，青岛市科技发展计划（12-1-3-52-(1)-nsh）。
9．“多级膜分离与分子印迹耦合技术在海洋水产品废弃物高值化利用中的研究与开发”，山东省科技攻关（2011GHY11521）。
10．“海藻中酪氨酸酶抑制剂的筛选及抑制机理研究”，国家海洋局开放实验室基金（MBSMAT-2012-05）。
11．“海洋壳寡糖单体规模化制备关键技术研究”，山东省科技攻关（2012GHY11525）。
12．“海藻提取物抑制黄嘌呤氧化酶的机理及抗高尿酸血症”，青岛市科技发展计划（11-2-4-1-(9)-jch）
13.“新型拓扑异构酶I抑制剂的设计、合成及抗癌活性研究”，青岛市科技发展计划（09-1-3-73-jch）
代表性论文：
1. Yan C.-W., Li L.-J., Li Y.-T., Zhang G.-L., Sun W., Synthesis and magnetism of Cu(II)-Ln(III)-Cu(II)(Ln = La, Nd, Tb, Ho, Er) trinuclear complexes bridged by N,N’-bis[3-(dimethylamino)propyl]oxamido. Polish J. Chem., 2005, 79(9), 1425-1434.
2. Yan C.-W., Li Y.-T., Zhu C.-Y., Synthesis, characterization and magnetic properties of copper(II)- iron(III)heterotetranuclear complexes bridged by tris(oxalato)ferrate(III). Polish J. Chem. 2004, 78(5), 653-661.
3. Yan C.-W., Li Y.-T., Zhu-C.-Y., Guan H.-S., Synthesis and magnetic studies of m-oxamido- bridged Cu(II)-Cr(III) and Cu(II)-Fe(III) heterobinuclear complexes. Synth. React. Inorg. Met.-Org. Chem., 2004, 5(34), 929-941.
4. Yan C.-W., Li Y.-T., Lou J.-F., Zhu C.-Y., Synthesis, characterization and magnetic properties of tetracarboxylato-bridged binuclear iron(II) complexes. Synth. React. Inorg. Met.-Org. Chem., 2004, 5(34), 979-991.
5. Yan-C.-W., Li-Y.-T., Zhu-C.-Y., Synthesis, characterization and magnetism of Mu-2-chloroterephthalato-bridged binuclear lanthanide(III) complexes. Synthesis and reactivity in inorganic and metal-organic chemistry. 2004, Vol 34, Iss 5, pp 953-966.
6. Xu X.-W, Li X.-J., Zhan S.-H., Li Y.-T. , Wu Z.-Y. Yan C.-W.*, Synthesis and structure of a new tetracopper(II) complex bridged both by oxamido and phenolato groups: Cytotoxic activity, and reactivity towards DNA and BSA. J. Mol. Struct., 1039(2013), 28–36.
7．Li X.-J., Zheng K., Wang L.-D., Yan-Tuan Li, Zhi-Yong Wu, Cui-Wei Yan*, Syntheses and crystal structures of tetracopper(II) complexes bridged by asymmetric N,N′-bis(substituted)oxamides: molecular docking, DNA-binding and in vitro anticancer activity. J. Inorg. Biochem., 128(2013), 97–107.
8. Xiao-Wen Li, Xue-Jie Li, Yan-Tuan Li, Zhi-Yong Wu, Cui-Wei Yan*, Syntheses and structures of new trimetallic complexes bridged by N-(5-chloro-2-hydroxyphenyl)-N′- [3-(dimethylamino) propyl]oxamide: cytotoxic activities, and reactivities towards DNA and protein.. J. Photochem. Photobiol. B Biol. 118(2013), 22–32.
9. Xi-Ling Wang, Man Jiang, Yan-Tuan Li, Zhi-Yong Wu, Cui-Wei Yan*. Synthesis and crystal structure of a new dicopper (II) complex with N-benzoato-N′-(hydroxypropyl) oxamide as ligand: cytotoxic activities and reactivities towards DNA and BSA.. J. Coord. Chem., 66(2013), 1985–2003.
10. Ting-Ting Xing, Shu-Hui Zhan, Yan-Tuan Li, Zhi-Yong Wu, Cui-Wei Yan*, Synthesis and structure of a new tetracopper(II) complex with N-benzoate-N′-[2-(2-hydroxyethylamino) ethyl] oxamide as bridging ligand: in vitro anticancer activities and DNA-and BSA-binding studies.J. Coord. Chem., 66(2013), 3149–3169.
11. Yang Gao, Yan-Tuan Li, Zhi-Yong Wu, Cui-Wei Yan*, Synthesis and crystal structure of binuclear copper(II) complex bridged by N-(2-Hydroxyphenyl)-N′-[3-(diethylamino)propyl] oxamide: in vitro anticancer activity and reactivity toward DNA and protein.J. Biochem. Mol. Toxic., 27(2013), 412–424.
12. Ling-Dong Wang, Kang Zheng, Yan-Tuan Li, Zhi-Yong Wu, Cui-Wei Yan*, Synthesis and crystal structure of a new copper(II) complex with N,N′-(4,4′-bithiazole-2,2′-diyl) diacetimidamide as ligand: molecular docking, DNA-binding and cytotoxicity activity studies. J. Mol. Struct., 1037(2013), 15–22.
13. Kang Zheng, Man Jiang, Yan-Tuan Li, Zhi-Yong Wu, Cui-Wei Yan*, Synthesis and crystal structure of a ternary copper(II) complex of 2,2′-bipyridine and picrate: Molecular docking, reactivity towards DNA and in vitro anticancer activity.J. Mol. Struct., 1058(2014), 97–105.
14. Xiao-Wen Li, Lin Tao, Yan-Tuan Li, Zhi-Yong Wu, Cui-Wei Yan*, Bimetallic complexes constructed from asymmetrical N,N’-bis(substituted)oxamide: Cytotoxicities, and reactivities towards DNA and protein. European Journal of Medicinal chemistry. 2012, 54, 697-708
15. Yong-Jun Zheng, Xiao-Wen Li, Yan-Tuan Li, Zhi-Yong Wu, Cui-Wei Yan*, Synthesis and structure of new tetracopper(II) complexes bridged by 2-{N’-[2-(dimethylamino)- ethyl]oxamido} benzoate: DNA-binding and anticancer activity. Journal of photochemistry and photobiology, 2012, 114, 27–37.
16. Xin Li, Xue-Jie Li, Yan-Tuan Li, Zhi-Yong Wu, Cui-Wei Yan*, Syntheses and structures of tetracopper(II) complexes with an N-benzoate-N’-[3-(2-hydroxylethylammino)- propyl]oxamide ligand: reactivity towards DNA, cytotoxic and antimicrobial activities. New J. Chem., 2012, 36, 2472–2483
17. Fang-Hong He, Lin Tao, Xiao-Wen Li, Yan-Tuan Li, Zhi-Yong Wu, Cui-Wei Yan*, Syntheses and structures of new dicopper(II) complexes bridged by N-(2-hydroxyphenyl)- N’-(3-aminopropyl)oxamide: DNA-binding properties and cytotoxic activities. New J. Chem., 2012, 36, 2078–2087
18. Xiao-Wen Li, Xin Li, Yan-Tuan Li, Zhi-Yong Wu, Cui-Wei Yan*, Synthesis and structures of binuclear copper(II) complexes bridged by N-(5-chloro-2-hydroxyphenyl)-N’-[3- (dimethylamino)propyl]oxalamide ligand: DNA-binding properties and cytotoxic activities.Journal of . Organometallic Chemstry., 2012, 700, 48-57
19. Xin Li, Yan-Tuan Li, Zhi-Yong Wu, Yong-Jun Zheng, Cui-Wei Yan*, Synthesis, structure, DNA- binding properties and cytotoxic activities of a new one-dimensional polymeric copper(II) complex with N-benzoate-N’-[3-(2-hydroxyl-ethylammino)propyl]oxamide as ligand. Inorganica Chimica Acta, 2012, 385, 150–157
20. Xiao Wang, Yan-Tuan Li*, Zhi-Yong Wu, Xiao-Wen Li, Cui-Wei Yan*, Synthesis, structures, anticancer activities and DNA-binding properties of new dicopper(II) complexes bridged by N-benzoato-N’-(2-amino-2-methylethyl)oxamide. Struct. Chem., 2012, 23, 1509–1522
21 Xiao-Wen Li, Yan-Tuan Li, Zhi-Yong Wu, Cui-Wei Yan*, Syntheses and structures of bicopper(II) complexes bridged by N-(5-chloro-2-hydroxyphenyl)-N’-[3-(dimethylamino)- propyl]oxamide: Cytotoxic activities, and reactivities towards DNA and protein. Inorg. Chim. Acta, 2012, 390, 190–198.
22 Yong-Jun Zheng, Xiao-Wen Li, Yan-Tuan Li, Zhi-Yong Wu, Cui-Wei Yan*, Synthesis, structure, anticancer activities, and DNA-binding properties of a 1-D polymeric copper(II) complex alternately bridged by oxamide and terephthalate. Journal of Coordination Chemistry, 2012, 65, 3530–3545.
23. Lin-Lin Zhang, Ling-Dong Wang, Yan-Tuan Li, Zhi-Yong Wu, Cui-Wei Yan*, Synthesis and structure of 1D copper(II) polymers with dissymmetrical N,N’-bis(substituted)- oxamide ligands: Cytotoxicity and DNA-binding property. J. Inorg. Organomet. Polym., 2012, 22, 1128–1138.
24. Fang-Hong He, Man Jiang, Yan-Tuan Li, Zhi-Yong Wu, Cui-Wei Yan*, Synthesis, structure, cytotoxic activities and DNA-binding properties of a 1D copper(II) complex bridged both by oxamidate and terephthalato groups. J. Inorg. Organomet. Polym., 2012, 22, 756–765.
25. Wen-Cai Chen, Ling-Dong Wang, Yan-Tuan Li , Zhi-Yong Wu, Cui-Wei Yan* , Synthesis, crystal structure, cytotoxicities and DNA-binding properties of a tetracopper(II) complex with N-benzoato-N’-[2-(2-hydroxyethylamino) ethylamino]oxamide ligand. Trans. Met. Chem., 2012, 37, 569–577
26. Rui-Hao Yu, Yong-Jun Zheng, Yan-Tuan Li , Zhi-Yong Wu, Cui-Wei Yan*, Syntheses and structures of copper(II) and nickel(II) complexes with N,N’-(4,4’-bithiazole- 2,2’-diyl)diacetimidamide ligands: in vitro cytotoxicities and DNA-binding properties. Trans. Met. Chem., 2012, 37, 399–406
27．焉翠蔚，随建强，王镇，赵庆娅，黎玲屹，菲律宾蛤仔碱性磷酸酶的分离纯化及部分性质研究。中国海洋大学学报，2012，42（7-8）：033~037。
28. 焉翠蔚，肖宜华，朱岩松，徐睿，多效唑对２种海洋微藻生长和抗氧化酶活性的影响．中国海洋大学学报，2008, 38(2): 291~296.
29. 焉翠蔚，赵庆娅，张珞等，海带提取物对黄嘌呤氧化酶的抑制作用，中国海洋大学学报，2013，43（12）：36-40。
30，焉翠蔚，徐睿，孙岩等，菲律宾蛤提取物抑制酪氨酸酶活性的研究。中国海洋大学学报，2009，39（6）：1233~1236。
荣誉称号：山东省第六届青年科技奖
