姓名：刘雅
职称：教授/博导
邮箱：yaliu @ouc.edu.cn
地址：山东省青岛市鱼山路5号中国海洋大学科学馆210
科研领域：生物医用材料的研发与组装调控，主要包括：生物合成、纳米技术、药物递送、肿瘤治疗、组织工程、过度免疫治疗等。
学习工作简历：
2022年12月-2023年12月：新加坡国立大学 访问学者
2012年8月—2014年1月：国家纳米科学中心 联合培养
2008年9月—2013年6月：中国海洋大学 海洋生命学院 海洋生物学专业 博士
科研项目与奖励：
主持国家自然科学基金、山东省自然科学基金、青岛海洋科技中心前沿技术自由探索项目、中国博士后基金特别资助、中国博士后科学面上基金、青岛市自主创新应用专项、青年教师专项基金等；获得山东省优秀学位论文指导教师、山东省自然科学学术创新奖、山东省优秀博士学位论文、山东省研究生优秀科技创新成果奖、中国海洋大学第十四届优秀博士学位论文一等奖等多项学术奖励。
代表性成果
一、发表论文：
1. Tingjie Zhang#, Jianke Yang#, Guofeng Cheng, Fanhu Meng, Yupeng Li, Jingqiao Wang, Longfei Li, Shuangyu Bi, Xiguang Chen, Ya Liu*. Reassembly nanomaterials-mediated engineered bacteria lysis for reshaping immunosuppressive microenvironment. Biomaterials 2026, 332, 124148
2. Jiajia Li#, Chen Du#, Xiaoping Yang, Yingxia Yao, Di Qin, Fanhu Meng, Shuangshuang Yang,Yi Tan, Xiguang Chen, Wenqing Jiang*, Ya Liu*. Instantaneous self-healing chitosan hydrogels with enhanced drug leakage resistance for infected stretchable wounds healing. Small 2025, 202409641.
3. Jingqiao Wang, Lingyang Meng, Fanhu Meng, Tingjie Zhang, Guofeng Cheng, Xiguang Chen, Ya Liu*. Natural Killer Cell-Mimicking Hypoxia-Responsive Nanomedicines for Tumor-Specific Suppression and Immune Regulation. Small 2025, 21, e05680.
4. Jiahao Zhuang#, Ya Liu#, Dandan Wang, Ruian Li, Dongfeng Zhang,* Bin Liu*. A Dual-Functional Prodrug for Imaging and Eradication of Drug-Resistant Gram-Negative Bacteria. ACS Nano 2025, 19, 31507−31515.
5. Zhen-Wei Deng#, Jian-Ke Yang#, Kai-Jin Qiu#, Ting-Jie Zhang, Zheng He, Na Wang, Xi-Guang Chen, Ya Liu*. Long-term combined blockade of CXCR4 and PD-L1 with in vivo reassembly for intensive tumor interference. Journal of Controlled Release 370 (2024) 453–467.
6. Zhuang Teng#, Jianke Yang#, Xiguang Chen, Ya Liu*. Intranasal Morphology Transformation Nanomedicines for Long-Term Intervention of Allergic Rhinitis. ACS Nano 17(2023) 25322−25334.
7. Ying-Hua Guan, Na Wang, Zhen-Wei Deng, Xi-Guang Chen, Ya Liu*. Exploiting autophagy-regulative nanomaterials for activation of dendritic cells enables reinforced cancer immunotherapy. Biomaterials 282 (2022) 121434.
8. Cong-Shan Yuan#, Zhuang Teng#, Shuang Yang#, Zheng He, Ling-Yang Meng, Xi-Guang Chen, Ya Liu*. Reshaping hypoxia and silencing CD73 via biomimetic gelatin nanotherapeutics to boost immunotherapy. Journal of Controlled Release 351 (2022) 255-271.
9. Mengjie Sun#, Di Qin#, Pengsheng Fan, Xiguang Chen, Ya Liu*. Chitosan-centered nanosystems as sustained therapeutics for allergic rhinitis intervention: Inhibition of histamine-induced cascades.Journal of Controlled Release335 (2021) 422-436.
10. Mei-Ping Tian, An-Di Zhang, Ying-Xia Yao, Xi-Guang Chen, Ya Liu*. Mussel-inspired adhesive and polypeptide-based antibacterial thermo-sensitive hydroxybutyl chitosan hydrogel as BMSCs 3D culture matrix for wound healing. Carbohydrate Polymers 261 (2021) 117878.
11. Ya Liu, Di Zhang, Zeng-Ying Qiao, Guo-Bin Qi, Xing-Jie Liang, Xi-Guang Chen*, Hao Wang*. A Peptide-Network Weaved Nanoplatform with Tumor Microenvironment Responsiveness and Deep Tissue Penetration Capability for Cancer Therapy. Advanced Materials 27 (2015) 5034–5042.
12. Ya Liu, Li-Li Li, Guo-Bin Qi, Yun-Shan Fan, Xi-Guang Chen*, Hao Wang*. Dynamic Disordering of Co-Assemblied Liposomal Cocktails: Spatio-Temporal Controlled Release of Cargoes to Circumvent Drug Resistance. Biomaterials 35 (2014) 3406-3415.
二、专利
1.刘雅，李瑞安. 一种具有免疫调节及抗炎功能的鼻用温敏水凝胶及其制备方法与应用. 国家发明专利，申请号：2025112501343
2. 刘雅，杨赵，刘光磊，桂桢彤，王静巧. 一种基于酵母发酵全组分的乳液及其制备方法. 国家发明专利，申请号：2026103890671
3. 刘雅，王静巧,刘光磊. 羟丁基壳聚糖-糖脂复合可喷涂水凝胶及其制备方法. 国家发明专利，申请号：2026109578217
4. 陈西广，秦迪，程晓杰，孔明，刘雅，冯超. 一种鱼鳞基质骨修复材料的制备方法及应用.国家发明专利，ZL202211209835.9
