师资队伍

杨立昆

发布者：张文博发布时间：2023-10-17浏览次数：538

杨立昆，博士，讲师，硕士生导师

邮箱：yanglikun@ouc.edu.cn

电话：0532-85906579


承担课程：

代谢生物化学


学习工作经历：

2009~2013，中国海洋大学海洋生命学院，学士，生物科学专业

2013~2015，中国海洋大学海洋生命学院，硕士研究生, 海洋生物学专业

2015~2019，美国奥本大学，博士，生物医学专业

2019~2021，美国埃默里大学，博士后

2021至今，中国海洋大学海洋生命学院，讲师


主要科研领域：

主要从事海洋无脊椎动物发育过程调控机制及环境适应分子基础研究。近年来研究成果在国际主流刊物发表SCI论文10余篇。主持承担了国家自然科学基金青年项目、国家重点研发计划项目（子任务）、山东省自然科学基金青年项目、中国博士后基金面上项目等。


代表性成果：（#共同第一；*通讯作者）

  1. Yang, L. K., Zhang, J., Liu, D., Han, T. Y., Qin, Q. S., Wang, A. Q., Dong, B.*. (2023). Ancestral glycoprotein hormone and its cognate receptor present in primitive chordate ascidian: Molecular identification and functional characterization. International Journal of Biological Macromolecules. 229: 401-412.

  2. Wang, Z., Ouyang, X., Tan, Z., Yang, L. K.*, Dong, B. (2023). Quantitative phosphoproteomics reveals the requirement of DYRK1-mediated phosphorylation of ion transport- and cell junction-related proteins for notochord lumenogenesis in ascidian. Cells. 12: 921.

  3. Zhang, J., Dong, B. *, & Yang, L. K.* (2022). Molecular Characterization and Expression Analysis of Putative Class C (Glutamate Family) G Protein-Coupled Receptors in Ascidian Styela clava. Biology, 11(5): 782.

  4. Yang, L. K.#, Hou, Z. S.#, & Tao, Y. X.* (2021). Biased signaling in naturally occurring mutations of G protein-coupled receptors associated with diverse human diseases. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1867(1):165973.

  5. Yang, L. K. & Tao, Y. X.* (2020). Alanine scanning mutagenesis of the DRYxxI motif and intracellular loop 2 of human melanocortin-4 receptor. International Journal of Molecular Sciences, 21(20):7611.

  6. Yang, L. K., Zhang, Z. R., Wen, H. S., & Tao, Y. X.* (2019). Characterization of channel catfish (Ictalurus punctatus) melanocortin-3 receptor reveals a potential network in regulation of energy homeostasis. General and Comparative Endocrinology, 277:90-103.

  7. Yang, L. K. & Tao, Y. X.* (2019). Physiology and pathophysiology of the 3-adrenerigic receptor. Progress in Molecular Biology and Translational Science, 161:91-112.

  8. Yi, T. L.#, Yang, L. K.#, Ruan, G. L., Yang, D. Q., & Tao, Y. X.* (2018). Melanocortin-4 receptor in swamp eel (Monopterus albus): Cloning, tissue distribution, and pharmacology. Gene, 678:79-89.

  9. Yang, L. K. & Tao, Y. X.* (2017). Biased signaling at neural melanocortin receptors in regulation of energy homeostasis. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1863:2486-2495.

  10. Pan, C., Kang, J., Hwang, J.S., Li, J., Boese, A.C., Wang, X., Yang, L., Boggon, T.J., Chen, G.Z., Saba, N.F., Shin, D.M., Magliocca, K.R., Jin, L., Kang, S.* (2021). Cisplatin-mediated activation of glucocorticoid receptor induces platinum resistance via MAST1. Nature communications, 12(1):1-15.